Differences in Patient Characteristics and Midterm Outcome Between Asian and European Patients Treated with Radiofrequency Ablation for Hepatocellular Carcinoma
Purpose The aim of this study was to compare patient characteristics and midterm outcomes after RFA for unresectable Hepatocellular carcinoma (HCC) in Asian and European cohorts. Materials and Methods The study was based on retrospective analysis of 279 patients (mean 64.8 ± 12.1 years; 208 males) t...
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| Veröffentlicht in: | Cardiovascular and interventional radiology 2016-12, Vol.39 (12), p.1708-1715 |
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| creator | Burgmans, Mark Christiaan Too, Chow Wei Fiocco, Marta Kerbert, Annarein J. C. Lo, Richard Hoau Gong Schaapman, Jelte J. van Erkel, Arian R. Coenraad, Minneke J. Tan, Bien Soo |
| description | Purpose
The aim of this study was to compare patient characteristics and midterm outcomes after RFA for unresectable Hepatocellular carcinoma (HCC) in Asian and European cohorts.
Materials and Methods
The study was based on retrospective analysis of 279 patients (mean 64.8 ± 12.1 years; 208 males) treated with RFA for de novo HCC in tertiary referral centers in Singapore and the Netherlands, with median follow-up of 28.2 months (quartiles: 13.1–40.5 months). Cumulative incidence of recurrence and death were analyzed using a competing risk model.
Results
Age was higher in the Asian group: 66.5 versus 60.1 years (
p
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| doi_str_mv | 10.1007/s00270-016-1462-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5097094</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1846411937</sourcerecordid><originalsourceid>FETCH-LOGICAL-c531t-66a031877dbeb5c407507bbc3797077ec5f4558cdfd0aadefba2cd1e4914adba3</originalsourceid><addsrcrecordid>eNqNklFrFDEUhQdR7Fr9Ab5IwBdfRpNMMtl9Eda1WqFSkQq-hTvJnW7KTLImGUv_TX9qs926rA-CT4Hku-fkHk5VvWT0LaNUvUuUckVrytqaiZbX6lE1Y6LhNZ23Px9XM8qUqJmU7Kh6ltIVpUzOuXxaHXHVKsYkm1W3H13fY0RvMBHnyTfIDn0mqzVEMBmjS9mZRMBb8tXZcjGS8ymbMCL5gPka0ZNlcuDviZMphg3CXiaRi4iQ0ZJrl9fkO1gX-oi_puJ3Q5bdULDgSR8iOcUN5GBwGKYBIllBNM6HEZ5XT3oYEr54OI-rH59OLlan9dn55y-r5VltZMNy3bZAGzZXynbYSSOoklR1nWnUQlGl0MheSDk3trcUwGLfATeWoVgwAbaD5rh6v9PdTN2I1pTfRxj0JroR4o0O4PTfL96t9WX4rSUtDgtRBF7vBEJJTCfjMpq1Cd6jyZrzVnDR0EK9ebCJocSQsh5d2m4NHsOUNJuLVjC2aNR_oE2r-KIVB9579CpM0Ze87ikmuBJbQbajTAwpRez32zGqt4XSu0LpUii9LZTezrw6jGU_8adBBeA7IJUnf4nxwPqfqne5ttmY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1836142747</pqid></control><display><type>article</type><title>Differences in Patient Characteristics and Midterm Outcome Between Asian and European Patients Treated with Radiofrequency Ablation for Hepatocellular Carcinoma</title><source>MEDLINE</source><source>Springer journals</source><creator>Burgmans, Mark Christiaan ; Too, Chow Wei ; Fiocco, Marta ; Kerbert, Annarein J. C. ; Lo, Richard Hoau Gong ; Schaapman, Jelte J. ; van Erkel, Arian R. ; Coenraad, Minneke J. ; Tan, Bien Soo</creator><creatorcontrib>Burgmans, Mark Christiaan ; Too, Chow Wei ; Fiocco, Marta ; Kerbert, Annarein J. C. ; Lo, Richard Hoau Gong ; Schaapman, Jelte J. ; van Erkel, Arian R. ; Coenraad, Minneke J. ; Tan, Bien Soo</creatorcontrib><description>Purpose
The aim of this study was to compare patient characteristics and midterm outcomes after RFA for unresectable Hepatocellular carcinoma (HCC) in Asian and European cohorts.
Materials and Methods
The study was based on retrospective analysis of 279 patients (mean 64.8 ± 12.1 years; 208 males) treated with RFA for de novo HCC in tertiary referral centers in Singapore and the Netherlands, with median follow-up of 28.2 months (quartiles: 13.1–40.5 months). Cumulative incidence of recurrence and death were analyzed using a competing risk model.
