A Cytochrome P450-Mediated Intramolecular Carbon-Carbon Ring Closure in the Biosynthesis of Multidrug-Resistance-Reversing Lathyrane Diterpenoids

The Euphorbiaceae produce a wide variety of bioactive diterpenoids. These include the lathyranes, which have received much interest due to their ability to inhibit the ABC transporters responsible for the loss of efficacy of many chemotherapy drugs. The lathyranes are also intermediates in the biosy...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2016-09, Vol.17 (17), p.1593-1597
Hauptverfasser:	King, Andrew J., Brown, Geoffrey D., Gilday, Alison D., Forestier, Edith, Larson, Tony R., Graham, Ian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - biosynthesis Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biosynthesis Carbon Carbon - chemistry Carbon - metabolism casbene Communication Communications Cytochrome Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytochromes Diterpenes - chemistry Diterpenes - metabolism Diterpenes - pharmacology diterpenoids Drug Resistance, Multiple - drug effects Drug Resistance, Neoplasm - drug effects Euphorbiaceae gene clusters Human immunodeficiency virus Jatropha - chemistry Jatropha curcas lathyranes Molecular Structure
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