Molecular Basis for Recognition of the Cancer Glycobiomarker, LacdiNAc (GalNAc[β1→4]GlcNAc), by Wisteria floribunda Agglutinin

Aberrant glycosylation and the overexpression of specific carbohydrate epitopes is a hallmark of many cancers, and tumor-associated oligosaccharides are actively investigated as targets for immunotherapy and diagnostics. Wisteria floribunda agglutinin (WFA) is a legume lectin that recognizes termina...

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Veröffentlicht in:	The Journal of biological chemistry 2016-11, Vol.291 (46), p.24085-24095
Hauptverfasser:	Haji-Ghassemi, Omid, Gilbert, Michel, Spence, Jenifer, Schur, Melissa J., Parker, Matthew J., Jenkins, Meredith L., Burke, John E., van Faassen, Henk, Young, N. Martin, Evans, Stephen V.
Format:	Artikel
Sprache:	eng
Schlagworte:	agglutinin biomarker Biomarkers, Tumor - chemistry cancer carbohydrate carbohydrate-binding protein Crystallography, X-Ray Glycobiology and Extracellular Matrices glycobiomarker Humans Lactose - analogs & derivatives Lactose - chemistry lectin Plant Lectins - chemistry Protein Binding Protein Domains Protein Structure, Secondary structural biology Wisteria - chemistry x-ray crystallography
Online-Zugang:	Volltext
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