A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules
Cholera is a devastating diarrhoeal disease caused by certain strains of serogroup O1/O139 Vibrio cholerae . Mobile genetic elements such as genomic islands (GIs) have been pivotal in the evolution of O1/O139 V. cholerae . Perhaps the most important GI involved in cholera disease is the V. cholerae...
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| Veröffentlicht in: | Scientific reports 2016-11, Vol.6 (1), p.36891-36891, Article 36891 |
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| creator | Labbate, Maurizio Orata, Fabini D. Petty, Nicola K. Jayatilleke, Nathasha D. King, William L. Kirchberger, Paul C. Allen, Chris Mann, Gulay Mutreja, Ankur Thomson, Nicholas R. Boucher, Yan Charles, Ian G. |
| description | Cholera is a devastating diarrhoeal disease caused by certain strains of serogroup O1/O139
Vibrio cholerae
. Mobile genetic elements such as genomic islands (GIs) have been pivotal in the evolution of O1/O139
V. cholerae
. Perhaps the most important GI involved in cholera disease is the
V. cholerae
pathogenicity island 1 (VPI-1). This GI contains the toxin-coregulated pilus (TCP) gene cluster that is necessary for colonization of the human intestine as well as being the receptor for infection by the cholera-toxin bearing CTX phage. In this study, we report a GI (designated GI
Vch
S12) from a non-O1/O139 strain of
V. cholerae
that is present in the same chromosomal location as VPI-1, contains an integrase gene with 94% nucleotide and 100% protein identity to the VPI-1 integrase, and attachment (
att
) sites 100% identical to those found in VPI-1. However, instead of TCP and the other accessory genes present in VPI-1, GI
Vch
S12 contains a CRISPR-Cas element and a type VI secretion system (T6SS). GIs similar to GI
Vch
S12 were identified in other
V. cholerae
genomes, also containing CRISPR-Cas elements and/or T6SS’s. This study highlights the diversity of GIs circulating in natural
V. cholerae
populations and identifies GIs with VPI-1 recombination characteristics as a propagator of CRISPR-Cas and T6SS modules. |
| doi_str_mv | 10.1038/srep36891 |
| format | Article |
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Vibrio cholerae
. Mobile genetic elements such as genomic islands (GIs) have been pivotal in the evolution of O1/O139
V. cholerae
. Perhaps the most important GI involved in cholera disease is the
V. cholerae
pathogenicity island 1 (VPI-1). This GI contains the toxin-coregulated pilus (TCP) gene cluster that is necessary for colonization of the human intestine as well as being the receptor for infection by the cholera-toxin bearing CTX phage. In this study, we report a GI (designated GI
Vch
S12) from a non-O1/O139 strain of
V. cholerae
that is present in the same chromosomal location as VPI-1, contains an integrase gene with 94% nucleotide and 100% protein identity to the VPI-1 integrase, and attachment (
att
) sites 100% identical to those found in VPI-1. However, instead of TCP and the other accessory genes present in VPI-1, GI
Vch
S12 contains a CRISPR-Cas element and a type VI secretion system (T6SS). GIs similar to GI
Vch
S12 were identified in other
V. cholerae
genomes, also containing CRISPR-Cas elements and/or T6SS’s. This study highlights the diversity of GIs circulating in natural
V. cholerae
populations and identifies GIs with VPI-1 recombination characteristics as a propagator of CRISPR-Cas and T6SS modules.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep36891</identifier><identifier>PMID: 27845364</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/23 ; 45/29 ; 45/77 ; 631/326/171/1878 ; 631/326/421 ; Bacterial Proteins - genetics ; Cholera ; Clustered Regularly Interspaced Short Palindromic Repeats ; Colonization ; CRISPR ; Genomes ; Genomic Islands ; Humanities and Social Sciences ; Integrase ; Intestine ; multidisciplinary ; Multigene Family ; Pathogenicity ; Pathogens ; Phages ; Recombination ; Science ; Secretion ; Sequence Analysis, DNA ; Toxins ; Type VI Secretion Systems - genetics ; Vibrio cholerae non-O1 - genetics ; Vibrio cholerae non-O1 - pathogenicity ; Vibrio cholerae O139 - genetics ; Vibrio cholerae O139 - pathogenicity ; Virulence Factors - genetics ; Waterborne diseases</subject><ispartof>Scientific reports, 2016-11, Vol.6 (1), p.36891-36891, Article 36891</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Nov 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-d58ea33cc3ca647dc41403d5d3639ce66496d4cee0b748a95f3f931fb3a007d63</citedby><cites>FETCH-LOGICAL-c438t-d58ea33cc3ca647dc41403d5d3639ce66496d4cee0b748a95f3f931fb3a007d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109276/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109276/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27845364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Labbate, Maurizio</creatorcontrib><creatorcontrib>Orata, Fabini D.