Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules

The involvement of tissue ischemia in obesity-induced kidney injury remains to be elucidated. Compared with low fat diet (LFD)-mice, high fat diet (HFD)-fed mice became obese with tubular enlargement, glomerulomegaly and peritubular capillary rarefaction, and exhibited both tubular and glomerular da...

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Veröffentlicht in:	Scientific reports 2016-11, Vol.6 (1), p.36533-36533, Article 36533
Hauptverfasser:	Futatsugi, Koji, Tokuyama, Hirobumi, Shibata, Shinsuke, Naitoh, Makiko, Kanda, Takeshi, Minakuchi, Hitoshi, Yamaguchi, Shintaro, Hayashi, Koichi, Minamishima, Yoji Andrew, Yanagita, Motoko, Wakino, Shu, Itoh, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/51 14/63 42/41 631/337/572 692/4022/1585/104 Capillaries Fatty acids High fat diet Humanities and Social Sciences Hydroxylase Hypoxia Inactivation Ischemia Kidneys Low fat diet multidisciplinary Obesity Proximal tubules Rodents Science Tamoxifen
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