Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change
To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health...
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| Veröffentlicht in: | BMC musculoskeletal disorders 2016-11, Vol.17 (1), p.466-466, Article 466 |
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| creator | Roemer, Frank W Guermazi, Ali Collins, Jamie E Losina, Elena Nevitt, Michael C Lynch, John A Katz, Jeffrey N Kwoh, C Kent Kraus, Virginia B Hunter, David J |
| description | To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium study nested within the larger Osteoarthritis Initiative (OAI) Study.
We conducted a nested case-control study. Cases (n = 406) were knees having both radiographic and pain progression. Controls (n = 194) were knee osteoarthritis subjects who did not meet the case definition. Groups were matched for Kellgren-Lawrence grade and body mass index. MRIs were acquired using 3 T MRI systems and assessed using the semi-quantitative MOAKS system. MRIs were read at baseline and 24 months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. We provide the definition and distribution of change in these biomarkers over time.
Seventy-three percent of the cases had subregions with BML worsening (vs. 66 % in controls) (p = 0.102). Little change in osteophytes was seen over 24 months. Twenty-eight percent of cases and 10 % of controls had worsening in meniscal scores in at least one subregion (p |
| doi_str_mv | 10.1186/s12891-016-1310-6 |
| format | Article |
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We conducted a nested case-control study. Cases (n = 406) were knees having both radiographic and pain progression. Controls (n = 194) were knee osteoarthritis subjects who did not meet the case definition. Groups were matched for Kellgren-Lawrence grade and body mass index. MRIs were acquired using 3 T MRI systems and assessed using the semi-quantitative MOAKS system. MRIs were read at baseline and 24 months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. We provide the definition and distribution of change in these biomarkers over time.
Seventy-three percent of the cases had subregions with BML worsening (vs. 66 % in controls) (p = 0.102). Little change in osteophytes was seen over 24 months. Twenty-eight percent of cases and 10 % of controls had worsening in meniscal scores in at least one subregion (p < 0.001). Seventy-three percent of cases and 53 % of controls had at least one area with worsening in cartilage surface area (p < 0.001). More cases experienced worsening in Hoffa- and effusion synovitis than controls (17 % vs. 6 % (p < 0.001); 41 % vs. 18 % (p < 0.001), respectively).
A wide range of MRI-detected structural pathologies was present in the FNIH cohort. More severe changes, especially for BMLs, cartilage and meniscal damage, were detected primarily among the case group suggesting that early changes in multiple structural domains are associated with radiographic worsening and symptomatic progression.</description><identifier>ISSN: 1471-2474</identifier><identifier>EISSN: 1471-2474</identifier><identifier>DOI: 10.1186/s12891-016-1310-6</identifier><identifier>PMID: 27832771</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Arthritis ; Biological markers ; Biomarkers ; Bone marrow ; Bone Marrow - diagnostic imaging ; Cartilage ; Cartilage, Articular - diagnostic imaging ; Case-Control Studies ; Cohort analysis ; Development and progression ; Disease Progression ; Diseases ; Female ; Humans ; Knee ; Magnetic Resonance Imaging ; Male ; Menisci, Tibial - diagnostic imaging ; Middle Aged ; Morphology ; Musculoskeletal diseases ; Osteoarthritis ; Osteoarthritis, Knee - diagnostic imaging ; Osteophyte - diagnostic imaging ; Pain ; Synovitis - diagnostic imaging</subject><ispartof>BMC musculoskeletal disorders, 2016-11, Vol.17 (1), p.466-466, Article 466</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-83d08f69f5b86f5917fd1b5beac33f0c79923f2ad8cd233278df8da67485a14a3</citedby><cites>FETCH-LOGICAL-c494t-83d08f69f5b86f5917fd1b5beac33f0c79923f2ad8cd233278df8da67485a14a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105263/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105263/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27832771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roemer, Frank W</creatorcontrib><creatorcontrib>Guermazi, Ali</creatorcontrib><creatorcontrib>Collins, Jamie E</creatorcontrib><creatorcontrib>Losina, Elena</creatorcontrib><creatorcontrib>Nevitt, Michael C</creatorcontrib><creatorcontrib>Lynch, John A</creatorcontrib><creatorcontrib>Katz, Jeffrey N</creatorcontrib><creatorcontrib>Kwoh, C Kent</creatorcontrib><creatorcontrib>Kraus, Virginia B</creatorcontrib><creatorcontrib>Hunter, David J</creatorcontrib><title>Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change</title><title>BMC musculoskeletal disorders</title><addtitle>BMC Musculoskelet Disord</addtitle><description>To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium study nested within the larger Osteoarthritis Initiative (OAI) Study.
