mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors
Mammalian target of rapamycin complex 1 (mTORC1) has an essential role in dendritic mRNA translation and participates in mechanisms underlying alcohol-drinking and reconsolidation of alcohol-related memories. Here, we report that excessive alcohol consumption increases the translation of downstream...
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| Veröffentlicht in: | Molecular psychiatry 2017-01, Vol.22 (1), p.89-101 |
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| creator | Liu, F Laguesse, S Legastelois, R Morisot, N Ben Hamida, S Ron, D |
| description | Mammalian target of rapamycin complex 1 (mTORC1) has an essential role in dendritic mRNA translation and participates in mechanisms underlying alcohol-drinking and reconsolidation of alcohol-related memories. Here, we report that excessive alcohol consumption increases the translation of downstream targets of mTORC1, including collapsin response mediator protein-2 (
CRMP-2
), in the nucleus accumbens (NAc) of rodents. We show that alcohol-mediated induction of
CRMP-2
translation is mTORC1-dependent, leading to increased CRMP-2 protein levels. Furthermore, we demonstrate that alcohol intake also blocks glycogen synthase kinase-3β (GSK-3β)-phosphorylation of CRMP-2, which results in elevated binding of CRMP-2 to microtubules and a concomitant increase in microtubule content. Finally, we show that systemic administration of the CRMP-2 inhibitor lacosamide, or knockdown of
CRMP-2
in the NAc decreases excessive alcohol intake. These results suggest that CRMP-2 in the NAc is a convergent point that receives inputs from two signaling pathways, mTORC1 and GSK-3β, that in turn drives excessive alcohol-drinking behaviors. |
| doi_str_mv | 10.1038/mp.2016.12 |
| format | Article |
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CRMP-2
), in the nucleus accumbens (NAc) of rodents. We show that alcohol-mediated induction of
CRMP-2
translation is mTORC1-dependent, leading to increased CRMP-2 protein levels. Furthermore, we demonstrate that alcohol intake also blocks glycogen synthase kinase-3β (GSK-3β)-phosphorylation of CRMP-2, which results in elevated binding of CRMP-2 to microtubules and a concomitant increase in microtubule content. Finally, we show that systemic administration of the CRMP-2 inhibitor lacosamide, or knockdown of
CRMP-2
in the NAc decreases excessive alcohol intake. These results suggest that CRMP-2 in the NAc is a convergent point that receives inputs from two signaling pathways, mTORC1 and GSK-3β, that in turn drives excessive alcohol-drinking behaviors.</description><identifier>ISSN: 1359-4184</identifier><identifier>ISSN: 1476-5578</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/mp.2016.12</identifier><identifier>PMID: 26952865</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/89 ; 14/1 ; 14/19 ; 38/89 ; 38/90 ; 631/378 ; 64/60 ; 692/699/476/5 ; 82/29 ; 96/1 ; Acetamides ; Addictions ; Alcohol Drinking ; Alcohol Drinking - metabolism ; Alcohol use ; Animals ; Behavioral Sciences ; Biological Psychology ; C57BL mouse ; Cellular signal transduction ; CRMP 2 gene ; Dendrites ; Dendrites - metabolism ; Drinking (Alcoholic beverages) ; Drinking water ; Ethanol ; Ethanol - metabolism ; Genetic aspects ; Genetic regulation ; Glycogen Synthase Kinase 3 ; Glycogen Synthase Kinase 3 - metabolism ; Glycogen Synthase Kinase 3 beta ; Glycogen Synthase Kinase 3 beta - metabolism ; Health aspects ; Human health sciences ; Humidity ; Intercellular Signaling Peptides and Proteins ; Intercellular Signaling Peptides and Proteins - metabolism ; Intercellular Signaling Peptides and Proteins - physiology ; Kinases ; Laboratory animals ; Lacosamide ; Life Sciences ; Long Evans rat ; Male ; Mechanistic Target of Rapamycin Complex 1 ; Medicine ; Medicine & Public Health ; Mice ; Mice, Inbred C57BL ; Microtubules ; Multiprotein Complexes ; Multiprotein Complexes - metabolism ; Nerve Tissue Proteins ; Nerve Tissue Proteins - metabolism ; Nerve Tissue Proteins - physiology ; Neurologie ; Neurology ; Neurosciences ; Nucleus Accumbens ; Nucleus Accumbens - metabolism ; Original ; original-article ; Pharmacotherapy ; Phosphorylation ; Phosphotransferases ; Protein Biosynthesis ; Protein Biosynthesis - physiology ; Proteins ; Psychiatry ; Psychological aspects ; Rats ; Rats, Long-Evans ; RNA translation ; Sciences de la santé humaine ; Signal Transduction ; TOR Serine-Threonine Kinases ; TOR Serine-Threonine Kinases - metabolism</subject><ispartof>Molecular psychiatry, 2017-01, Vol.22 (1), p.89-101</ispartof><rights>The Author(s) 2016</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2017</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2016 Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-59fc076d4195c3f42aee21b136afe72460513c961ebe6dd2a1577098893782563</citedby><cites>FETCH-LOGICAL-c620t-59fc076d4195c3f42aee21b136afe72460513c961ebe6dd2a1577098893782563</cites><orcidid>0000-0001-9636-9432</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/mp.2016.12$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/mp.2016.12$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,778,782,883,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26952865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://u-picardie.hal.science/hal-04052852$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, F</creatorcontrib><creatorcontrib>Laguesse, S</creatorcontrib><creatorcontrib>Legastelois, R</creatorcontrib><creatorcontrib>Morisot, N</creatorcontrib><creatorcontrib>Ben Hamida, S</creatorcontrib><creatorcontrib>Ron, D</creatorcontrib><title>mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Mammalian target of rapamycin complex 1 (mTORC1) has an essential role in dendritic mRNA translation and participates in mechanisms underlying alcohol-drinking and reconsolidation of alcohol-related memories. Here, we report that excessive alcohol consumption increases the translation of downstream targets of mTORC1, including collapsin response mediator protein-2 (
CRMP-2
), in the nucleus accumbens (NAc) of rodents. We show that alcohol-mediated induction of
CRMP-2
translation is mTORC1-dependent, leading to increased CRMP-2 protein levels. Furthermore, we demonstrate that alcohol intake also blocks glycogen synthase kinase-3β (GSK-3β)-phosphorylation of CRMP-2, which results in elevated binding of CRMP-2 to microtubules and a concomitant increase in microtubule content. Finally, we show that systemic administration of the CRMP-2 inhibitor lacosamide, or knockdown of
CRMP-2
in the NAc decreases excessive alcohol intake. These results suggest that CRMP-2 in the NAc is a convergent point that receives inputs from two signaling pathways, mTORC1 and GSK-3β, that in turn drives excessive alcohol-drinking behaviors.</description><subject>13/89</subject><subject>14/1</subject><subject>14/19</subject><subject>38/89</subject><subject>38/90</subject><subject>631/378</subject><subject>64/60</subject><subject>692/699/476/5</subject><subject>82/29</subject><subject>96/1</subject><subject>Acetamides</subject><subject>Addictions</subject><subject>Alcohol Drinking</subject><subject>Alcohol Drinking - metabolism</subject><subject>Alcohol use</subject><subject>Animals</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>C57BL mouse</subject><subject>Cellular signal transduction</subject><subject>CRMP 2 gene</subject><subject>Dendrites</subject><subject>Dendrites - metabolism</subject><subject>Drinking (Alcoholic beverages)</subject><subject>Drinking water</subject><subject>Ethanol</subject><subject>Ethanol - metabolism</subject><subject>Genetic aspects</subject><subject>Genetic regulation</subject><subject>Glycogen Synthase Kinase 3</subject><subject>Glycogen Synthase Kinase 3 - metabolism</subject><subject>Glycogen Synthase Kinase 3 beta</subject><subject>Glycogen Synthase Kinase 3 beta - metabolism</subject><subject>Health aspects</subject><subject>Human health sciences</subject><subject>Humidity</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Intercellular Signaling Peptides and Proteins - physiology</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Lacosamide</subject><subject>Life Sciences</subject><subject>Long Evans rat</subject><subject>Male</subject><subject>Mechanistic Target of Rapamycin Complex 1</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microtubules</subject><subject>Multiprotein Complexes</subject><subject>Multiprotein Complexes - metabolism</subject><subject>Nerve Tissue Proteins</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Neurologie</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nucleus