Increased chemotaxis and activity of circulatory myeloid progenitor cells may contribute to enhanced osteoclastogenesis and bone loss in the C57BL/6 mouse model of collagen‐induced arthritis

Summary Our study aimed to determine the functional activity of different osteoclast progenitor (OCP) subpopulations and signals important for their migration to bone lesions, causing local and systemic bone resorption during the course of collagen‐induced arthritis in C57BL/6 mice. Arthritis was in...

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Veröffentlicht in:	Clinical and experimental immunology 2016-12, Vol.186 (3), p.321-335
Hauptverfasser:	Ikić Matijašević, M., Flegar, D., Kovačić, N., Katavić, V., Kelava, T., Šućur, A., Ivčević, S., Cvija, H., Lazić Mosler, E., Kalajzić, I., Marušić, A., Grčević, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Arthritis, Experimental - diagnosis Arthritis, Experimental - etiology Arthritis, Experimental - metabolism Autoantibodies - immunology Biomarkers Biopsy bone loss Bone marrow Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Bone Resorption - diagnostic imaging Bone Resorption - etiology Bone Resorption - pathology Cell Differentiation chemokines Chemotaxis - immunology Collagen Collagen Type II - immunology collagen‐induced arthritis Cytokines - metabolism Disease Models, Animal Immunophenotyping inflammation Male Mice Mice, Inbred C57BL Myeloid Progenitor Cells - cytology Myeloid Progenitor Cells - immunology Myeloid Progenitor Cells - metabolism Original osteoclast progenitors Osteoclasts - metabolism Phenotype Rodents X-Ray Microtomography
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