We conducted a nested case-control study. Cases (n = 406) were knees having both radiographic and pain progression. Controls (n = 194) were knee osteoarthritis subjects who did not meet the case definition. Groups were matched for Kellgren-Lawrence grade and body mass index. MRIs were acquired using 3 T MRI systems and assessed using the semi-quantitative MOAKS system. MRIs were read at baseline and 24 months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. We provide the definition and distribution of change in these biomarkers over time.
Seventy-three percent of the cases had subregions with BML worsening (vs. 66 % in controls) (p = 0.102). Little change in osteophytes was seen over 24 months. Twenty-eight percent of cases and 10 % of controls had worsening in meniscal scores in at least one subregion (p < 0.001). Seventy-three percent of cases and 53 % of controls had at least one area with worsening in cartilage surface area (p < 0.001). More cases experienced worsening in Hoffa- and effusion synovitis than controls (17 % vs. 6 % (p < 0.001); 41 % vs. 18 % (p < 0.001), respectively).
A wide range of MRI-detected structural pathologies was present in the FNIH cohort. More severe changes, especially for BMLs, cartilage and meniscal damage, were detected primarily among the case group suggesting that early changes in multiple structural domains are associated with radiographic worsening and symptomatic progression.</description><subject>Aged</subject><subject>Arthritis</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Bone marrow</subject><subject>Bone Marrow - diagnostic imaging</subject><subject>Cartilage</subject><subject>Cartilage, Articular - diagnostic imaging</subject><subject>Case-Control Studies</subject><subject>Cohort analysis</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Knee</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Menisci, Tibial - diagnostic imaging</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Musculoskeletal diseases</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - diagnostic imaging</subject><subject>Osteophyte - diagnostic imaging</subject><subject>Pain</subject><subject>Synovitis - diagnostic imaging</subject><issn>1471-2474</issn><issn>1471-2474</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUstuFDEQHCEQCYEP4IIsceEywR7P2J4LUhQlZKU8JB5ny-PHjpNZe2N7InHjyl_wbXwJvdoQNghZVrfsqmp1d1XVa4IPCRHsfSaN6EmNCasJJbhmT6p90nJSNy1vn-7ke9WLnK8xJlzQ_nm110BsOCf71c_PduXr21mF4osq_s6ii08LNPi4UunGpoyiQzfBWhRzsVGlMiZffEbrFJfJ5uxjQD6gMlp0erk422XqGHJMxc8rSEfIfn3_UcO9sGWMJk5x6TVSeW11yUgFg4x1PoA6SEJVPaqwtC-rZ05N2b66jwfV19OTL8dn9fnVx8Xx0Xmt274ttaAGC8d61w2Cua4n3BkydINVmlKHNe_7hrpGGaFNQ6F5YZwwivFWdIq0ih5UH7a663lYWaNtKElNcp08tPNNRuXl45_gR7mMd7IjuGsYBYF39wIp3s42F7nyWdtpUsHGOUsCoyeEcdYD9O0_0Os4pwDtAartqOgw439RSzVZ6YOLUFdvROVRy3qBG960gDr8DwqOgcXCBmCk8P6IQLYEnWLOybqHHgmWG1vJra0k2EpubCUZcN7sDueB8cdH9DdJQs0v</recordid><startdate>20161110</startdate><enddate>20161110</enddate><creator>Roemer, Frank W</creator><creator>Guermazi, Ali</creator><creator>Collins, Jamie E</creator><creator>Losina, Elena</creator><creator>Nevitt, Michael C</creator><creator>Lynch, John A</creator><creator>Katz, Jeffrey N</creator><creator>Kwoh, C Kent</creator><creator>Kraus, Virginia B</creator><creator>Hunter, David J</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161110</creationdate><title>Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change</title><author>Roemer, Frank W ; Guermazi, Ali ; Collins, Jamie E ; Losina, Elena ; Nevitt, Michael C ; Lynch, John A ; Katz, Jeffrey N ; Kwoh, C Kent ; Kraus, Virginia B ; Hunter, David J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-83d08f69f5b86f5917fd1b5beac33f0c79923f2ad8cd233278df8da67485a14a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Arthritis</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Bone marrow</topic><topic>Bone Marrow - diagnostic imaging</topic><topic>Cartilage</topic><topic>Cartilage, Articular - diagnostic imaging</topic><topic>Case-Control Studies</topic><topic>Cohort