Results
Age was higher in the Asian group: 66.5 versus 60.1 years (
p
< 0.0001). The most common etiology was hepatitis B in the Asian group (48.0 %) and alcohol-induced cirrhosis in Europeans (54.4 %);
p
< 0.001. Asian patients had less advanced disease: 35.5, 55.0, and 3.0 %, respectively, had BCLC 0, A, and B versus 21.5, 58.2, and 15.2 % in the European group (
p
= 0.01). The cumulative incidences of recurrence in the Asian group at 1, 2, 3, and 5 years were 37.0, 56.4, 62.3, and 67.7 %, respectively, compared to 32.6, 47.2, 49.7, and 53.4 % in the European group (
p
= 0.474). At 1, 2, 3, and 5 years, the cumulative incidence rates of death in the Asian group were 2.0, 3.9, 4.9, and 4.9 %, respectively, corresponding to 7.7, 9.2, 14.1, and 21.0 % in the European group (
p
= 0.155).
Conclusion
Similar short-term treatment outcomes are achieved with RFA in HCC patients in the South-East Asian and Northern-European populations. Midterm recurrence and death rates differ between the groups as a result of differences in baseline patient characteristics and patient selection. Our study provides insight relevant to the design of future international studies.</description><identifier>ISSN: 0174-1551</identifier><identifier>EISSN: 1432-086X</identifier><identifier>DOI: 10.1007/s00270-016-1462-7</identifier><identifier>PMID: 27671151</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>ABLATION ; Age Factors ; Aged ; Asian Continental Ancestry Group - statistics & numerical data ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - surgery ; Cardiology ; Catheter Ablation - methods ; Causality ; Clinical Investigation ; Comorbidity ; COMPARATIVE EVALUATIONS ; DEATH ; ETIOLOGY ; European Continental Ancestry Group - statistics & numerical data ; Female ; Follow-Up Studies ; HAZARDS ; HEPATITIS ; Hepatitis B - epidemiology ; Hepatitis B virus ; HEPATOMAS ; Humans ; Imaging ; Incidence ; Liver Cirrhosis, Alcoholic - epidemiology ; Liver Neoplasms - epidemiology ; Liver Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local - epidemiology ; NETHERLANDS ; Nuclear Medicine ; PATIENTS ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOWAVE RADIATION ; Retrospective Studies ; SINGAPORE ; Treatment Outcome ; Ultrasound</subject><ispartof>Cardiovascular and interventional radiology, 2016-12, Vol.39 (12), p.1708-1715</ispartof><rights>The Author(s) 2016</rights><rights>Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-66a031877dbeb5c407507bbc3797077ec5f4558cdfd0aadefba2cd1e4914adba3</citedby><cites>FETCH-LOGICAL-c531t-66a031877dbeb5c407507bbc3797077ec5f4558cdfd0aadefba2cd1e4914adba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00270-016-1462-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00270-016-1462-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27671151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22642430$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Burgmans, Mark Christiaan</creatorcontrib><creatorcontrib>Too, Chow Wei</creatorcontrib><creatorcontrib>Fiocco, Marta</creatorcontrib><creatorcontrib>Kerbert, Annarein J. C.</creatorcontrib><creatorcontrib>Lo, Richard Hoau Gong</creatorcontrib><creatorcontrib>Schaapman, Jelte J.</creatorcontrib><creatorcontrib>van Erkel, Arian R.</creatorcontrib><creatorcontrib>Coenraad, Minneke J.</creatorcontrib><creatorcontrib>Tan, Bien Soo</creatorcontrib><title>Differences in Patient Characteristics and Midterm Outcome Between Asian and European Patients Treated with Radiofrequency Ablation for Hepatocellular Carcinoma</title><title>Cardiovascular and interventional radiology</title><addtitle>Cardiovasc Intervent Radiol</addtitle><addtitle>Cardiovasc Intervent Radiol</addtitle><description>Purpose
The aim of this study was to compare patient characteristics and midterm outcomes after RFA for unresectable Hepatocellular carcinoma (HCC) in Asian and European cohorts.
Materials and Methods
The study was based on retrospective analysis of 279 patients (mean 64.8 ± 12.1 years; 208 males) treated with RFA for de novo HCC in tertiary referral centers in Singapore and the Netherlands, with median follow-up of 28.2 months (quartiles: 13.1–40.5 months). Cumulative incidence of recurrence and death were analyzed using a competing risk model.