</creatorcontrib><creatorcontrib>Petty, Nicola K.</creatorcontrib><creatorcontrib>Jayatilleke, Nathasha D.</creatorcontrib><creatorcontrib>King, William L.</creatorcontrib><creatorcontrib>Kirchberger, Paul C.</creatorcontrib><creatorcontrib>Allen, Chris</creatorcontrib><creatorcontrib>Mann, Gulay</creatorcontrib><creatorcontrib>Mutreja, Ankur</creatorcontrib><creatorcontrib>Thomson, Nicholas R.</creatorcontrib><creatorcontrib>Boucher, Yan</creatorcontrib><creatorcontrib>Charles, Ian G.</creatorcontrib><title>A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Cholera is a devastating diarrhoeal disease caused by certain strains of serogroup O1/O139
Vibrio cholerae
. Mobile genetic elements such as genomic islands (GIs) have been pivotal in the evolution of O1/O139
V. cholerae
. Perhaps the most important GI involved in cholera disease is the
V. cholerae
pathogenicity island 1 (VPI-1). This GI contains the toxin-coregulated pilus (TCP) gene cluster that is necessary for colonization of the human intestine as well as being the receptor for infection by the cholera-toxin bearing CTX phage. In this study, we report a GI (designated GI
Vch
S12) from a non-O1/O139 strain of
V. cholerae
that is present in the same chromosomal location as VPI-1, contains an integrase gene with 94% nucleotide and 100% protein identity to the VPI-1 integrase, and attachment (
att
) sites 100% identical to those found in VPI-1. However, instead of TCP and the other accessory genes present in VPI-1, GI
Vch
S12 contains a CRISPR-Cas element and a type VI secretion system (T6SS). GIs similar to GI
Vch
S12 were identified in other
V. cholerae
genomes, also containing CRISPR-Cas elements and/or T6SS’s. This study highlights the diversity of GIs circulating in natural
V. cholerae
populations and identifies GIs with VPI-1 recombination characteristics as a propagator of CRISPR-Cas and T6SS modules.</description><subject>45</subject><subject>45/23</subject><subject>45/29</subject><subject>45/77</subject><subject>631/326/171/1878</subject><subject>631/326/421</subject><subject>Bacterial Proteins - genetics</subject><subject>Cholera</subject><subject>Clustered Regularly Interspaced Short Palindromic Repeats</subject><subject>Colonization</subject><subject>CRISPR</subject><subject>Genomes</subject><subject>Genomic Islands</subject><subject>Humanities and Social Sciences</subject><subject>Integrase</subject><subject>Intestine</subject><subject>multidisciplinary</subject><subject>Multigene Family</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Phages</subject><subject>Recombination</subject><subject>Science</subject><subject>Secretion</subject><subject>Sequence Analysis, DNA</subject><subject>Toxins</subject><subject>Type VI Secretion Systems - genetics</subject><subject>Vibrio cholerae non-O1 - genetics</subject><subject>Vibrio cholerae non-O1 - pathogenicity</subject><subject>Vibrio cholerae O139 - genetics</subject><subject>Vibrio cholerae O139 - pathogenicity</subject><subject>Virulence Factors - genetics</subject><subject>Waterborne diseases</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkV1rFDEUhoNYbGl74R-QgDcqTE3mZD5yI5TF6kKhpereDpnMmd2UmWRMMkr_Q3-0Wbcuq-bmBM5z3vPxEvKSswvOoH4fPE5Q1pI_Iyc5E0WWQ54_P_gfk_MQ7ll6RS4Fly_IcV7VooBSnJDHS7pG60ajqQmDsh01lq5M642jeuMG9ArpTxM3dHW7zDgNJmIWJtSmTyUetRtbY1U0ziZeeaUjehOi0YFqZ6MyNtDF3fLL7V22UIFuO8SHCelqSQNqj78rR9fNA4YzctSrIeD5Uzwl364-fl18zq5vPi0Xl9eZFlDHrCtqVABag1alqDotuGDQFR2UIDWWpZBlJzQiaytRK1n00EvgfQuKsaor4ZR82OlOcztip9FGr4Zm8mZU_qFxyjR_Z6zZNGv3oyk4k3m1FXjzJODd9xlDbEYTNA7pgOjm0PAaZAVVLbfo63_Qezd7m9ZLlJQARfIiUW93lPYuJEf7_TCcNVubm73NiX11OP2e_GNqAt7tgJBSdo3-oOV_ar8A_ByzTA</recordid><startdate>20161115</startdate><enddate>20161115</enddate><creator>Labbate, Maurizio</creator><creator>Orata, Fabini D.</creator><creator>Petty, Nicola K.</creator><creator>Jayatilleke, Nathasha D.</creator><creator>King, William L.</creator><creator>Kirchberger, Paul C.</creator><creator>Allen, Chris</creator><creator>Mann, Gulay</creator><creator>Mutreja, Ankur</creator><creator>Thomson, Nicholas R.</creator><creator>Boucher, Yan</creator><creator>Charles, Ian G.