Inhibition of Interleukin-1β Decreases Aneurysm Formation and Progression in a Novel Model of Thoracic Aortic Aneurysms

BACKGROUND—Thoracic aortic aneurysms (TAAs) are common, but experimental TAA models are limited and the role of interleukin-1β (IL-1β) is undetermined. METHODS AND RESULTS—IL-1β protein was measured in human TAAs and control aortas, and IL-1β protein was increased ≈20-fold in human TAAs. To develop...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2014-09, Vol.130 (11 Suppl 1), p.S51-S59
Hauptverfasser:	Johnston, William F, Salmon, Morgan, Pope, Nicolas H, Meher, Akshaya, Su, Gang, Stone, Matthew L, Lu, Guanyi, Owens, Gary K, Upchurch, Gilbert R, Ailawadi, Gorav
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Aortic Aneurysm, Thoracic - chemically induced Aortic Aneurysm, Thoracic - drug therapy Aortic Aneurysm, Thoracic - pathology Aortic Aneurysm, Thoracic - prevention & control Caspase 1 - physiology Comorbidity Disease Models, Animal Disease Progression Drug Evaluation, Preclinical Female Humans Interleukin 1 Receptor Antagonist Protein - pharmacology Interleukin 1 Receptor Antagonist Protein - therapeutic use Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - deficiency Interleukin-1beta - genetics Macrophages - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Muscle, Smooth, Vascular - pathology Pancreatic Elastase - toxicity Receptors, Interleukin-1 - antagonists & inhibitors Receptors, Interleukin-1 - deficiency Receptors, Interleukin-1 - genetics Thoracotomy
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