A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells

DNGR‐1 is receptor expressed by certain dendritic cell (DC) subsets and by DC precursors in mouse. It possesses a C‐type lectin‐like domain (CTLD) followed by a poorly characterized neck region coupled to a transmembrane region and short intracellular tail. The CTLD of DNGR‐1 binds F‐actin exposed b...

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Veröffentlicht in:	The EMBO journal 2016-11, Vol.35 (22), p.2484-2497
Hauptverfasser:	Hanč, Pavel, Schulz, Oliver, Fischbach, Hanna, Martin, Stephen R, Kjær, Svend, Reis e Sousa, Caetano
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animals Antigens C-type lectin receptors cross-presentation Dendritic cells Dendritic Cells - metabolism DNA Mutational Analysis EMBO19 Hydrogen-Ion Concentration Lectins, C-Type - chemistry Lectins, C-Type - genetics Lectins, C-Type - metabolism Mice necrosis Osmolar Concentration Protein Conformation - drug effects protein structure Receptors, Immunologic - chemistry Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Rodents
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