Accumbens</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Original</subject><subject>original-article</subject><subject>Pharmacotherapy</subject><subject>Phosphorylation</subject><subject>Phosphotransferases</subject><subject>Protein Biosynthesis</subject><subject>Protein Biosynthesis - physiology</subject><subject>Proteins</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>RNA translation</subject><subject>Sciences de la santé humaine</subject><subject>Signal Transduction</subject><subject>TOR Serine-Threonine Kinases</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><issn>1359-4184</issn><issn>1476-5578</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkstq3DAUhk1paZJpN32AYuimFzzVxZKtTWAY2qYwECjpWsjysUepLbmSPTQP0XeOPDMNSdpFkUFC5_t_-VyS5BVGS4xo-bEflgRhvsTkSXKK84JnjBXl03imTGQ5LvOT5CyEa4TmIHuenBAuGCk5O01-91eX39Y4q2EAW4Md09ErGzo1GmdT16TadZ0agrGphzA4GyDtoTZqdD4dvBvB2IyktTc7CKmFyTtVq2Hc60M6RU_f3RjbpvBLQwgRS1Wn3dZ1WRTZH3Oogq3aGefDi-RZo7oAL4_7Ivn--dPV-iLbXH75ul5tMs0JGjMmGo0KXudYME2bnCgAgitMuWqgIDlHDFMtOIYKeF0ThVlRIFGWghYlYZwukvOD7zBVMRsd8_aqk4M3vfI30ikjH0as2crW7SRDokAURQN6MOgMtCCdr4zckb1wf566ViotK5CE8FISShjOo-rdQbV99NjFaiPnO5Sj2BdGdjiyb4-_6N3PCcIoexM0xGZYcFOQuGQiF7hA_D9QwjnHsQARffMIvXaTt7HWsyGiBSJ7wyPVqg6ksY2LRdCzqVzlRc6woPFbJMt_UHHV0BvtLDQm3j8QvD8ItHcheGjuaoCRnCdZ9oOcJ1liEuHX91t0h_4Z3Qh8OAAhhmwL_l4qf9vdAjHj_JM</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Liu, F</creator><creator>Laguesse, S</creator><creator>Legastelois, R</creator><creator>Morisot, N</creator><creator>Ben Hamida, S</creator><creator>Ron, D</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>Q33</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9636-9432</orcidid></search><sort><creationdate>20170101</creationdate><title>mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors</title><author>Liu, F ; Laguesse, S ; Legastelois, R ; Morisot, N ; Ben Hamida, S ; Ron, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-59fc076d4195c3f42aee21b136afe72460513c961ebe6dd2a1577098893782563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>13/89</topic><topic>14/1</topic><topic>14/19</topic><topic>38/89</topic><topic>38/90</topic><topic>631/378</topic><topic>64/60</topic><topic>692/699/476/5</topic><topic>82/29</topic><topic>96/1</topic><topic>Acetamides</topic><topic>Addictions</topic><topic>Alcohol Drinking</topic><topic>Alcohol Drinking - metabolism</topic><topic>Alcohol use</topic><topic>Animals</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>C57BL mouse</topic><topic>Cellular signal transduction</topic><topic>CRMP 2 gene</topic><topic>Dendrites</topic><topic>Dendrites - metabolism</topic><topic>Drinking (Alcoholic beverages)</topic><topic>Drinking water</topic><topic>Ethanol</topic><topic>Ethanol - metabolism</topic><topic>Genetic aspects</topic><topic>Genetic regulation</topic><topic>Glycogen Synthase Kinase 3</topic><topic>Glycogen Synthase Kinase 3 - metabolism</topic><topic>Glycogen Synthase Kinase 3 beta</topic><topic>Glycogen Synthase Kinase 3 beta - metabolism</topic><topic>Health aspects</topic><topic>Human health sciences</topic><topic>Humidity</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Intercellular Signaling Peptides and Proteins - physiology</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Lacosamide</topic><topic>Life Sciences</topic><topic>Long Evans rat</topic><topic>Male</topic><topic>Mechanistic Target of Rapamycin Complex 1</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microtubules</topic><topic>Multiprotein Complexes</topic><topic>Multiprotein Complexes - metabolism</topic><topic>Nerve Tissue Proteins</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Neurologie</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Nucleus Accumbens</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Original</topic><topic>original-article</topic><topic>Pharmacotherapy</topic><topic>Phosphorylation</topic><topic>Phosphotransferases</topic><topic>Protein Biosynthesis</topic><topic>Protein Biosynthesis - physiology</topic><topic>Proteins</topic><topic>Psychiatry</topic><topic>Psychological aspects</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>RNA translation</topic><topic>Sciences de la santé humaine</topic><topic>Signal Transduction</topic><topic>TOR Serine-Threonine