analysis</topic><topic>Development and progression</topic><topic>Disease Progression</topic><topic>Diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Knee</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Menisci, Tibial - diagnostic imaging</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Musculoskeletal diseases</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - diagnostic imaging</topic><topic>Osteophyte - diagnostic imaging</topic><topic>Pain</topic><topic>Synovitis - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roemer, Frank W</creatorcontrib><creatorcontrib>Guermazi, Ali</creatorcontrib><creatorcontrib>Collins, Jamie E</creatorcontrib><creatorcontrib>Losina, Elena</creatorcontrib><creatorcontrib>Nevitt, Michael C</creatorcontrib><creatorcontrib>Lynch, John A</creatorcontrib><creatorcontrib>Katz, Jeffrey N</creatorcontrib><creatorcontrib>Kwoh, C Kent</creatorcontrib><creatorcontrib>Kraus, Virginia B</creatorcontrib><creatorcontrib>Hunter, David J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC musculoskeletal disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roemer, Frank W</au><au>Guermazi, Ali</au><au>Collins, Jamie E</au><au>Losina, Elena</au><au>Nevitt, Michael C</au><au>Lynch, John A</au><au>Katz, Jeffrey N</au><au>Kwoh, C Kent</au><au>Kraus, Virginia B</au><au>Hunter, David J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change</atitle><jtitle>BMC musculoskeletal disorders</jtitle><addtitle>BMC Musculoskelet Disord</addtitle><date>2016-11-10</date><risdate>2016</risdate><volume>17</volume><issue>1</issue><spage>466</spage><epage>466</epage><pages>466-466</pages><artnum>466</artnum><issn>1471-2474</issn><eissn>1471-2474</eissn><abstract>To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium study nested within the larger Osteoarthritis Initiative (OAI) Study.
We conducted a nested case-control study. Cases (n = 406) were knees having both radiographic and pain progression. Controls (n = 194) were knee osteoarthritis subjects who did not meet the case definition. Groups were matched for Kellgren-Lawrence grade and body mass index. MRIs were acquired using 3 T MRI systems and assessed using the semi-quantitative MOAKS system. MRIs were read at baseline and 24 months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. We provide the definition and distribution of change in these biomarkers over time.
Seventy-three percent of the cases had subregions with BML worsening (vs. 66 % in controls) (p = 0.102). Little change in osteophytes was seen over 24 months. Twenty-eight percent of cases and 10 % of controls had worsening in meniscal scores in at least one subregion (p < 0.001). Seventy-three percent of cases and 53 % of controls had at least one area with worsening in cartilage surface area (p < 0.001). More cases experienced worsening in Hoffa- and effusion synovitis than controls (17 % vs. 6 % (p < 0.001); 41 % vs. 18 % (p < 0.001), respectively).
A wide range of MRI-detected structural pathologies was present in the FNIH cohort. More severe changes, especially for BMLs, cartilage and meniscal damage, were detected primarily among the case group suggesting that early changes in multiple structural domains are associated with radiographic worsening and symptomatic progression.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27832771</pmid><doi>10.1186/s12891-016-1310-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Arthritis Biological markers Biomarkers Bone marrow Bone Marrow - diagnostic imaging Cartilage Cartilage, Articular - diagnostic imaging Case-Control Studies Cohort analysis Development and progression Disease Progression Diseases Female Humans Knee Magnetic Resonance Imaging Male Menisci, Tibial - diagnostic imaging Middle Aged Morphology Musculoskeletal diseases Osteoarthritis Osteoarthritis, Knee - diagnostic imaging Osteophyte - diagnostic imaging Pain Synovitis - diagnostic imaging |
| title | Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change |
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