Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function

Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-function mutations in the Ca2+ release-activated Ca2+ (CRAC) channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE), and patients with these CRAC channel mutations suffer from anhidrosis and hyper...

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Veröffentlicht in:	The Journal of clinical investigation 2016-11, Vol.126 (11), p.4303-4318
Hauptverfasser:	Concepcion, Axel R, Vaeth, Martin, Wagner, 2nd, Larry E, Eckstein, Miriam, Hecht, Lee, Yang, Jun, Crottes, David, Seidl, Maximilian, Shin, Hyosup P, Weidinger, Carl, Cameron, Scott, Turvey, Stuart E, Issekutz, Thomas, Meyts, Isabelle, Lacruz, Rodrigo S, Cuk, Mario, Yule, David I, Feske, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anoctamin-1 Aquaporin 5 - genetics Aquaporin 5 - metabolism Calcium Signaling - physiology Chloride Channels - genetics Chloride Channels - metabolism Female Humans Male Mice Mice, Knockout Neoplasm Proteins - genetics Neoplasm Proteins - metabolism ORAI1 Protein - genetics ORAI1 Protein - metabolism Stromal Interaction Molecule 1 - genetics Stromal Interaction Molecule 1 - metabolism Stromal Interaction Molecule 2 - genetics Stromal Interaction Molecule 2 - metabolism Sweat - secretion Sweat Glands - metabolism
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