Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli

The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current (I ) and the h-current (I ), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean...

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Veröffentlicht in:Journal of neurophysiology 2016-11, Vol.116 (5), p.2001-2003
Hauptverfasser: Thor, Michael G, Morris, Gareth
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container_title Journal of neurophysiology
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creator Thor, Michael G
Morris, Gareth
description The subthreshold activity of hippocampal CA1 pyramidal neurons is regulated by the persistent sodium current (I ) and the h-current (I ), carried by tetrodotoxin-sensitive sodium channels and hyperpolarization-activated cyclic-nucleotide-gated channels, respectively. Recently, Yamada-Hanff and Bean (J Neurophysiol 114: 2376-2389, 2015) used pharmacological methods to discern the roles of I and I at subthreshold voltages during naturalistic stimuli. We discuss these findings in the context of dorsoventral heterogeneity in the hippocampus and suggest further applications of the method.
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subjects Animals
CA1 Region, Hippocampal - cytology
CA1 Region, Hippocampal - physiology
Humans
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - physiology
Membrane Potentials - physiology
Neuro Forum
Sodium Channels - physiology
title Contrasting roles of Ih and the persistent sodium current at subthreshold voltages during naturalistic stimuli
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