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161115</creationdate><title>A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules</title><author>Labbate, Maurizio ; Orata, Fabini D. ; Petty, Nicola K. ; Jayatilleke, Nathasha D. ; King, William L. ; Kirchberger, Paul C. ; Allen, Chris ; Mann, Gulay ; Mutreja, Ankur ; Thomson, Nicholas R. ; Boucher, Yan ; Charles, Ian G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-d58ea33cc3ca647dc41403d5d3639ce66496d4cee0b748a95f3f931fb3a007d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>45</topic><topic>45/23</topic><topic>45/29</topic><topic>45/77</topic><topic>631/326/171/1878</topic><topic>631/326/421</topic><topic>Bacterial Proteins - genetics</topic><topic>Cholera</topic><topic>Clustered Regularly Interspaced Short Palindromic Repeats</topic><topic>Colonization</topic><topic>CRISPR</topic><topic>Genomes</topic><topic>Genomic Islands</topic><topic>Humanities and Social Sciences</topic><topic>Integrase</topic><topic>Intestine</topic><topic>multidisciplinary</topic><topic>Multigene Family</topic><topic>Pathogenicity</topic><topic>Pathogens</topic><topic>Phages</topic><topic>Recombination</topic><topic>Science</topic><topic>Secretion</topic><topic>Sequence Analysis, DNA</topic><topic>Toxins</topic><topic>Type VI Secretion Systems - genetics</topic><topic>Vibrio cholerae non-O1 - genetics</topic><topic>Vibrio cholerae non-O1 - pathogenicity</topic><topic>Vibrio cholerae O139 - genetics</topic><topic>Vibrio cholerae O139 - pathogenicity</topic><topic>Virulence Factors - genetics</topic><topic>Waterborne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Labbate, Maurizio</creatorcontrib><creatorcontrib>Orata, Fabini D.</creatorcontrib><creatorcontrib>Petty, Nicola K.</creatorcontrib><creatorcontrib>Jayatilleke, Nathasha D.</creatorcontrib><creatorcontrib>King, William L.</creatorcontrib><creatorcontrib>Kirchberger, Paul C.</creatorcontrib><creatorcontrib>Allen, Chris</creatorcontrib><creatorcontrib>Mann, Gulay</creatorcontrib><creatorcontrib>Mutreja, Ankur</creatorcontrib><creatorcontrib>Thomson, Nicholas R.</creatorcontrib><creatorcontrib>Boucher, Yan</creatorcontrib><creatorcontrib>Charles, Ian G.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Labbate, Maurizio</au><au>Orata, Fabini D.</au><au>Petty, Nicola K.</au><au>Jayatilleke, Nathasha D.</au><au>King, William L.</au><au>Kirchberger, Paul C.</au><au>Allen, Chris</au><au>Mann, Gulay</au><au>Mutreja, Ankur</au><au>Thomson, Nicholas R.</au><au>Boucher, Yan</au><au>Charles, Ian G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-11-15</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>36891</spage><epage>36891</epage><pages>36891-36891</pages><artnum>36891</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Cholera is a devastating diarrhoeal disease caused by certain strains of serogroup O1/O139
Vibrio cholerae
. Mobile genetic elements such as genomic islands (GIs) have been pivotal in the evolution of O1/O139
V. cholerae
. Perhaps the most important GI involved in cholera disease is the
V. cholerae
pathogenicity island 1 (VPI-1). This GI contains the toxin-coregulated pilus (TCP) gene cluster that is necessary for colonization of the human intestine as well as being the receptor for infection by the cholera-toxin bearing CTX phage. In this study, we report a GI (designated GI
Vch
S12) from a non-O1/O139 strain of
V. cholerae
that is present in the same chromosomal location as VPI-1, contains an integrase gene with 94% nucleotide and 100% protein identity to the VPI-1 integrase, and attachment (
att
) sites 100% identical to those found in VPI-1. However, instead of TCP and the other accessory genes present in VPI-1, GI
Vch
S12 contains a CRISPR-Cas element and a type VI secretion system (T6SS). GIs similar to GI
Vch
S12 were identified in other
V. cholerae
genomes, also containing CRISPR-Cas elements and/or T6SS’s. This study highlights the diversity of GIs circulating in natural
V. cholerae
populations and identifies GIs with VPI-1 recombination characteristics as a propagator of CRISPR-Cas and T6SS modules.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27845364</pmid><doi>10.1038/srep36891</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Scientific reports, 2016-11, Vol.6 (1), p.36891-36891, Article 36891 |
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| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 45 45/23 45/29 45/77 631/326/171/1878 631/326/421 Bacterial Proteins - genetics Cholera Clustered Regularly Interspaced Short Palindromic Repeats Colonization CRISPR Genomes Genomic Islands Humanities and Social Sciences Integrase Intestine multidisciplinary Multigene Family Pathogenicity Pathogens Phages Recombination Science Secretion Sequence Analysis, DNA Toxins Type VI Secretion Systems - genetics Vibrio cholerae non-O1 - genetics Vibrio cholerae non-O1 - pathogenicity Vibrio cholerae O139 - genetics Vibrio cholerae O139 - pathogenicity Virulence Factors - genetics Waterborne diseases |
| title | A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules |
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