Antitherapeutic antibody-mediated hepatotoxicity of recombinant human Apo2L/TRAIL in the cynomolgus monkey

Apo2L/TRAIL is a member of the tumor necrosis factor superfamily and an important inducer of apoptosis. Recombinant human (rhu) Apo2L/TRAIL has been attractive as a potential cancer therapeutic because many types of tumor cells are sensitive to its apoptosis-inducing effects. Nonclinical toxicology...

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Veröffentlicht in:	Cell death & disease 2016-08, Vol.7 (8), p.e2338-e2338
Hauptverfasser:	Zuch de Zafra, Christina L, Ashkenazi, Avi, Darbonne, Walter C, Cheu, Melissa, Totpal, Klara, Ortega, Shirley, Flores, Heather, Walker, Mark D, Kabakoff, Bruce, Lum, Bert L, Mounho-Zamora, Barbara J, Marsters, Scot A, Dybdal, Noël O
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/2 13/51 631/80/82/23 692/4020/4021/1607/2749 692/699/67/1059 692/700/565/2194 Animals Antibodies Antibodies - therapeutic use Antibodies - toxicity Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Disease Models, Animal Humans Immunology Jurkat Cells Kidney - drug effects Kidney - pathology Life Sciences Liver Liver - drug effects Liver - pathology Macaca fascicularis Monkeys & apes Original original-article Protein expression Recombinant Proteins - therapeutic use Recombinant Proteins - toxicity Species Specificity TNF-Related Apoptosis-Inducing Ligand - therapeutic use TNF-Related Apoptosis-Inducing Ligand - toxicity Toxicity
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