Effect of methanolic leaf extract of Talinum triangulare (Jacq). willd. on biochemical parameters in diet induced dyslipidemia wistar rats
Objective: To investigate the effect of methanolic leaf extract of Talinum triangulare on hematological parameters, enzymatic and non-enzymatic antioxidant status,and serum lipid in Wistar rats fed standard laboratory, or 2% cholesterol-enrich diet. Material and Methods: Wistar rats (180-210g) divid...
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| description | Objective: To investigate the effect of methanolic leaf extract of Talinum triangulare on hematological parameters, enzymatic and non-enzymatic antioxidant status,and serum lipid in Wistar rats fed standard laboratory, or 2% cholesterol-enrich diet. Material and Methods: Wistar rats (180-210g) divided into six groups of six animals (males) each were fed 2% cholesterol-enriched diet and orally treated with 0.9% saline or extract of Talinum triangulare (250, 500, and 1000 mg/kg per body weight) daily for eight weeks. Lipid profile, lipid peroxidation (MDA), hematological parameters, and their functional indices and serum antioxidant enzymes (catalase, glutathione -S-transferase, and superoxide dismutase) activities and glutathione status were assessed in normal and diet-induced hypercholesterolemic extract treated rats and compared with the rats treated with 100 mg/kg per bwt standard drug gemfibrozil. Results: A significant (P < 0.05) increase in lipid profile (total glyceride, total cholestrol, low-density lipoprotein, and very low-density lipoprotein), MDA and reduction (P < 0.05) in enzymatic and nonenzymatic antioxidant status coupled with alterations in hematological parameters was observed in the serum of hypercholesterolemic rats when compared with animals on a normal diet. Coadministration of methanolic leaf extracts of Talinum triangulare or gemfibrozil significantly (P < 0.05) restored the elevated serum lipid profile, MDA, and the deranged hematological parameters to near normal. The extract also protected against hypercholesterolemic-induced diminished enzymatic and nonenzymatic antioxidant status. The activities of the plant extract are dose (250, 500, and 1000 mg/kg) dependent and it compared favorably with the standard drug gemfibrozil. Conclusion: The present study suggested that the extract of Talinum triangulare might protect against hypercholesterolemic-induced altered lipid profiles, oxidative stress, and also improve the status of antioxidant defense system and hematopoiesis.
Abbreviation used: Lipid peroxidation (MDA), (catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), glutathione (GSH), Thrombocytes indices (PLT), Red blood cell (RBC), Packed cell volume (PVC), Mean corpuscular hemoglobin(MCH), Mean corpuscular hemoglobin concentration (MCHC), Total glyceride (TG), Very low density lipoprotein (VLDL), Total cholesterol (TC), Low density lipoprotein (LDL), High density lipoprotein (HDL) and 3-Hydroxy-3-methyl |
| doi_str_mv | 10.4103/0973-1296.192194 |
| format | Article |
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Abbreviation used: Lipid peroxidation (MDA), (catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), glutathione (GSH), Thrombocytes indices (PLT), Red blood cell (RBC), Packed cell volume (PVC), Mean corpuscular hemoglobin(MCH), Mean corpuscular hemoglobin concentration (MCHC), Total glyceride (TG), Very low density lipoprotein (VLDL), Total cholesterol (TC), Low density lipoprotein (LDL), High density lipoprotein (HDL) and 3-Hydroxy-3-methyl-glutaryl-CoA reductase(HMG-CoA).</description><identifier>ISSN: 0973-1296</identifier><identifier>EISSN: 0976-4062</identifier><identifier>DOI: 10.4103/0973-1296.192194</identifier><identifier>PMID: 27867278</identifier><language>eng</language><publisher>United States: Wolters Kluwer India Pvt. Ltd</publisher><subject>Antioxidants ; Atherosclerosis ; Biosynthesis ; Blood platelets ; Caryophyllidae ; Cholesterol ; Colleges & universities ; Conflicts of interest ; Drug dosages ; Free radicals ; Genetically modified mice ; Health aspects ; Hematology ; Hypercholesterolemia ; Laboratory animals ; Lipid peroxidation ; Lipids ; Lipoproteins ; Original ; Oxidative stress ; Plant extracts ; Prevention ; Rodents ; Thrombosis</subject><ispartof>Pharmacognosy Magazine, 2016-10, Vol.12 (48), p.333-339</ispartof><rights>COPYRIGHT 2016 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Oct-Dec 2016</rights><rights>Copyright: © Pharmacognosy Magazine 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096282/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096282/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27867278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olorunnisola, Olubukola</creatorcontrib><creatorcontrib>Adetutu, Adewale</creatorcontrib><creatorcontrib>Afolayan, Anthony</creatorcontrib><creatorcontrib>Owoade, Abiodun</creatorcontrib><title>Effect