Kinases</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, F</creatorcontrib><creatorcontrib>Laguesse, S</creatorcontrib><creatorcontrib>Legastelois, R</creatorcontrib><creatorcontrib>Morisot, N</creatorcontrib><creatorcontrib>Ben Hamida, S</creatorcontrib><creatorcontrib>Ron, D</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, F</au><au>Laguesse, S</au><au>Legastelois, R</au><au>Morisot, N</au><au>Ben Hamida, S</au><au>Ron, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>22</volume><issue>1</issue><spage>89</spage><epage>101</epage><pages>89-101</pages><issn>1359-4184</issn><issn>1476-5578</issn><eissn>1476-5578</eissn><abstract>Mammalian target of rapamycin complex 1 (mTORC1) has an essential role in dendritic mRNA translation and participates in mechanisms underlying alcohol-drinking and reconsolidation of alcohol-related memories. Here, we report that excessive alcohol consumption increases the translation of downstream targets of mTORC1, including collapsin response mediator protein-2 (
CRMP-2
), in the nucleus accumbens (NAc) of rodents. We show that alcohol-mediated induction of
CRMP-2
translation is mTORC1-dependent, leading to increased CRMP-2 protein levels. Furthermore, we demonstrate that alcohol intake also blocks glycogen synthase kinase-3β (GSK-3β)-phosphorylation of CRMP-2, which results in elevated binding of CRMP-2 to microtubules and a concomitant increase in microtubule content. Finally, we show that systemic administration of the CRMP-2 inhibitor lacosamide, or knockdown of
CRMP-2
in the NAc decreases excessive alcohol intake. These results suggest that CRMP-2 in the NAc is a convergent point that receives inputs from two signaling pathways, mTORC1 and GSK-3β, that in turn drives excessive alcohol-drinking behaviors.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26952865</pmid><doi>10.1038/mp.2016.12</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-9636-9432</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-4184 |
| ispartof | Molecular psychiatry, 2017-01, Vol.22 (1), p.89-101 |
| issn | 1359-4184 1476-5578 1476-5578 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5097030 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 13/89 14/1 14/19 38/89 38/90 631/378 64/60 692/699/476/5 82/29 96/1 Acetamides Addictions Alcohol Drinking Alcohol Drinking - metabolism Alcohol use Animals Behavioral Sciences Biological Psychology C57BL mouse Cellular signal transduction CRMP 2 gene Dendrites Dendrites - metabolism Drinking (Alcoholic beverages) Drinking water Ethanol Ethanol - metabolism Genetic aspects Genetic regulation Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Glycogen Synthase Kinase 3 beta - metabolism Health aspects Human health sciences Humidity Intercellular Signaling Peptides and Proteins Intercellular Signaling Peptides and Proteins - metabolism Intercellular Signaling Peptides and Proteins - physiology Kinases Laboratory animals Lacosamide Life Sciences Long Evans rat Male Mechanistic Target of Rapamycin Complex 1 Medicine Medicine & Public Health Mice Mice, Inbred C57BL Microtubules Multiprotein Complexes Multiprotein Complexes - metabolism Nerve Tissue Proteins Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Neurologie Neurology Neurosciences Nucleus Accumbens Nucleus Accumbens - metabolism Original original-article Pharmacotherapy Phosphorylation Phosphotransferases Protein Biosynthesis Protein Biosynthesis - physiology Proteins Psychiatry Psychological aspects Rats Rats, Long-Evans RNA translation Sciences de la santé humaine Signal Transduction TOR Serine-Threonine Kinases TOR Serine-Threonine Kinases - metabolism |
| title | mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A18%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=mTORC1-dependent%20translation%20of%20collapsin%20response%20mediator%20protein-2%20drives%20neuroadaptations%20underlying%20excessive%20alcohol-drinking%20behaviors&rft.jtitle=Molecular%20psychiatry&rft.au=Liu,%20F&rft.date=2017-01-01&rft.volume=22&rft.issue=1&rft.spage=89&rft.epage=101&rft.pages=89-101&rft.issn=1359-4184&rft.eissn=1476-5578&rft_id=info:doi/10.1038/mp.2016.12&rft_dat=%3Cgale_pubme%3EA474519319%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1850370206&rft_id=info:pmid/26952865&rft_galeid=A474519319&rfr_iscdi=true |