Alcohol consumption and mortality in patients undergoing coronary artery bypass graft (CABG)-a register-based cohort study
Previous studies have shown that compared with abstinence and heavy drinking, moderate alcohol consumption is associated with a reduced risk of mortality among the general population and patients with heart failure and myocardial infarction. We examined the association between alcohol consumption an...
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| Veröffentlicht in: | BMC cardiovascular disorders 2016-11, Vol.16 (1), p.219-219, Article 219 |
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| creator | Grabas, Mads Phillip Kofoed Hansen, Steen Møller Torp-Pedersen, Christian Bøggild, Henrik Ullits, Line Rosenkilde Deding, Ulrik Nielsen, Berit Jamie Jensen, Per Føge Overgaard, Charlotte |
| description | Previous studies have shown that compared with abstinence and heavy drinking, moderate alcohol consumption is associated with a reduced risk of mortality among the general population and patients with heart failure and myocardial infarction. We examined the association between alcohol consumption and mortality in coronary artery bypass graft (CABG) patients.
We studied 1,919 first-time CABG patients using data on alcohol consumption and mortality obtained from Danish national registers from March 2006 to October 2011. Alcohol consumption was divided into the following groups: abstainers (0 units/week), moderate consumers (1-14 units/week), moderate-heavy drinkers (15-21 units/week) and heavy drinkers (>21 units/week). Hazard ratios (HR) of all-cause mortality were calculated using Cox proportional hazard regression analysis.
The median follow-up was 2.2 years [IQR 2.0]. There were 112 deaths, of which 96 (86 %) were classified as cardiovascular. Adjustments for age and sex showed no increased risk of all-cause mortality for the abstainers (HR 1.61, 95 % CI, 1.00-2.58) and moderate-heavy drinkers (HR 1.40, 95 % CI, 0.73-2.67) compared with moderate consumers. However, heavy drinkers had a high risk of all-cause mortality compared with moderate consumers (HR 2.44, 95 % CI, 1.47-4.04). A full adjustment showed no increase in mortality for the abstainers (HR 1.59, 95 % CI, 0.98-2.57) and moderate-heavy drinkers (HR 1.68, 95 % CI, 0.86-3.29), while heavy drinkers were associated with an increased mortality rate (HR 1.88, 95 % CI, 1.10-3.21). There was no increased risk of 30-day mortality for the abstainers (HR 0.74, 95 % CI, 0.23-2.32), moderate-heavy drinkers (HR 0.36, 95 % CI, 0.07-1.93) and heavy drinkers (HR 2.20, 95 % CI, 0.65-7.36).
There was no increased risk of mortality for abstainers (0 units/week) or moderate-heavy drinkers (15-21 units/week) following a CABG. Only heavy drinking (>21 units/week) were significantly associated with an increased mortality rate. These results suggest that only heavy drinking present a risk factor among CABG patients. |
| doi_str_mv | 10.1186/s12872-016-0403-3 |
| format | Article |
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We studied 1,919 first-time CABG patients using data on alcohol consumption and mortality obtained from Danish national registers from March 2006 to October 2011. Alcohol consumption was divided into the following groups: abstainers (0 units/week), moderate consumers (1-14 units/week), moderate-heavy drinkers (15-21 units/week) and heavy drinkers (>21 units/week). Hazard ratios (HR) of all-cause mortality were calculated using Cox proportional hazard regression analysis.
The median follow-up was 2.2 years [IQR 2.0]. There were 112 deaths, of which 96 (86 %) were classified as cardiovascular. Adjustments for age and sex showed no increased risk of all-cause mortality for the abstainers (HR 1.61, 95 % CI, 1.00-2.58) and moderate-heavy drinkers (HR 1.40, 95 % CI, 0.73-2.67) compared with moderate consumers. However, heavy drinkers had a high risk of all-cause mortality compared with moderate consumers (HR 2.44, 95 % CI, 1.47-4.04). A full adjustment showed no increase in mortality for the abstainers (HR 1.59, 95 % CI, 0.98-2.57) and moderate-heavy drinkers (HR 1.68, 95 % CI, 0.86-3.29), while heavy drinkers were associated with an increased mortality rate (HR 1.88, 95 % CI, 1.10-3.21). There was no increased risk of 30-day mortality for the abstainers (HR 0.74, 95 % CI, 0.23-2.32), moderate-heavy drinkers (HR 0.36, 95 % CI, 0.07-1.93) and heavy drinkers (HR 2.20, 95 % CI, 0.65-7.36).
