Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway

The first step of the hierarchically organized Arg/N-end rule pathway of protein degradation is deamidation of the N-terminal glutamine and asparagine residues of substrate proteins to glutamate and aspartate, respectively. These reactions are catalyzed by the N-terminal amidase (Nt-amidase) Nta1 in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-11, Vol.113 (44), p.12438-12443
Hauptverfasser:	Kim, Min Kyung, Oh, Sun Joo, Lee, Byung-Gil, Song, Hyun Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Hydrogen bonds Mutagenesis Peptides Proteins Saccharomyces cerevisiae Yeast
Online-Zugang:	Volltext
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