Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli
The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current (I ) and the h-current (I ), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean...
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Veröffentlicht in: | Journal of neurophysiology 2016-11, Vol.116 (5), p.2001-2003 |
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creator | Thor, Michael G Morris, Gareth |
description | The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current (I
) and the h-current (I
), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean (J Neurophysiol 114: 2376-2389, 2015) used pharmacological methods to discern the roles of I
and I
at subthreshold voltages during naturalistic stimuli. We discuss these findings in the context of dorsoventral heterogeneity in the hippocampus and suggest further applications of the method. |
doi_str_mv | 10.1152/jn.00031.2016 |
format | Article |
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) and the h-current (I
), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean (J Neurophysiol 114: 2376-2389, 2015) used pharmacological methods to discern the roles of I
and I
at subthreshold voltages during naturalistic stimuli. We discuss these findings in the context of dorsoventral heterogeneity in the hippocampus and suggest further applications of the method.</description><identifier>ISSN: 0022-3077</identifier><identifier>EISSN: 1522-1598</identifier><identifier>DOI: 10.1152/jn.00031.2016</identifier><identifier>PMID: 26912587</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Animals ; CA1 Region, Hippocampal - cytology ; CA1 Region, Hippocampal - physiology ; Humans ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - physiology ; Membrane Potentials - physiology ; Neuro Forum ; Sodium Channels - physiology</subject><ispartof>Journal of neurophysiology, 2016-11, Vol.116 (5), p.2001-2003</ispartof><rights>Copyright © 2016 the American Physiological Society.</rights><rights>Copyright © 2016 the American Physiological Society 2016 American Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-2469-5102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26912587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thor, Michael G</creatorcontrib><creatorcontrib>Morris, Gareth</creatorcontrib><title>Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli</title><title>Journal of neurophysiology</title><addtitle>J Neurophysiol</addtitle><description>The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current (I
) and the h-current (I
), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean (J Neurophysiol 114: 2376-2389, 2015) used pharmacological methods to discern the roles of I
and I
at subthreshold voltages during naturalistic stimuli. We discuss these findings in the context of dorsoventral heterogeneity in the hippocampus and suggest further applications of the method.</description><subject>Animals</subject><subject>CA1 Region, Hippocampal - cytology</subject><subject>CA1 Region, Hippocampal - physiology</subject><subject>Humans</subject><subject>Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - physiology</subject><subject>Membrane Potentials - physiology</subject><subject>Neuro Forum</subject><subject>Sodium Channels - physiology</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtL9DAUhoMoOl6WbiVLNzMmJ23SbgQZPi8guNF1Sdp0GkmTMRfBf2-GT0U3536el3MQOqdkRWkNV69uRQhhdAWE8j20KDVY0rpt9tGCkBIzIsQROo7xtcyJmsAhOgLeUqgbsUBu7V0KMibjNjh4qyP2I36YsHQDTpPGWx2iiUm7hKMfTJ5xn0PYpbJUskpT0HHydsDv3ia5KYAhhx3NyZSDtGXZ9LiYOVtzig5GaaM--_In6OX23_P6fvn4dPewvnlcbgEIXza9GjnUVMlKM8EawWtBtWYNUwMfBFDRtG0F9QgcVMWUqgjoamwq1nM1UsZO0PV_7jarWQ-93h1pu20wswwfnZem-9txZuo2_r2rKQEGUACXX4Dg37KOqZtN7LW10mmfY0cb4JwLBm0Zvfit9SPy_WT2CVEFgQg</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Thor, Michael G</creator><creator>Morris, Gareth</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2469-5102</orcidid></search><sort><creationdate>20161101</creationdate><title>Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli</title><author>Thor, Michael G ; Morris, Gareth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2206-8cbf6251ba4e373876571ee383bd6d7217899425f262b43bb402e4f843c6bf133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>CA1 Region, Hippocampal - cytology</topic><topic>CA1 Region, Hippocampal - physiology</topic><topic>Humans</topic><topic>Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - physiology</topic><topic>Membrane Potentials - physiology</topic><topic>Neuro Forum</topic><topic>Sodium Channels - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thor, Michael G</creatorcontrib><creatorcontrib>Morris, Gareth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thor, Michael G</au><au>Morris, Gareth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>116</volume><issue>5</issue><spage>2001</spage><epage>2003</epage><pages>2001-2003</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><abstract>The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current (I
) and the h-current (I
), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean (J Neurophysiol 114: 2376-2389, 2015) used pharmacological methods to discern the roles of I
and I
at subthreshold voltages during naturalistic stimuli. We discuss these findings in the context of dorsoventral heterogeneity in the hippocampus and suggest further applications of the method.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>26912587</pmid><doi>10.1152/jn.00031.2016</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0003-2469-5102</orcidid><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
subjects | Animals CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - physiology Humans Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - physiology Membrane Potentials - physiology Neuro Forum Sodium Channels - physiology |
title | Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli |
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