Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China
Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses wer...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2016-11, Vol.6 (1), p.36332-36332, Article 36332 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 36332 |
|---|---|
| container_issue | 1 |
| container_start_page | 36332 |
| container_title | Scientific reports |
| container_volume | 6 |
| creator | Hu, Pan Zhao, Liming Zhang, Huilin Yu, Xiuchun Wang, Zhen Ye, Zhaoming Wu, Sujia Guo, Shibing Zhang, Guochuan Wang, Jinghua Ning, Xianjia Hu, Yongcheng Zhang, Yingze |
| description | Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23.4%, but was higher in patients aged 20–39 years (28.5%; P = 0.039). The local recurrence rate was the highest in patients treated with intralesional curettage (53.4%), and the lowest in those treated with resection (4.9%). We found a higher risk of tumor recurrence in the proximal fibula compared to the distal femur (hazard ratio: 28.52, 95% confidence interval: 5.88–138.39; P |
| doi_str_mv | 10.1038/srep36332 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5101496</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1899333123</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-8fb1b02a0c032d0724e4d286da00efd3653ab04a210bacb8db2c68c0b784e0393</originalsourceid><addsrcrecordid>eNplkV1rFDEUhoNYbKm98A9IwBsV1iY52dmMF4Wy2CqtKGu9DpnMmW7qbLLmo1D886ZuXbaamwTeJ-_5eAl5wdk7zkAdp4hraADEE3IgmJxOBAjxdOe9T45SumH1TEUrefuM7IuZEjNQ8oD8WqAtMaK3SBcmY6LG93Th0g96ZmwOMdEhRPo1upWJd_TcGZ_pHMeRXpXVvWpiKPVHXiK98Ijv6Sn9XMbsLPocqyfmGNIabXa3SL_l0t9R5-l86bx5TvYGMyY8ergPyfezD1fzj5PLL-ef5qeXEytB5YkaOt4xYZhlIHo2ExJlL1TTG8Zw6KGZgumYNIKzzthO9Z2wjbKsmymJDFo4JCcb33XpVtj_6cyMer2ZSQfj9GPFu6W-Drd6yhmXbVMNXj8YxPCzYMp65ZKtSzAeQ0maK2h53a1gFX31D3oTSvR1vEq1LQBwAZV6s6FsXU4NcNg2w5m-T1VvU63sy93ut-TfDCvwdgOkKvlrjDsl_3P7DXpjrK0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1899333123</pqid></control><display><type>article</type><title>Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Hu, Pan ; Zhao, Liming ; Zhang, Huilin ; Yu, Xiuchun ; Wang, Zhen ; Ye, Zhaoming ; Wu, Sujia ; Guo, Shibing ; Zhang, Guochuan ; Wang, Jinghua ; Ning, Xianjia ; Hu, Yongcheng ; Zhang, Yingze</creator><creatorcontrib>Hu, Pan ; Zhao, Liming ; Zhang, Huilin ; Yu, Xiuchun ; Wang, Zhen ; Ye, Zhaoming ; Wu, Sujia ; Guo, Shibing ; Zhang, Guochuan ; Wang, Jinghua ; Ning, Xianjia ; Hu, Yongcheng ; Zhang, Yingze</creatorcontrib><description>Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23.4%, but was higher in patients aged 20–39 years (28.5%; P = 0.039). The local recurrence rate was the highest in patients treated with intralesional curettage (53.4%), and the lowest in those treated with resection (4.9%). We found a higher risk of tumor recurrence in the proximal fibula compared to the distal femur (hazard ratio: 28.52, 95% confidence interval: 5.88–138.39; P < 0.0001), and in patients treated with curettage compared to those treated with resection (hazard ratio: 12.07, 95% confidence interval: 4.99–29.18; P < 0.0001). Thus, the tumor location must be considered when selecting the optimal surgical treatment approach to reduce the risk of local recurrence and preserve joint function, especially in young patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep36332</identifier><identifier>PMID: 27827384</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/1344 ; 692/4028/546 ; Adolescent ; Adult ; Age Distribution ; Aged ; Bone Neoplasms - epidemiology ; Bone Neoplasms - pathology ; Bone Neoplasms - surgery ; Bone tumors ; China ; Confidence intervals ; Curettage ; Female ; Femur ; Fibula ; Fibula - pathology ; Fibula - surgery ; Giant Cell Tumor of Bone - epidemiology ; Giant Cell Tumor of Bone - pathology ; Giant Cell Tumor of Bone - surgery ; Health risk assessment ; Humanities and Social Sciences ; Humans ; Knee ; Knee - pathology ; Knee - surgery ; Male ; Middle Aged ; multidisciplinary ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - surgery ; Retrospective Studies ; Risk Factors ; Science ; Tumors ; Young Adult</subject><ispartof>Scientific reports, 2016-11, Vol.6 (1), p.36332-36332, Article 36332</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Nov 