Antineoplastic-related cardiotoxicity, morphofunctional aspects in a murine model: contribution of the new tool 2D-speckle tracking

Considering that global left ventricular systolic radial strain is a sensitive technique for the early detection of left ventricular dysfunction due to antineoplastics and the analysis of segmental myocardial contractility, we evaluated this technique for early detection of trastuzumab-related cardi...

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Veröffentlicht in:	OncoTargets and therapy 2016-01, Vol.9, p.6785-6794
Hauptverfasser:	Coppola, Carmela, Riccio, Gennaro, Barbieri, Antonio, Monti, Maria Gaia, Piscopo, Giovanna, Rea, Domenica, Arra, Claudio, Maurea, Carlo, De Lorenzo, Claudia, Maurea, Nicola
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animal models Antineoplastic agents Apoptosis Breast cancer Cancer therapies Cardiac function Cardiomyopathy Cardiotoxicity Cardiovascular diseases Chemotherapy Complications and side effects Development and progression Dosage and administration Doxorubicin Echocardiography Fibrosis Functional morphology Heart Heart diseases Heart failure Immunotherapy Inflammation Kinases Microscopy Monoclonal antibodies Muscle contraction Original Research Risk factors Targeted cancer therapy Toxicity Trastuzumab Ventricle
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