Platelet Integrin αIIbβ3 Inhibitor Rescues Progression of Apoptosis in Human Platelets

BACKGROUND Apoptosis plays an important role in the physiology of platelet function. We aimed to detect the effect of the platelet integrin αIIbβ3 inhibitor, tirofiban, on apoptotic events, including mitochondrial inner-membrane potential (ΔΨm), phosphatidylserine (PS) exposure on platelet surface,...

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Veröffentlicht in:	Medical science monitor 2016-11, Vol.22, p.4261-4270
Hauptverfasser:	Zhu, Jie, Wang, Qinghang, Nie, Yumei, Yan, Rong, Dai, Kesheng, Zhou, Birong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis - drug effects Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - metabolism Female Humans Lab/In Vitro Research Male Membrane Potential, Mitochondrial Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Reactive Oxygen Species - metabolism Thrombin - metabolism Tirofiban Tyrosine - analogs & derivatives Tyrosine - pharmacology
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