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-8fb1b02a0c032d0724e4d286da00efd3653ab04a210bacb8db2c68c0b784e0393</citedby><cites>FETCH-LOGICAL-c438t-8fb1b02a0c032d0724e4d286da00efd3653ab04a210bacb8db2c68c0b784e0393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101496/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101496/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27827384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Pan</creatorcontrib><creatorcontrib>Zhao, Liming</creatorcontrib><creatorcontrib>Zhang, Huilin</creatorcontrib><creatorcontrib>Yu, Xiuchun</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>Ye, Zhaoming</creatorcontrib><creatorcontrib>Wu, Sujia</creatorcontrib><creatorcontrib>Guo, Shibing</creatorcontrib><creatorcontrib>Zhang, Guochuan</creatorcontrib><creatorcontrib>Wang, Jinghua</creatorcontrib><creatorcontrib>Ning, Xianjia</creatorcontrib><creatorcontrib>Hu, Yongcheng</creatorcontrib><creatorcontrib>Zhang, Yingze</creatorcontrib><title>Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23.4%, but was higher in patients aged 20–39 years (28.5%; P = 0.039). The local recurrence rate was the highest in patients treated with intralesional curettage (53.4%), and the lowest in those treated with resection (4.9%). We found a higher risk of tumor recurrence in the proximal fibula compared to the distal femur (hazard ratio: 28.52, 95% confidence interval: 5.88–138.39; P < 0.0001), and in patients treated with curettage compared to those treated with resection (hazard ratio: 12.07, 95% confidence interval: 4.99–29.18; P < 0.0001). Thus, the tumor location must be considered when selecting the optimal surgical treatment approach to reduce the risk of local recurrence and preserve joint function, especially in young patients.</description><subject>631/67/1344</subject><subject>692/4028/546</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Bone Neoplasms - epidemiology</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Neoplasms - surgery</subject><subject>Bone tumors</subject><subject>China</subject><subject>Confidence intervals</subject><subject>Curettage</subject><subject>Female</subject><subject>Femur</subject><subject>Fibula</subject><subject>Fibula - pathology</subject><subject>Fibula - surgery</subject><subject>Giant Cell Tumor of Bone - epidemiology</subject><subject>Giant Cell Tumor of Bone - pathology</subject><subject>Giant Cell Tumor of Bone - surgery</subject><subject>Health risk assessment</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Knee</subject><subject>Knee - pathology</subject><subject>Knee - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkV1rFDEUhoNYbKm98A9IwBsV1iY52dmMF4Wy2CqtKGu9DpnMmW7qbLLmo1D886ZuXbaamwTeJ-_5eAl5wdk7zkAdp4hraADEE3IgmJxOBAjxdOe9T45SumH1TEUrefuM7IuZEjNQ8oD8WqAtMaK3SBcmY6LG93Th0g96ZmwOMdEhRPo1upWJd_TcGZ_pHMeRXpXVvWpiKPVHXiK98Ijv6Sn9XMbsLPocqyfmGNIabXa3SL_l0t9R5-l86bx5TvYGMyY8ergPyfezD1fzj5PLL-ef5qeXEytB5YkaOt4xYZhlIHo2ExJlL1TTG8Zw6KGZgumYNIKzzthO9Z2wjbKsmymJDFo4JCcb33XpVtj_6cyMer2ZSQfj9GPFu6W-Drd6yhmXbVMNXj8YxPCzYMp65ZKtSzAeQ0maK2h53a1gFX31D3oTSvR1vEq1LQBwAZV6s6FsXU4NcNg2w5m-T1VvU63sy93ut-TfDCvwdgOkKvlrjDsl_3P7DXpjrK0</recordid><startdate>20161109</startdate><enddate>20161109</enddate><creator>Hu, Pan</creator><creator>Zhao, Liming</creator><creator>Zhang, Huilin</creator><creator>Yu, Xiuchun</creator><creator>Wang, Zhen</creator><creator>Ye, Zhaoming</creator><creator>Wu, Sujia</creator><creator>Guo, Shibing</creator><creator>Zhang, Guochuan</creator><creator>Wang, Jinghua</creator><creator>Ning, Xianjia</creator><creator>Hu, Yongcheng</creator><creator>Zhang, Yingze</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161109</creationdate><title>Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China</title><author>Hu, Pan ; Zhao, Liming ; Zhang, Huilin ; Yu, Xiuchun ; Wang, Zhen ; Ye, Zhaoming ; Wu, Sujia ; Guo, Shibing ; Zhang, Guochuan ; Wang, Jinghua ; Ning, Xianjia ; Hu, Yongcheng ; Zhang, Yingze</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-8fb1b02a0c032d0724e4d286da00efd3653ab04a210bacb8db2c68c0b784e0393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/67/1344</topic><topic>692/4028/546</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Bone Neoplasms - epidemiology</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Neoplasms - surgery</topic><topic>Bone tumors</topic><topic>China</topic><topic>Confidence intervals</topic><topic>Curettage</topic><topic>Female</topic><topic>Femur</topic><topic>Fibula</topic><topic>Fibula - pathology</topic><topic>Fibula - surgery</topic><topic>Giant