Results
Age was higher in the Asian group: 66.5 versus 60.1 years (
p
< 0.0001). The most common etiology was hepatitis B in the Asian group (48.0 %) and alcohol-induced cirrhosis in Europeans (54.4 %);
p
< 0.001. Asian patients had less advanced disease: 35.5, 55.0, and 3.0 %, respectively, had BCLC 0, A, and B versus 21.5, 58.2, and 15.2 % in the European group (
p
= 0.01). The cumulative incidences of recurrence in the Asian group at 1, 2, 3, and 5 years were 37.0, 56.4, 62.3, and 67.7 %, respectively, compared to 32.6, 47.2, 49.7, and 53.4 % in the European group (
p
= 0.474). At 1, 2, 3, and 5 years, the cumulative incidence rates of death in the Asian group were 2.0, 3.9, 4.9, and 4.9 %, respectively, corresponding to 7.7, 9.2, 14.1, and 21.0 % in the European group (
p
= 0.155).
Conclusion
Similar short-term treatment outcomes are achieved with RFA in HCC patients in the South-East Asian and Northern-European populations. Midterm recurrence and death rates differ between the groups as a result of differences in baseline patient characteristics and patient selection. Our study provides insight relevant to the design of future international studies.</description><subject>ABLATION</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cardiology</subject><subject>Catheter Ablation - methods</subject><subject>Causality</subject><subject>Clinical Investigation</subject><subject>Comorbidity</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>DEATH</subject><subject>ETIOLOGY</subject><subject>European Continental Ancestry Group - statistics & numerical data</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>HAZARDS</subject><subject>HEPATITIS</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B virus</subject><subject>HEPATOMAS</subject><subject>Humans</subject><subject>Imaging</subject><subject>Incidence</subject><subject>Liver Cirrhosis, Alcoholic - epidemiology</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>NETHERLANDS</subject><subject>Nuclear Medicine</subject><subject>PATIENTS</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOWAVE RADIATION</subject><subject>Retrospective Studies</subject><subject>SINGAPORE</subject><subject>Treatment Outcome</subject><subject>Ultrasound</subject><issn>0174-1551</issn><issn>1432-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNklFrFDEUhQdR7Fr9Ab5IwBdfRpNMMtl9Eda1WqFSkQq-hTvJnW7KTLImGUv_TX9qs926rA-CT4Hku-fkHk5VvWT0LaNUvUuUckVrytqaiZbX6lE1Y6LhNZ23Px9XM8qUqJmU7Kh6ltIVpUzOuXxaHXHVKsYkm1W3H13fY0RvMBHnyTfIDn0mqzVEMBmjS9mZRMBb8tXZcjGS8ymbMCL5gPka0ZNlcuDviZMphg3CXiaRi4iQ0ZJrl9fkO1gX-oi_puJ3Q5bdULDgSR8iOcUN5GBwGKYBIllBNM6HEZ5XT3oYEr54OI-rH59OLlan9dn55y-r5VltZMNy3bZAGzZXynbYSSOoklR1nWnUQlGl0MheSDk3trcUwGLfATeWoVgwAbaD5rh6v9PdTN2I1pTfRxj0JroR4o0O4PTfL96t9WX4rSUtDgtRBF7vBEJJTCfjMpq1Cd6jyZrzVnDR0EK9ebCJocSQsh5d2m4NHsOUNJuLVjC2aNR_oE2r-KIVB9579CpM0Ze87ikmuBJbQbajTAwpRez32zGqt4XSu0LpUii9LZTezrw6jGU_8adBBeA7IJUnf4nxwPqfqne5ttmY</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Burgmans, Mark Christiaan</creator><creator>Too, Chow Wei</creator><creator>Fiocco, Marta</creator><creator>Kerbert, Annarein J. C.</creator><creator>Lo, Richard Hoau Gong</creator><creator>Schaapman, Jelte J.</creator><creator>van Erkel, Arian R.</creator><creator>Coenraad, Minneke J.</creator><creator>Tan, Bien Soo</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20161201</creationdate><title>Differences in Patient Characteristics and Midterm Outcome Between Asian and European Patients Treated with Radiofrequency Ablation for Hepatocellular Carcinoma</title><author>Burgmans, Mark Christiaan ; Too, Chow Wei ; Fiocco, Marta ; Kerbert, Annarein J. C. ; Lo, Richard Hoau Gong ; Schaapman, Jelte J. ; van Erkel, Arian R. ; Coenraad, Minneke J. ; Tan, Bien Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-66a031877dbeb5c407507bbc3797077ec5f4558cdfd0aadefba2cd1e4914adba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>ABLATION</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - statistics & numerical data</topic><topic>Carcinoma, Hepatocellular - epidemiology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cardiology</topic><topic>Catheter Ablation - methods</topic><topic>Causality</topic><topic>Clinical Investigation</topic><topic>Comorbidity</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>DEATH</topic><topic>ETIOLOGY</topic><topic>European Continental Ancestry Group - statistics & numerical data</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>HAZARDS</topic><topic>HEPATITIS</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B virus</topic><topic>HEPATOMAS</topic><topic>Humans</topic><topic>Imaging</topic><topic>Incidence</topic><topic>Liver Cirrhosis, Alcoholic - epidemiology</topic><topic>Liver Neoplasms - epidemiology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>NETHERLANDS</topic><topic>Nuclear Medicine</topic><topic>PATIENTS</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOWAVE RADIATION</topic><topic>Retrospective Studies</topic><topic>SINGAPORE</topic><topic>Treatment Outcome</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burgmans, Mark Christiaan</creatorcontrib><creatorcontrib>Too, Chow Wei</creatorcontrib><creatorcontrib>Fiocco, Marta</creatorcontrib><creatorcontrib>Kerbert, Annarein J. C.