A new in vivo analysis model to detect sexually dimorphic rat liver cytochrome P450 gene expression dependent on growth hormone secretory patterns

Several drug-metabolizing cytochrome P450 (CYP) enzymes exhibit sexual dimorphism depending on the pituitary growth hormone (GH) secretory patterns. However, the mechanism underlying CYP sexual dimorphism remains unclear. We previously established a transgenic (Alb-DsRed2 Tg) rat that expressed red...

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Veröffentlicht in:	Experimental Animals 2016, Vol.65(4), pp.447-454
Hauptverfasser:	Maruyama, Motoyo, Fujisawa, Masahiko, Yokosuka, Makoto, Saito, Toru R., Hayama, Shin-ichi, Akimoto, Toshio, Hakamata, Yoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism cytochrome P450 Cytochrome P450 Family 2 - genetics Cytochrome P450 Family 2 - metabolism Female Gene Expression Growth Hormone - metabolism in vivo imaging Liver - metabolism Luminescent Proteins - chemistry Male Models, Animal Original Rats Rats, Transgenic Rats, Wistar Red Fluorescent Protein RNA, Messenger - metabolism Sex Characteristics sexual dimorphism Steroid 16-alpha-Hydroxylase - genetics Steroid 16-alpha-Hydroxylase - metabolism Steroid Hydroxylases - genetics Steroid Hydroxylases - metabolism transgenic rat
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