Systematic approaches to identify E3 ligase substrates

Protein ubiquitylation is a widespread post-translational modification, regulating cellular signalling with many outcomes, such as protein degradation, endocytosis, cell cycle progression, DNA repair and transcription. E3 ligases are a critical component of the ubiquitin proteasome system (UPS), det...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical journal 2016-11, Vol.473 (22), p.4083-4101
Hauptverfasser:	Iconomou, Mary, Saunders, Darren N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Proteasome Endopeptidase Complex - metabolism Protein Processing, Post-Translational Proteolysis Proteomics - methods Review Substrate Specificity Ubiquitin - metabolism Ubiquitin-Protein Ligases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!