Musulju improves benign prostatic hyperplasia by regulating inflammatory and apoptotic proteins
Alternative medicine is a widely accepted therapeutic approach for the management of various diseases. The Korean medicine, musulju (MSJ), has been traditionally used to improve vital energy in men with reduced physical strength and a weakened urinary system. The present study determined the mechani...
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| Veröffentlicht in: | Molecular medicine reports 2016-11, Vol.14 (5), p.4692-4698 |
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| creator | Ju, Jae-Yun Chung, Kyung-Sook Cheon, Se-Yun An, Hyo-Jin |
| description | Alternative medicine is a widely accepted therapeutic approach for the management of various diseases. The Korean medicine, musulju (MSJ), has been traditionally used to improve vital energy in men with reduced physical strength and a weakened urinary system. The present study determined the mechanisms underlying the protective effect of MSJ against benign prostatic hyperplasia (BPH), a common disorder in elderly men that involves inflammation-mediated imbalance between cell proliferation and death. MSJ treatment was demonstrated to decrease prostate weight, cell proliferation, and the protein expression of proliferating cell nuclear antigen in a rat model of BPH. In addition, MSJ markedly reduced serum testosterone levels, 5α-reductase2 mRNA expression and BPH-associated upregulation of inflammatory proteins, inducible nitric oxide synthase and cyclooxygenase 2. Furthermore, MSJ induced apoptosis by regulating B-cell lymphoma (Bcl)-2 protein expression and the Bcl-2:Bax ratio, leading to caspase 3 activation. Taken together, MSJ demonstrated antiproliferative effects in BPH model rats by regulating the expression levels of proteins involved in inflammation and apoptosis. The effects of MSJ may be attributed to its alternative therapeutic properties. |
| doi_str_mv | 10.3892/mmr.2016.5839 |
| format | Article |
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The Korean medicine, musulju (MSJ), has been traditionally used to improve vital energy in men with reduced physical strength and a weakened urinary system. The present study determined the mechanisms underlying the protective effect of MSJ against benign prostatic hyperplasia (BPH), a common disorder in elderly men that involves inflammation-mediated imbalance between cell proliferation and death. MSJ treatment was demonstrated to decrease prostate weight, cell proliferation, and the protein expression of proliferating cell nuclear antigen in a rat model of BPH. In addition, MSJ markedly reduced serum testosterone levels, 5α-reductase2 mRNA expression and BPH-associated upregulation of inflammatory proteins, inducible nitric oxide synthase and cyclooxygenase 2. Furthermore, MSJ induced apoptosis by regulating B-cell lymphoma (Bcl)-2 protein expression and the Bcl-2:Bax ratio, leading to caspase 3 activation. Taken together, MSJ demonstrated antiproliferative effects in BPH model rats by regulating the expression levels of proteins involved in inflammation and apoptosis. The effects of MSJ may be attributed to its alternative therapeutic properties.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2016.5839</identifier><identifier>PMID: 27748836</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism ; Alternative medicine ; Androgens ; Animals ; Apoptosis ; Apoptosis - drug effects ; B-cell lymphoma ; BAX protein ; Bcl-2 protein ; Benign ; benign prostatic hyperplasia ; Caspase ; Caspase-3 ; Cell death ; Cell proliferation ; Cell Proliferation - drug effects ; Cyclooxygenase-2 ; Gene expression ; Genital diseases ; Geriatrics ; Health aspects ; Hyperplasia ; Hypertrophy ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Inflammation - pathology ; Inflammation Mediators - metabolism ; Lymphocytes B ; Male ; Medicinal plants ; Medicine, Korean Traditional ; Methods ; musulju ; Nitric oxide ; Nitric-oxide synthase ; Organ Size - drug effects ; Plant Extracts - pharmacology ; Proliferating cell nuclear antigen ; Prostate ; Prostatic Hyperplasia - drug therapy ; Prostatic Hyperplasia - metabolism ; Prostatic Hyperplasia - pathology ; Rats ; Rodents ; Testosterone ; Testosterone - blood ; Testosterone - metabolism</subject><ispartof>Molecular medicine reports, 2016-11, Vol.14 (5), p.4692-4698</ispartof><rights>Copyright: © Ju et al.