Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery
Objective The authors hypothesized that genetic association between atrial fibrillation (AF)-associated and PR-associated genetic loci was biologically mediated through slower conduction velocities for some or all of these loci. Design Prospectively collected cohort study. Setting Single tertiary ca...
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| Veröffentlicht in: | Journal of cardiothoracic and vascular anesthesia 2015-06, Vol.29 (3), p.605-610 |
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| creator | Sigurdsson, Martin I., MD, PhD Muehlschlegel, Jochen D., MD, MMSc Fox, Amanda A., MD, MPH Heydarpour, Mahyar, PhD Lichtner, Peter, PhD Meitinger, Thomas, PhD Collard, Charles D., MD Shernan, Stanton K., MD Body, Simon C., MBChB, MPH |
| description | Objective The authors hypothesized that genetic association between atrial fibrillation (AF)-associated and PR-associated genetic loci was biologically mediated through slower conduction velocities for some or all of these loci. Design Prospectively collected cohort study. Setting Single tertiary care university hospital. Participants A total of 1227 Caucasian patients who underwent coronary artery bypass grafting (CABG). Interventions A total of 677 single nucleotide polymorphisms previously associated with ambulatory AF or PR interval were tested for association with postoperative atrial fibrillation (poAF) and preoperative PR interval, maximum PR interval, maximum change in PR interval, and maximum change in PR interval from preoperative PR interval. Measurements and Main Results The incidence of new-onset poAF was 31%. All of the PR interval variables were longer in the poAF cohort. Two variants on 1q21 and 12 on 4q25 were associated with poAF after adjustment for false discovery rate (FDR), but no variants were associated with PR interval variables after adjustment for FDR. Several variants were associated with both poAF and PR interval variables at p |
| doi_str_mv | 10.1053/j.jvca.2014.10.028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5103707</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1053077014005369</els_id><sourcerecordid>1683573261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-9271eabac3ab90b810001786e46e6817d4a0cfdd4e651e291b192253d28d52853</originalsourceid><addsrcrecordid>eNp9Uk1v1DAQjRCIlsIf4IB85JKt7cRxIqFKqxUtlSqBKB83LMee3U7I2q3tLNp_j6NtK-DAyaN5b958PBfFa0YXjIrqdFgMO6MXnLI6JxaUt0-KYyYqXrY1509znFkllZIeFS9iHChlTAj5vDjiDaUdb-Vx8eMCHCQ05JsOqF2KZBmjN6gTWPId0w1ZpgyM5Bz7gOOoE3pHtLPk02dy6RKE3Qz6cfS_0G3ISgeL2pDrKWwg7F8Wz9Z6jPDq_j0pvp6__7L6UF59vLhcLa9KIxhNZcclA91rU-m-o33LaJ5Vtg3UDTQtk7bW1KytraERDHjHetZxLirLWyt4K6qT4uygezv1W7AGXAp6VLcBtzrsldeo_kYc3qiN36ncvpJUZoG39wLB300Qk9piNJAXduCnqFjTVkJWvGGZyg9UE3yMAdaPbRhV88nVoGZj1GzMnMvG5KI3fw74WPLgRCa8OxAgn2mHEFQ0CM6AxQAmKevx__pn_5SbER0aPf6EPcTBT8FlAxRTkSuqrmed-Wewmuao6arfGg20jg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1683573261</pqid></control><display><type>article</type><title>Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Sigurdsson, Martin I., MD, PhD ; Muehlschlegel, Jochen D., MD, MMSc ; Fox, Amanda A., MD, MPH ; Heydarpour, Mahyar, PhD ; Lichtner, Peter, PhD ; Meitinger, Thomas, PhD ; Collard, Charles D., MD ; Shernan, Stanton K., MD ; Body, Simon C., MBChB, MPH</creator><creatorcontrib>Sigurdsson, Martin I., MD, PhD ; Muehlschlegel, Jochen D., MD, MMSc ; Fox, Amanda A., MD, MPH ; Heydarpour, Mahyar, PhD ; Lichtner, Peter, PhD ; Meitinger, Thomas, PhD ; Collard, Charles D., MD ; Shernan, Stanton K., MD ; Body, Simon C., MBChB, MPH</creatorcontrib><description>Objective The authors hypothesized that genetic association between atrial fibrillation (AF)-associated and PR-associated genetic loci was biologically mediated through slower conduction velocities for some or all of these loci. Design Prospectively collected cohort study. Setting Single tertiary care university hospital. Participants A total of 1227 Caucasian patients who underwent coronary artery bypass grafting (CABG). Interventions A total of 677 single nucleotide polymorphisms previously associated with ambulatory AF or PR interval were tested for association with postoperative atrial fibrillation (poAF) and preoperative PR interval, maximum PR interval, maximum change in PR interval, and maximum change in PR interval from preoperative PR interval. Measurements and Main Results The incidence of new-onset poAF was 31%. All of the PR interval variables were longer in the poAF cohort. Two variants on 1q21 and 12 on 4q25 were associated with poAF after adjustment for false discovery rate (FDR), but no variants were associated with PR interval variables after adjustment for FDR. Several variants were associated with both poAF and PR interval variables at p<0.05, but none of them remained significant after adjusting for FDR. Conclusion It was found that patients with poAF have significantly longer PR interval. Genetic variants in both the 1q21 and 4q25 regions associate with poAF after CABG surgery, but the authors were unable to find association between these variants and PR interval after adjusting for FDR.