There was no increased risk of mortality for abstainers (0 units/week) or moderate-heavy drinkers (15-21 units/week) following a CABG. Only heavy drinking (>21 units/week) were significantly associated with an increased mortality rate. These results suggest that only heavy drinking present a risk factor among CABG patients.</description><identifier>ISSN: 1471-2261</identifier><identifier>EISSN: 1471-2261</identifier><identifier>DOI: 10.1186/s12872-016-0403-3</identifier><identifier>PMID: 27835965</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alcohol Abstinence ; Alcohol Drinking - adverse effects ; Alcohol Drinking - mortality ; Alcohol Drinking - prevention & control ; Alcoholism - mortality ; Alcoholism - prevention & control ; Chi-Square Distribution ; Coronary artery bypass ; Coronary Artery Bypass - adverse effects ; Coronary Artery Bypass - mortality ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - mortality ; Coronary Artery Disease - surgery ; Denmark ; Denmark - epidemiology ; Drinking of alcoholic beverages ; Female ; Health aspects ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Mortality ; Multivariate Analysis ; Proportional Hazards Models ; Registries ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome</subject><ispartof>BMC cardiovascular disorders, 2016-11, Vol.16 (1), p.219-219, Article 219</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-997d2720002e3201777232defd8a2f4d3c9b1e8e34930e27342169655b15e39e3</citedby><cites>FETCH-LOGICAL-c494t-997d2720002e3201777232defd8a2f4d3c9b1e8e34930e27342169655b15e39e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105266/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105266/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27835965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grabas, Mads Phillip Kofoed</creatorcontrib><creatorcontrib>Hansen, Steen Møller</creatorcontrib><creatorcontrib>Torp-Pedersen, Christian</creatorcontrib><creatorcontrib>Bøggild, Henrik</creatorcontrib><creatorcontrib>Ullits, Line Rosenkilde</creatorcontrib><creatorcontrib>Deding, Ulrik</creatorcontrib><creatorcontrib>Nielsen, Berit Jamie</creatorcontrib><creatorcontrib>Jensen, Per Føge</creatorcontrib><creatorcontrib>Overgaard, Charlotte</creatorcontrib><title>Alcohol consumption and mortality in patients undergoing coronary artery bypass graft (CABG)-a register-based cohort study</title><title>BMC cardiovascular disorders</title><addtitle>BMC Cardiovasc Disord</addtitle><description>Previous studies have shown that compared with abstinence and heavy drinking, moderate alcohol consumption is associated with a reduced risk of mortality among the general population and patients with heart failure and myocardial infarction. We examined the association between alcohol consumption and mortality in coronary artery bypass graft (CABG) patients.
We studied 1,919 first-time CABG patients using data on alcohol consumption and mortality obtained from Danish national registers from March 2006 to October 2011. Alcohol consumption was divided into the following groups: abstainers (0 units/week), moderate consumers (1-14 units/week), moderate-heavy drinkers (15-21 units/week) and heavy drinkers (>21 units/week). Hazard ratios (HR) of all-cause mortality were calculated using Cox proportional hazard regression analysis.
The median follow-up was 2.2 years [IQR 2.0]. There were 112 deaths, of which 96 (86 %) were classified as cardiovascular. Adjustments for age and sex showed no increased risk of all-cause mortality for the abstainers (HR 1.61, 95 % CI, 1.00-2.58) and moderate-heavy drinkers (HR 1.40, 95 % CI, 0.73-2.67) compared with moderate consumers. However, heavy drinkers had a high risk of all-cause mortality compared with moderate consumers (HR 2.44, 95 % CI, 1.47-4.04). A full adjustment showed no increase in mortality for the abstainers (HR 1.59, 95 % CI, 0.98-2.57) and moderate-heavy drinkers (HR 1.68, 95 % CI, 0.86-3.29), while heavy drinkers were associated with an increased mortality rate (HR 1.88, 95 % CI, 1.10-3.21). There was no increased risk of 30-day mortality for the abstainers (HR 0.74, 95 % CI, 0.23-2.32), moderate-heavy drinkers (HR 0.36, 95 % CI, 0.07-1.93) and heavy drinkers (HR 2.20, 95 % CI, 0.65-7.36).