</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright: © Ju et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-82a136e0240745aec2c1b361ce53af41a1684ef71f9c97cfe8a4ef0397f0e1cb3</citedby><cites>FETCH-LOGICAL-c514t-82a136e0240745aec2c1b361ce53af41a1684ef71f9c97cfe8a4ef0397f0e1cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,5555,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27748836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ju, Jae-Yun</creatorcontrib><creatorcontrib>Chung, Kyung-Sook</creatorcontrib><creatorcontrib>Cheon, Se-Yun</creatorcontrib><creatorcontrib>An, Hyo-Jin</creatorcontrib><title>Musulju improves benign prostatic hyperplasia by regulating inflammatory and apoptotic proteins</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Alternative medicine is a widely accepted therapeutic approach for the management of various diseases. The Korean medicine, musulju (MSJ), has been traditionally used to improve vital energy in men with reduced physical strength and a weakened urinary system. The present study determined the mechanisms underlying the protective effect of MSJ against benign prostatic hyperplasia (BPH), a common disorder in elderly men that involves inflammation-mediated imbalance between cell proliferation and death. MSJ treatment was demonstrated to decrease prostate weight, cell proliferation, and the protein expression of proliferating cell nuclear antigen in a rat model of BPH. In addition, MSJ markedly reduced serum testosterone levels, 5α-reductase2 mRNA expression and BPH-associated upregulation of inflammatory proteins, inducible nitric oxide synthase and cyclooxygenase 2. Furthermore, MSJ induced apoptosis by regulating B-cell lymphoma (Bcl)-2 protein expression and the Bcl-2:Bax ratio, leading to caspase 3 activation. Taken together, MSJ demonstrated antiproliferative effects in BPH model rats by regulating the expression levels of proteins involved in inflammation and apoptosis. The effects of MSJ may be attributed to its alternative therapeutic properties.</description><subject>3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism</subject><subject>Alternative medicine</subject><subject>Androgens</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>B-cell lymphoma</subject><subject>BAX protein</subject><subject>Bcl-2 protein</subject><subject>Benign</subject><subject>benign prostatic hyperplasia</subject><subject>Caspase</subject><subject>Caspase-3</subject><subject>Cell death</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cyclooxygenase-2</subject><subject>Gene expression</subject><subject>Genital diseases</subject><subject>Geriatrics</subject><subject>Health aspects</subject><subject>Hyperplasia</subject><subject>Hypertrophy</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Inflammation Mediators - metabolism</subject><subject>Lymphocytes B</subject><subject>Male</subject><subject>Medicinal plants</subject><subject>Medicine, Korean Traditional</subject><subject>Methods</subject><subject>musulju</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Organ Size - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Proliferating cell nuclear antigen</subject><subject>Prostate</subject><subject>Prostatic Hyperplasia - drug therapy</subject><subject>Prostatic Hyperplasia - metabolism</subject><subject>Prostatic Hyperplasia - pathology</subject><subject>Rats</subject><subject>Rodents</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Testosterone - metabolism</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkk1v1DAQhiMEoqVw5IoicYBLFo_txPEFqar4koq4wNlyvJOtV4kd7KTS_nsm2mWhCPlgj_3Ma83MWxQvgW1Eq_m7cUwbzqDZ1K3Qj4pLUBoqwZh8fDpzrdVF8SznPWNNzWv9tLjgSsm2Fc1lYb4ueRn2S-nHKcV7zGWHwe9CSVGe7exdeXeYME2Dzd6W3aFMuFsGegi70od-sONo55gOpQ3b0k5xmuOaROkz-pCfF096O2R8cdqvih8fP3y_-Vzdfvv05eb6tnI1yLlquQXRIOOSKVlbdNxBJxpwWAvbS7DQtBJ7Bb12WrkeW0shE1r1DMF14qp4f9Sdlm7ErcMwJzuYKfnRpoOJ1puHL8HfmV28NzUwziSQwNuTQIo_F8yzGX12OAw2YFyygVbUUspGKEJf_4Pu45IClWdAC640tZz_oXZ2QEOtivSvW0XNtVRctxpg1dr8h6K1xdG7GLD3dP8goTomOBpQTtifawRmVkcYcoRZHWFWRxD_6u_GnOnfFiDgzRHIE43Qb2M-M6RUgaxYXcmGKvoFNnvAdw</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Ju, Jae-Yun</creator><creator>Chung, Kyung-Sook</creator><creator>Cheon, Se-Yun</creator><creator>An, Hyo-Jin</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161101</creationdate><title>Musulju improves benign prostatic hyperplasia by regulating inflammatory and apoptotic proteins</title><author>Ju, Jae-Yun ; Chung, Kyung-Sook ; Cheon, Se-Yun ; An, Hyo-Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-82a136e0240745aec2c1b361ce53af41a1684ef71f9c97cfe8a4ef0397f0e1cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism</topic><topic>Alternative medicine</topic><topic>Androgens</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>B-cell lymphoma</topic><topic>BAX protein</topic><topic>Bcl-2 protein</topic><topic>Benign</topic><topic>benign prostatic hyperplasia</topic><topic>Caspase</topic><topic>Caspase-3</topic><topic>Cell death</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cyclooxygenase-2</topic><topic>Gene expression</topic><topic>Genital diseases</topic><topic>Geriatrics</topic><topic>Health aspects</topic><topic>Hyperplasia</topic><topic>Hypertrophy</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Inflammation Mediators - metabolism</topic><topic>Lymphocytes B</topic><topic>Male</topic><topic>Medicinal plants</topic><topic>Medicine, Korean Traditional</topic><topic>Methods</topic><topic>musulju</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Organ Size - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Proliferating cell nuclear antigen</topic><topic>Prostate</topic><topic>Prostatic Hyperplasia - drug therapy</topic><topic>Prostatic Hyperplasia - metabolism</topic><topic>Prostatic Hyperplasia - pathology</topic><topic>Rats</topic><topic>Rodents</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>Testosterone - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ju, Jae-Yun</creatorcontrib><creatorcontrib>Chung, Kyung-Sook</creatorcontrib><creatorcontrib>Cheon, Se-Yun</creatorcontrib><creatorcontrib>An, Hyo-Jin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ju, Jae-Yun</au><au>Chung, Kyung-Sook</au><au>Cheon, Se-Yun</au><au>An, Hyo-Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Musulju improves benign prostatic hyperplasia by regulating inflammatory and apoptotic proteins</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>14</volume><issue>5</issue><spage>4692</spage><epage>4698</epage><pages>4692-4698</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Alternative medicine is a widely accepted therapeutic approach for the management of various diseases. The Korean medicine, musulju (MSJ), has been traditionally used to improve vital energy in men with reduced physical strength and a weakened urinary system. The present study determined the mechanisms underlying the protective effect of MSJ against benign prostatic hyperplasia (BPH), a common disorder in elderly men that involves inflammation-mediated imbalance between cell proliferation and death. MSJ treatment was demonstrated to decrease prostate weight, cell proliferation, and the protein expression of proliferating cell nuclear antigen in a rat model of BPH. In addition, MSJ markedly reduced serum testosterone levels, 5α-reductase2 mRNA expression and BPH-associated upregulation of inflammatory proteins, inducible nitric oxide synthase and cyclooxygenase 2. Furthermore, MSJ induced apoptosis by regulating B-cell lymphoma (Bcl)-2 protein expression and the Bcl-2:Bax ratio, leading to caspase 3 activation. Taken together, MSJ demonstrated antiproliferative effects in BPH model rats by regulating the expression levels of proteins involved in inflammation and apoptosis. The effects of MSJ may be attributed to its alternative therapeutic properties.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>27748836</pmid><doi>10.3892/mmr.2016.5839</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism Alternative medicine Androgens Animals Apoptosis Apoptosis - drug effects B-cell lymphoma BAX protein Bcl-2 protein Benign benign prostatic hyperplasia Caspase Caspase-3 Cell death Cell proliferation Cell Proliferation - drug effects Cyclooxygenase-2 Gene expression Genital diseases Geriatrics Health aspects Hyperplasia Hypertrophy Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Lymphocytes B Male Medicinal plants Medicine, Korean Traditional Methods musulju Nitric oxide Nitric-oxide synthase Organ Size - drug effects Plant Extracts - pharmacology Proliferating cell nuclear antigen Prostate Prostatic Hyperplasia - drug therapy Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Rats Rodents Testosterone Testosterone - blood Testosterone - metabolism |
| title | Musulju improves benign prostatic hyperplasia by regulating inflammatory and apoptotic proteins |
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