Insulin receptor substrate‐1 time‐dependently regulates bone formation by controlling collagen Iα2 expression via miR‐342

ABSTRACT Insulin promotes bone formation via a well‐studied canonical signaling pathway. An adapter in this pathway, insulin‐receptor substrate (IRS)‐1, has been implicated in the diabetic osteopathy provoked by impaired insulin signaling. To further investigate IRS‐1's role in the bone metabol...

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Veröffentlicht in:	The FASEB journal 2016-12, Vol.30 (12), p.4214-4226
Hauptverfasser:	Guo, Yue, Tang, Chen‐Yi, Man, Xiao‐Fei, Tang, Hao‐Neng, Tang, Jun, Wang, Fang, Zhou, Ci‐La, Tan, Shu‐Wen, Feng, Yun‐Zhi, Zhou, Hou‐De
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bone formation Bone Marrow Cells - cytology Cell Differentiation - physiology Cells, Cultured collagen 1a2 Collagen Type I - genetics Collagen Type I - metabolism insulin receptor substrate Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - metabolism Mesenchymal Stromal Cells - cytology Mice, Transgenic MicroRNAs - genetics miR‐342 Osteoblasts - cytology Osteogenesis - physiology Signal Transduction - physiology Time Factors
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