Cell Tumor of Bone - epidemiology</topic><topic>Giant Cell Tumor of Bone - pathology</topic><topic>Giant Cell Tumor of Bone - surgery</topic><topic>Health risk assessment</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Knee</topic><topic>Knee - pathology</topic><topic>Knee - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Pan</creatorcontrib><creatorcontrib>Zhao, Liming</creatorcontrib><creatorcontrib>Zhang, Huilin</creatorcontrib><creatorcontrib>Yu, Xiuchun</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>Ye, Zhaoming</creatorcontrib><creatorcontrib>Wu, Sujia</creatorcontrib><creatorcontrib>Guo, Shibing</creatorcontrib><creatorcontrib>Zhang, Guochuan</creatorcontrib><creatorcontrib>Wang, Jinghua</creatorcontrib><creatorcontrib>Ning, Xianjia</creatorcontrib><creatorcontrib>Hu, Yongcheng</creatorcontrib><creatorcontrib>Zhang, Yingze</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Pan</au><au>Zhao, Liming</au><au>Zhang, Huilin</au><au>Yu, Xiuchun</au><au>Wang, Zhen</au><au>Ye, Zhaoming</au><au>Wu, Sujia</au><au>Guo, Shibing</au><au>Zhang, Guochuan</au><au>Wang, Jinghua</au><au>Ning, Xianjia</au><au>Hu, Yongcheng</au><au>Zhang, Yingze</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-11-09</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>36332</spage><epage>36332</epage><pages>36332-36332</pages><artnum>36332</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Giant cell tumors of the bone (GCTBs) are commonly diagnosed in Asian populations, usually around the knee. Herein, we aimed to determine the clinical characteristics, local recurrence rates, and relevant risk factors of primary GCTB around the knee. Univariate and multivariate survival analyses were used to identify the risk factors for local recurrence. Four hundred ten patients with primary GCTB around the knee, treated between March 2000 and June 2014, were recruited from 7 institutions in China. The overall local recurrence rate was 23.4%, but was higher in patients aged 20–39 years (28.5%; P = 0.039). The local recurrence rate was the highest in patients treated with intralesional curettage (53.4%), and the lowest in those treated with resection (4.9%). We found a higher risk of tumor recurrence in the proximal fibula compared to the distal femur (hazard ratio: 28.52, 95% confidence interval: 5.88–138.39; P < 0.0001), and in patients treated with curettage compared to those treated with resection (hazard ratio: 12.07, 95% confidence interval: 4.99–29.18; P < 0.0001). Thus, the tumor location must be considered when selecting the optimal surgical treatment approach to reduce the risk of local recurrence and preserve joint function, especially in young patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27827384</pmid><doi>10.1038/srep36332</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2016-11, Vol.6 (1), p.36332-36332, Article 36332 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5101496 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 631/67/1344 692/4028/546 Adolescent Adult Age Distribution Aged Bone Neoplasms - epidemiology Bone Neoplasms - pathology Bone Neoplasms - surgery Bone tumors China Confidence intervals Curettage Female Femur Fibula Fibula - pathology Fibula - surgery Giant Cell Tumor of Bone - epidemiology Giant Cell Tumor of Bone - pathology Giant Cell Tumor of Bone - surgery Health risk assessment Humanities and Social Sciences Humans Knee Knee - pathology Knee - surgery Male Middle Aged multidisciplinary Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - surgery Retrospective Studies Risk Factors Science Tumors Young Adult |
| title | Recurrence Rates and Risk Factors for Primary Giant Cell Tumors around the Knee: A Multicentre Retrospective Study in China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T13%3A36%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recurrence%20Rates%20and%20Risk%20Factors%20for%20Primary%20Giant%20Cell%20Tumors%20around%20the%20Knee:%20A%20Multicentre%20Retrospective%20Study%20in%20China&rft.jtitle=Scientific%20reports&rft.au=Hu,%20Pan&rft.date=2016-11-09&rft.volume=6&rft.issue=1&rft.spage=36332&rft.epage=36332&rft.pages=36332-36332&rft.artnum=36332&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep36332&rft_dat=%3Cproquest_pubme%3E1899333123%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1899333123&rft_id=info:pmid/27827384&rfr_iscdi=true |