There was no increased risk of mortality for abstainers (0 units/week) or moderate-heavy drinkers (15-21 units/week) following a CABG. Only heavy drinking (>21 units/week) were significantly associated with an increased mortality rate. These results suggest that only heavy drinking present a risk factor among CABG patients.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcohol Abstinence</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - mortality</subject><subject>Alcohol Drinking - prevention & control</subject><subject>Alcoholism - mortality</subject><subject>Alcoholism - prevention & control</subject><subject>Chi-Square Distribution</subject><subject>Coronary artery bypass</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Coronary Artery Bypass - mortality</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary Artery Disease - surgery</subject><subject>Denmark</subject><subject>Denmark - epidemiology</subject><subject>Drinking of alcoholic beverages</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Proportional Hazards Models</subject><subject>Registries</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1471-2261</issn><issn>1471-2261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUsFu1DAUjBCIlsIHcEGWuJRDip_txPEFaVlBQarEBc6WE7-krhJ7sZ1Ky9fj1ZbSIuTDs_xm5nnsqarXQC8AuvZ9AtZJVlNoayoor_mT6hSEhJqxFp4-2J9UL1K6oRRkR9Xz6oTJjjeqbU6rX5t5CNdhJkPwaV122QVPjLdkCTGb2eU9cZ7sTHbocyKrtxin4PxUCDF4E_fExIyl9PudSYlM0YyZnG83Hy_f1YZEnFwq_bo3CS05zIqZpLza_cvq2WjmhK_u6ln14_On79sv9dW3y6_bzVU9CCVyrZS0TDJKKUPOigUpGWcWR9sZNgrLB9UDdsiF4hSZ5IJBW7w1PTTIFfKz6sNRd7f2C9qhGIlm1rvolnJ9HYzTjzveXesp3OoGaMPatgic3wnE8HPFlPXi0oDzbDyGNWnouAJgDWMF-vYf6E1Yoy_2Cko0IJSi8Bc1mRm182Moc4eDqN6IVnUtSFAFdfEfVFkWF1e-C0dXzh8R4EgYYkgp4njvEag-BEYfA6NLYPQhMJoXzpuHj3PP-JMQ_huLI7so</recordid><startdate>20161111</startdate><enddate>20161111</enddate><creator>Grabas, Mads Phillip Kofoed</creator><creator>Hansen, Steen Møller</creator><creator>Torp-Pedersen, Christian</creator><creator>Bøggild, Henrik</creator><creator>Ullits, Line Rosenkilde</creator><creator>Deding, Ulrik</creator><creator>Nielsen, Berit Jamie</creator><creator>Jensen, Per Føge</creator><creator>Overgaard, Charlotte</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161111</creationdate><title>Alcohol consumption and mortality in patients undergoing coronary artery bypass graft (CABG)-a register-based cohort study</title><author>Grabas, Mads Phillip Kofoed ; Hansen, Steen Møller ; Torp-Pedersen, Christian ; Bøggild, Henrik ; Ullits, Line Rosenkilde ; Deding, Ulrik ; Nielsen, Berit Jamie ; Jensen, Per Føge ; Overgaard, Charlotte</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-997d2720002e3201777232defd8a2f4d3c9b1e8e34930e27342169655b15e39e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcohol Abstinence</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - mortality</topic><topic>Alcohol Drinking - prevention & control</topic><topic>Alcoholism - mortality</topic><topic>Alcoholism - prevention & control</topic><topic>Chi-Square Distribution</topic><topic>Coronary artery bypass</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Coronary Artery Bypass - mortality</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - mortality</topic><topic>Coronary Artery Disease - surgery</topic><topic>Denmark</topic><topic>Denmark - epidemiology</topic><topic>Drinking of alcoholic beverages</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multivariate Analysis</topic><topic>Proportional Hazards Models</topic><topic>Registries</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grabas, Mads Phillip Kofoed</creatorcontrib><creatorcontrib>Hansen, Steen Møller</creatorcontrib><creatorcontrib>Torp-Pedersen, Christian</creatorcontrib><creatorcontrib>Bøggild, Henrik</creatorcontrib><creatorcontrib>Ullits, Line Rosenkilde</creatorcontrib><creatorcontrib>Deding, Ulrik</creatorcontrib><creatorcontrib>Nielsen, Berit Jamie</creatorcontrib><creatorcontrib>Jensen, Per Føge</creatorcontrib><creatorcontrib>Overgaard, Charlotte</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC cardiovascular disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grabas, Mads Phillip Kofoed</au><au>Hansen, Steen Møller</au><au>Torp-Pedersen, Christian</au><au>Bøggild, Henrik</au><au>Ullits, Line Rosenkilde</au><au>Deding, Ulrik</au><au>Nielsen, Berit Jamie</au><au>Jensen, Per Føge</au><au>Overgaard, Charlotte</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol consumption and mortality in patients undergoing coronary artery bypass graft (CABG)-a register-based cohort study</atitle><jtitle>BMC cardiovascular disorders</jtitle><addtitle>BMC Cardiovasc Disord</addtitle><date>2016-11-11</date><risdate>2016</risdate><volume>16</volume><issue>1</issue><spage>219</spage><epage>219</epage><pages>219-219</pages><artnum>219</artnum><issn>1471-2261</issn><eissn>1471-2261</eissn><abstract>Previous studies have shown that compared with abstinence and heavy drinking, moderate alcohol consumption is associated with a reduced risk of mortality among the general population and patients with heart failure and myocardial infarction. We examined the association between alcohol consumption and mortality in coronary artery bypass graft (CABG) patients.
We studied 1,919 first-time CABG patients using data on alcohol consumption and mortality obtained from Danish national registers from March 2006 to October 2011. Alcohol consumption was divided into the following groups: abstainers (0 units/week), moderate consumers (1-14 units/week), moderate-heavy drinkers (15-21 units/week) and heavy drinkers (>21 units/week). Hazard ratios (HR) of all-cause mortality were calculated using Cox proportional hazard regression analysis.
The median follow-up was 2.2 years [IQR 2.0]. There were 112 deaths, of which 96 (86 %) were classified as cardiovascular. Adjustments for age and sex showed no increased risk of all-cause mortality for the abstainers (HR 1.61, 95 % CI, 1.00-2.58) and moderate-heavy drinkers (HR 1.40, 95 % CI, 0.73-2.67) compared with moderate consumers. However, heavy drinkers had a high risk of all-cause mortality compared with moderate consumers (HR 2.44, 95 % CI, 1.47-4.04). A full adjustment showed no increase in mortality for the abstainers (HR 1.59, 95 % CI, 0.98-2.57) and moderate-heavy drinkers (HR 1.68, 95 % CI, 0.86-3.29), while heavy drinkers were associated with an increased mortality rate (HR 1.88, 95 % CI, 1.10-3.21). There was no increased risk of 30-day mortality for the abstainers (HR 0.74, 95 % CI, 0.23-2.32), moderate-heavy drinkers (HR 0.36, 95 % CI, 0.07-1.93) and heavy drinkers (HR 2.20, 95 % CI, 0.65-7.36).
There was no increased risk of mortality for abstainers (0 units/week) or moderate-heavy drinkers (15-21 units/week) following a CABG. Only heavy drinking (>21 units/week) were significantly associated with an increased mortality rate. These results suggest that only heavy drinking present a risk factor among CABG patients.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27835965</pmid><doi>10.1186/s12872-016-0403-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Springer Nature OA Free Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Aged Aged, 80 and over Alcohol Abstinence Alcohol Drinking - adverse effects Alcohol Drinking - mortality Alcohol Drinking - prevention & control Alcoholism - mortality Alcoholism - prevention & control Chi-Square Distribution Coronary artery bypass Coronary Artery Bypass - adverse effects Coronary Artery Bypass - mortality Coronary Artery Disease - diagnosis Coronary Artery Disease - mortality Coronary Artery Disease - surgery Denmark Denmark - epidemiology Drinking of alcoholic beverages Female Health aspects Humans Kaplan-Meier Estimate Male Middle Aged Mortality Multivariate Analysis Proportional Hazards Models Registries Risk Assessment Risk Factors Time Factors Treatment Outcome |
| title | Alcohol consumption and mortality in patients undergoing coronary artery bypass graft (CABG)-a register-based cohort study |
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