</creatorcontrib><creatorcontrib>Lo, Richard Hoau Gong</creatorcontrib><creatorcontrib>Schaapman, Jelte J.</creatorcontrib><creatorcontrib>van Erkel, Arian R.</creatorcontrib><creatorcontrib>Coenraad, Minneke J.</creatorcontrib><creatorcontrib>Tan, Bien Soo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cardiovascular and interventional radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burgmans, Mark Christiaan</au><au>Too, Chow Wei</au><au>Fiocco, Marta</au><au>Kerbert, Annarein J. C.</au><au>Lo, Richard Hoau Gong</au><au>Schaapman, Jelte J.</au><au>van Erkel, Arian R.</au><au>Coenraad, Minneke J.</au><au>Tan, Bien Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in Patient Characteristics and Midterm Outcome Between Asian and European Patients Treated with Radiofrequency Ablation for Hepatocellular Carcinoma</atitle><jtitle>Cardiovascular and interventional radiology</jtitle><stitle>Cardiovasc Intervent Radiol</stitle><addtitle>Cardiovasc Intervent Radiol</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>39</volume><issue>12</issue><spage>1708</spage><epage>1715</epage><pages>1708-1715</pages><issn>0174-1551</issn><eissn>1432-086X</eissn><abstract>Purpose
The aim of this study was to compare patient characteristics and midterm outcomes after RFA for unresectable Hepatocellular carcinoma (HCC) in Asian and European cohorts.
Materials and Methods
The study was based on retrospective analysis of 279 patients (mean 64.8 ± 12.1 years; 208 males) treated with RFA for de novo HCC in tertiary referral centers in Singapore and the Netherlands, with median follow-up of 28.2 months (quartiles: 13.1–40.5 months). Cumulative incidence of recurrence and death were analyzed using a competing risk model.
Results
Age was higher in the Asian group: 66.5 versus 60.1 years (
p
< 0.0001). The most common etiology was hepatitis B in the Asian group (48.0 %) and alcohol-induced cirrhosis in Europeans (54.4 %);
p
< 0.001. Asian patients had less advanced disease: 35.5, 55.0, and 3.0 %, respectively, had BCLC 0, A, and B versus 21.5, 58.2, and 15.2 % in the European group (
p
= 0.01). The cumulative incidences of recurrence in the Asian group at 1, 2, 3, and 5 years were 37.0, 56.4, 62.3, and 67.7 %, respectively, compared to 32.6, 47.2, 49.7, and 53.4 % in the European group (
p
= 0.474). At 1, 2, 3, and 5 years, the cumulative incidence rates of death in the Asian group were 2.0, 3.9, 4.9, and 4.9 %, respectively, corresponding to 7.7, 9.2, 14.1, and 21.0 % in the European group (
p
= 0.155).
Conclusion
Similar short-term treatment outcomes are achieved with RFA in HCC patients in the South-East Asian and Northern-European populations. Midterm recurrence and death rates differ between the groups as a result of differences in baseline patient characteristics and patient selection. Our study provides insight relevant to the design of future international studies.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27671151</pmid><doi>10.1007/s00270-016-1462-7</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0174-1551 |
| ispartof | Cardiovascular and interventional radiology, 2016-12, Vol.39 (12), p.1708-1715 |
| issn | 0174-1551 1432-086X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5097094 |
| source | MEDLINE; Springer journals |
| subjects | ABLATION Age Factors Aged Asian Continental Ancestry Group - statistics & numerical data Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - surgery Cardiology Catheter Ablation - methods Causality Clinical Investigation Comorbidity COMPARATIVE EVALUATIONS DEATH ETIOLOGY European Continental Ancestry Group - statistics & numerical data Female Follow-Up Studies HAZARDS HEPATITIS Hepatitis B - epidemiology Hepatitis B virus HEPATOMAS Humans Imaging Incidence Liver Cirrhosis, Alcoholic - epidemiology Liver Neoplasms - epidemiology Liver Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - epidemiology NETHERLANDS Nuclear Medicine PATIENTS Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOWAVE RADIATION Retrospective Studies SINGAPORE Treatment Outcome Ultrasound |
| title | Differences in Patient Characteristics and Midterm Outcome Between Asian and European Patients Treated with Radiofrequency Ablation for Hepatocellular Carcinoma |
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