</description><identifier>ISSN: 1053-0770</identifier><identifier>EISSN: 1532-8422</identifier><identifier>DOI: 10.1053/j.jvca.2014.10.028</identifier><identifier>PMID: 26009287</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>1q21 ; 4q25 ; Aged ; Aged, 80 and over ; Anesthesia & Perioperative Care ; atrial fibrillation ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - etiology ; Atrial Fibrillation - genetics ; cardiac surgery ; Cardiac Surgical Procedures - adverse effects ; Cohort Studies ; Critical Care ; Electrocardiography - methods ; Female ; Genetic Variation - genetics ; genomics ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide - genetics ; Postoperative Complications - diagnosis ; Postoperative Complications - etiology ; Postoperative Complications - genetics ; PR interval ; Prospective Studies</subject><ispartof>Journal of cardiothoracic and vascular anesthesia, 2015-06, Vol.29 (3), p.605-610</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-9271eabac3ab90b810001786e46e6817d4a0cfdd4e651e291b192253d28d52853</citedby><cites>FETCH-LOGICAL-c510t-9271eabac3ab90b810001786e46e6817d4a0cfdd4e651e291b192253d28d52853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/j.jvca.2014.10.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26009287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sigurdsson, Martin I., MD, PhD</creatorcontrib><creatorcontrib>Muehlschlegel, Jochen D., MD, MMSc</creatorcontrib><creatorcontrib>Fox, Amanda A., MD, MPH</creatorcontrib><creatorcontrib>Heydarpour, Mahyar, PhD</creatorcontrib><creatorcontrib>Lichtner, Peter, PhD</creatorcontrib><creatorcontrib>Meitinger, Thomas, PhD</creatorcontrib><creatorcontrib>Collard, Charles D., MD</creatorcontrib><creatorcontrib>Shernan, Stanton K., MD</creatorcontrib><creatorcontrib>Body, Simon C., MBChB, MPH</creatorcontrib><title>Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery</title><title>Journal of cardiothoracic and vascular anesthesia</title><addtitle>J Cardiothorac Vasc Anesth</addtitle><description>Objective The authors hypothesized that genetic association between atrial fibrillation (AF)-associated and PR-associated genetic loci was biologically mediated through slower conduction velocities for some or all of these loci. Design Prospectively collected cohort study. Setting Single tertiary care university hospital. Participants A total of 1227 Caucasian patients who underwent coronary artery bypass grafting (CABG). Interventions A total of 677 single nucleotide polymorphisms previously associated with ambulatory AF or PR interval were tested for association with postoperative atrial fibrillation (poAF) and preoperative PR interval, maximum PR interval, maximum change in PR interval, and maximum change in PR interval from preoperative PR interval. Measurements and Main Results The incidence of new-onset poAF was 31%. All of the PR interval variables were longer in the poAF cohort. Two variants on 1q21 and 12 on 4q25 were associated with poAF after adjustment for false discovery rate (FDR), but no variants were associated with PR interval variables after adjustment for FDR. Several variants were associated with both poAF and PR interval variables at p<0.05, but none of them remained significant after adjusting for FDR. Conclusion It was found that patients with poAF have significantly longer PR interval. Genetic variants in both the 1q21 and 4q25 regions associate with poAF after CABG surgery, but the authors were unable to find association between these variants and PR interval after adjusting for FDR.</description><subject>1q21</subject><subject>4q25</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia & Perioperative Care</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - genetics</subject><subject>cardiac surgery</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cohort Studies</subject><subject>Critical Care</subject><subject>Electrocardiography - methods</subject><subject>Female</subject><subject>Genetic Variation - genetics</subject><subject>genomics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - genetics</subject><subject>PR interval</subject><subject>Prospective Studies</subject><issn>1053-0770</issn><issn>1532-8422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk1v1DAQjRCIlsIf4IB85JKt7cRxIqFKqxUtlSqBKB83LMee3U7I2q3tLNp_j6NtK-DAyaN5b958PBfFa0YXjIrqdFgMO6MXnLI6JxaUt0-KYyYqXrY1509znFkllZIeFS9iHChlTAj5vDjiDaUdb-Vx8eMCHCQ05JsOqF2KZBmjN6gTWPId0w1ZpgyM5Bz7gOOoE3pHtLPk02dy6RKE3Qz6cfS_0G3ISgeL2pDrKWwg7F8Wz9Z6jPDq_j0pvp6__7L6UF59vLhcLa9KIxhNZcclA91rU-m-o33LaJ5Vtg3UDTQtk7bW1KytraERDHjHetZxLirLWyt4K6qT4uygezv1W7AGXAp6VLcBtzrsldeo_kYc3qiN36ncvpJUZoG39wLB300Qk9piNJAXduCnqFjTVkJWvGGZyg9UE3yMAdaPbRhV88nVoGZj1GzMnMvG5KI3fw74WPLgRCa8OxAgn2mHEFQ0CM6AxQAmKevx__pn_5SbER0aPf6EPcTBT8FlAxRTkSuqrmed-Wewmuao6arfGg20jg</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Sigurdsson, Martin