Removal of the 5-nitro-2-pyridine-sulfenyl protecting group from selenocysteine and cysteine by ascorbolysis

We previously reported on a method for the facile removal of 4‐methoxybenzyl and acetamidomethyl protecting groups from cysteine (Cys) and selenocysteine (Sec) using 2,2′‐dithiobis‐5‐nitropyridine dissolved in trifluoroacetic acid, with or without thioanisole. The use of this reaction mixture remove...

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Veröffentlicht in:	Journal of peptide science 2016-09, Vol.22 (9), p.571-576
Hauptverfasser:	Ste. Marie, Emma J., Ruggles, Erik L., Hondal, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	ascorbate Ascorbic Acid - chemistry cysteine Cysteine - chemistry deprotection disulfide Disulfides - chemistry Hydrogen-Ion Concentration Hydrolysis orthogonal Peptides protecting group Pyridines - chemistry selenocysteine Selenocysteine - chemistry Time Factors Trifluoroacetic Acid - chemistry
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