of methanolic leaf extract of Talinum triangulare (Jacq). willd. on biochemical parameters in diet induced dyslipidemia wistar rats</title><title>Pharmacognosy Magazine</title><addtitle>Pharmacogn Mag</addtitle><description>Objective: To investigate the effect of methanolic leaf extract of Talinum triangulare on hematological parameters, enzymatic and non-enzymatic antioxidant status,and serum lipid in Wistar rats fed standard laboratory, or 2% cholesterol-enrich diet. Material and Methods: Wistar rats (180-210g) divided into six groups of six animals (males) each were fed 2% cholesterol-enriched diet and orally treated with 0.9% saline or extract of Talinum triangulare (250, 500, and 1000 mg/kg per body weight) daily for eight weeks. Lipid profile, lipid peroxidation (MDA), hematological parameters, and their functional indices and serum antioxidant enzymes (catalase, glutathione -S-transferase, and superoxide dismutase) activities and glutathione status were assessed in normal and diet-induced hypercholesterolemic extract treated rats and compared with the rats treated with 100 mg/kg per bwt standard drug gemfibrozil. Results: A significant (P < 0.05) increase in lipid profile (total glyceride, total cholestrol, low-density lipoprotein, and very low-density lipoprotein), MDA and reduction (P < 0.05) in enzymatic and nonenzymatic antioxidant status coupled with alterations in hematological parameters was observed in the serum of hypercholesterolemic rats when compared with animals on a normal diet. Coadministration of methanolic leaf extracts of Talinum triangulare or gemfibrozil significantly (P < 0.05) restored the elevated serum lipid profile, MDA, and the deranged hematological parameters to near normal. The extract also protected against hypercholesterolemic-induced diminished enzymatic and nonenzymatic antioxidant status. The activities of the plant extract are dose (250, 500, and 1000 mg/kg) dependent and it compared favorably with the standard drug gemfibrozil. Conclusion: The present study suggested that the extract of Talinum triangulare might protect against hypercholesterolemic-induced altered lipid profiles, oxidative stress, and also improve the status of antioxidant defense system and hematopoiesis.
Abbreviation used: Lipid peroxidation (MDA), (catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), glutathione (GSH), Thrombocytes indices (PLT), Red blood cell (RBC), Packed cell volume (PVC), Mean corpuscular hemoglobin(MCH), Mean corpuscular hemoglobin concentration (MCHC), Total glyceride (TG), Very low density lipoprotein (VLDL), Total cholesterol (TC), Low density lipoprotein (LDL), High density lipoprotein (HDL) and 3-Hydroxy-3-methyl-glutaryl-CoA reductase(HMG-CoA).</description><subject>Antioxidants</subject><subject>Atherosclerosis</subject><subject>Biosynthesis</subject><subject>Blood platelets</subject><subject>Caryophyllidae</subject><subject>Cholesterol</subject><subject>Colleges & universities</subject><subject>Conflicts of interest</subject><subject>Drug dosages</subject><subject>Free radicals</subject><subject>Genetically modified mice</subject><subject>Health aspects</subject><subject>Hematology</subject><subject>Hypercholesterolemia</subject><subject>Laboratory animals</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Original</subject><subject>Oxidative stress</subject><subject>Plant extracts</subject><subject>Prevention</subject><subject>Rodents</subject><subject>Thrombosis</subject><issn>0973-1296</issn><issn>0976-4062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1v1DAQhiMEoqVw54QscSmHLLYTJ84FqapaPrQSl3K2Jv7YdevYWzvp0r_Ar65D2kIRsmRbM8-88ozfonhL8KomuPqIu7YqCe2aFeko6epnxWEONWWNG_r8931JHxSvUrrEmHGC25fFAW150-btsPh1ZoyWIwoGDXrcgg_OSuQ0GKR_jhGW1AU466cBjdGC30wOokbH30Bef1ihvXVOrVDwqLdBbvVgJTi0gwhZUMeErEfK6jGfapJaIXWbnN1ZlUnI1WmEiCKM6XXxwoBL-s39eVT8OD-7OP1Srr9__np6si43DGNXyhZjyhtdt32lQNYUg2FGA6NUYgNc9T3p216xjkhJWgWKGV5x3rWU9lxCdVR8WnR3Uz9oJbXPfTqxi3aAeCsCWPE04-1WbMKNYLhrKKdZ4PheIIbrSadRDDZJ7Rx4HaYkCK8pq1l-bUbf_4Nehin63F6mGCYt4033h9qA08J6E-bJz6LipG445qyuWaZW_6Hymicpg9fG5viTgnd_N_rY4cPvZ2C9APvg5q-6ctNeR5HZKx_2gmAxu0w82kgsLhNVVYnFNyIY8eCb6g7l1cxM</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Olorunnisola, Olubukola</creator><creator>Adetutu, Adewale</creator><creator>Afolayan, Anthony</creator><creator>Owoade, Abiodun</creator><general>Wolters Kluwer India Pvt. Ltd</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Sage Publications Ltd</general><general>Medknow Publications & Media Pvt Ltd</general><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161001</creationdate><title>Effect of methanolic leaf extract of Talinum triangulare (Jacq). willd. on biochemical parameters in diet induced dyslipidemia wistar rats</title><author>Olorunnisola, Olubukola ; Adetutu, Adewale ; Afolayan, Anthony ; Owoade, Abiodun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g500l-c700286e47b3dac420af5fea522c0fa8dbb1b7bd591cc17dad5f83889722b8ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antioxidants</topic><topic>Atherosclerosis</topic><topic>Biosynthesis</topic><topic>Blood platelets</topic><topic>Caryophyllidae</topic><topic>Cholesterol</topic><topic>Colleges & universities</topic><topic>Conflicts of interest</topic><topic>Drug dosages</topic><topic>Free radicals</topic><topic>Genetically modified mice</topic><topic>Health aspects</topic><topic>Hematology</topic><topic>Hypercholesterolemia</topic><topic>Laboratory animals</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Original</topic><topic>Oxidative stress</topic><topic>Plant extracts</topic><topic>Prevention</topic><topic>Rodents</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olorunnisola, Olubukola</creatorcontrib><creatorcontrib>Adetutu, Adewale</creatorcontrib><creatorcontrib>Afolayan, Anthony</creatorcontrib><creatorcontrib>Owoade, Abiodun</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pharmacognosy Magazine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olorunnisola, Olubukola</au><au>Adetutu, Adewale</au><au>Afolayan, Anthony</au><au>Owoade, Abiodun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of methanolic leaf extract of Talinum triangulare (Jacq). willd. on biochemical parameters in diet induced dyslipidemia wistar rats</atitle><jtitle>Pharmacognosy Magazine</jtitle><addtitle>Pharmacogn Mag</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>12</volume><issue>48</issue><spage>333</spage><epage>339</epage><pages>333-339</pages><issn>0973-1296</issn><eissn>0976-4062</eissn><abstract>Objective: To investigate the effect of methanolic leaf extract of Talinum triangulare on hematological parameters, enzymatic and non-enzymatic antioxidant status,and serum lipid in Wistar rats fed standard laboratory, or 2% cholesterol-enrich diet. Material and Methods: Wistar rats (180-210g) divided into six groups of six animals (males) each were fed 2% cholesterol-enriched diet and orally treated with 0.9% saline or extract of Talinum triangulare (250, 500, and 1000 mg/kg per body weight) daily for eight weeks. Lipid profile, lipid peroxidation (MDA), hematological parameters, and their functional indices and serum antioxidant enzymes (catalase, glutathione -S-transferase, and superoxide dismutase) activities and glutathione status were assessed in normal and diet-induced hypercholesterolemic extract treated rats and compared with the rats treated with 100 mg/kg per bwt standard drug gemfibrozil. Results: A significant (P < 0.05) increase in lipid profile (total glyceride, total cholestrol, low-density lipoprotein, and very low-density lipoprotein), MDA and reduction (P < 0.05) in enzymatic and nonenzymatic antioxidant status coupled with alterations in hematological parameters was observed in the serum of hypercholesterolemic rats when compared with animals on a normal diet. Coadministration of methanolic leaf extracts of Talinum triangulare or gemfibrozil significantly (P < 0.05) restored the elevated serum lipid profile, MDA, and the deranged hematological parameters to near normal. The extract also protected against hypercholesterolemic-induced diminished enzymatic and nonenzymatic antioxidant status. The activities of the plant extract are dose (250, 500, and 1000 mg/kg) dependent and it compared favorably with the standard drug gemfibrozil. Conclusion: The present study suggested that the extract of Talinum triangulare might protect against hypercholesterolemic-induced altered lipid profiles, oxidative stress, and also improve the status of antioxidant defense system and hematopoiesis.
Abbreviation used: Lipid peroxidation (MDA), (catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), glutathione (GSH), Thrombocytes indices (PLT), Red blood cell (RBC), Packed cell volume (PVC), Mean corpuscular hemoglobin(MCH), Mean corpuscular hemoglobin concentration (MCHC), Total glyceride (TG), Very low density lipoprotein (VLDL), Total cholesterol (TC), Low density lipoprotein (LDL), High density lipoprotein (HDL) and 3-Hydroxy-3-methyl-glutaryl-CoA reductase(HMG-CoA).</abstract><cop>United States</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>27867278</pmid><doi>10.4103/0973-1296.192194</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Atherosclerosis Biosynthesis Blood platelets Caryophyllidae Cholesterol Colleges & universities Conflicts of interest Drug dosages Free radicals Genetically modified mice Health aspects Hematology Hypercholesterolemia Laboratory animals Lipid peroxidation Lipids Lipoproteins Original Oxidative stress Plant extracts Prevention Rodents Thrombosis |
| title | Effect of methanolic leaf extract of Talinum triangulare (Jacq). willd. on biochemical parameters in diet induced dyslipidemia wistar rats |
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