I., MD, PhD</creator><creator>Muehlschlegel, Jochen D., MD, MMSc</creator><creator>Fox, Amanda A., MD, MPH</creator><creator>Heydarpour, Mahyar, PhD</creator><creator>Lichtner, Peter, PhD</creator><creator>Meitinger, Thomas, PhD</creator><creator>Collard, Charles D., MD</creator><creator>Shernan, Stanton K., MD</creator><creator>Body, Simon C., MBChB, MPH</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery</title><author>Sigurdsson, Martin I., MD, PhD ; Muehlschlegel, Jochen D., MD, MMSc ; Fox, Amanda A., MD, MPH ; Heydarpour, Mahyar, PhD ; Lichtner, Peter, PhD ; Meitinger, Thomas, PhD ; Collard, Charles D., MD ; Shernan, Stanton K., MD ; Body, Simon C., MBChB, MPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-9271eabac3ab90b810001786e46e6817d4a0cfdd4e651e291b192253d28d52853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>1q21</topic><topic>4q25</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia & Perioperative Care</topic><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - genetics</topic><topic>cardiac surgery</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cohort Studies</topic><topic>Critical Care</topic><topic>Electrocardiography - methods</topic><topic>Female</topic><topic>Genetic Variation - genetics</topic><topic>genomics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - genetics</topic><topic>PR interval</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sigurdsson, Martin I., MD, PhD</creatorcontrib><creatorcontrib>Muehlschlegel, Jochen D., MD, MMSc</creatorcontrib><creatorcontrib>Fox, Amanda A., MD, MPH</creatorcontrib><creatorcontrib>Heydarpour, Mahyar, PhD</creatorcontrib><creatorcontrib>Lichtner, Peter, PhD</creatorcontrib><creatorcontrib>Meitinger, Thomas, PhD</creatorcontrib><creatorcontrib>Collard, Charles D., MD</creatorcontrib><creatorcontrib>Shernan, Stanton K., MD</creatorcontrib><creatorcontrib>Body, Simon C., MBChB, MPH</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sigurdsson, Martin I., MD, PhD</au><au>Muehlschlegel, Jochen D., MD, MMSc</au><au>Fox, Amanda A., MD, MPH</au><au>Heydarpour, Mahyar, PhD</au><au>Lichtner, Peter, PhD</au><au>Meitinger, Thomas, PhD</au><au>Collard, Charles D., MD</au><au>Shernan, Stanton K., MD</au><au>Body, Simon C., MBChB, MPH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery</atitle><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle><addtitle>J Cardiothorac Vasc Anesth</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>29</volume><issue>3</issue><spage>605</spage><epage>610</epage><pages>605-610</pages><issn>1053-0770</issn><eissn>1532-8422</eissn><abstract>Objective The authors hypothesized that genetic association between atrial fibrillation (AF)-associated and PR-associated genetic loci was biologically mediated through slower conduction velocities for some or all of these loci. Design Prospectively collected cohort study. Setting Single tertiary care university hospital. Participants A total of 1227 Caucasian patients who underwent coronary artery bypass grafting (CABG). Interventions A total of 677 single nucleotide polymorphisms previously associated with ambulatory AF or PR interval were tested for association with postoperative atrial fibrillation (poAF) and preoperative PR interval, maximum PR interval, maximum change in PR interval, and maximum change in PR interval from preoperative PR interval. Measurements and Main Results The incidence of new-onset poAF was 31%. All of the PR interval variables were longer in the poAF cohort. Two variants on 1q21 and 12 on 4q25 were associated with poAF after adjustment for false discovery rate (FDR), but no variants were associated with PR interval variables after adjustment for FDR. Several variants were associated with both poAF and PR interval variables at p<0.05, but none of them remained significant after adjusting for FDR. Conclusion It was found that patients with poAF have significantly longer PR interval. Genetic variants in both the 1q21 and 4q25 regions associate with poAF after CABG surgery, but the authors were unable to find association between these variants and PR interval after adjusting for FDR.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26009287</pmid><doi>10.1053/j.jvca.2014.10.028</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1q21 4q25 Aged Aged, 80 and over Anesthesia & Perioperative Care atrial fibrillation Atrial Fibrillation - diagnosis Atrial Fibrillation - etiology Atrial Fibrillation - genetics cardiac surgery Cardiac Surgical Procedures - adverse effects Cohort Studies Critical Care Electrocardiography - methods Female Genetic Variation - genetics genomics Humans Male Middle Aged Polymorphism, Single Nucleotide - genetics Postoperative Complications - diagnosis Postoperative Complications - etiology Postoperative Complications - genetics PR interval Prospective Studies |
| title | Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery |
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