2-Aminobutyric acid modulates glutathione homeostasis in the myocardium

A previous report showed that the consumption of glutathione through oxidative stress activates the glutathione synthetic pathway, which is accompanied by production of ophthalmic acid from 2-aminobutyric acid (2-AB). We conducted a comprehensive quantification of serum metabolites using gas chromat...

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Veröffentlicht in:	Scientific reports 2016-11, Vol.6 (1), p.36749-36749, Article 36749
Hauptverfasser:	Irino, Yasuhiro, Toh, Ryuji, Nagao, Manabu, Mori, Takeshige, Honjo, Tomoyuki, Shinohara, Masakazu, Tsuda, Shigeyasu, Nakajima, Hideto, Satomi-Kobayashi, Seimi, Shinke, Toshiro, Tanaka, Hidekazu, Ishida, Tatsuro, Miyata, Okiko, Hirata, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/320 631/80/304 82/80 Acids Biosynthesis Cardiomyopathy Cysteine Doxorubicin Gas chromatography Glutathione Homeostasis Humanities and Social Sciences Mass spectrometry Mass spectroscopy Metabolites multidisciplinary Myocardium Oral administration Oxidative stress Reactive oxygen species Rodents Science
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