FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome

Breast cancer (BC) is a heterogeneous disease, and different tumor characteristics and genetic variation may affect the clinical outcome. The FANCM c.5101C > T nonsense mutation in the Finnish population associates with increased risk of breast cancer, especially for triple‐negative breast cancer...

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Veröffentlicht in:	International journal of cancer 2016-12, Vol.139 (12), p.2760-2770
Hauptverfasser:	Kiiski, Johanna I., Fagerholm, Rainer, Tervasmäki, Anna, Pelttari, Liisa M., Khan, Sofia, Jamshidi, Maral, Mantere, Tuomo, Pylkäs, Katri, Bartek, Jiri, Bartkova, Jirina, Mannermaa, Arto, Tengström, Maria, Kosma, Veli‐Matti, Winqvist, Robert, Kallioniemi, Anne, Aittomäki, Kristiina, Blomqvist, Carl, Nevanlinna, Heli
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - therapy Cancer Cancer Genetics and Epigenetics Combined Modality Therapy DNA Helicases - genetics DNA Helicases - metabolism DNA repair FANCM Female Genotype Humans Kaplan-Meier Estimate Medical research Middle Aged Mortality Mutation Neoplasm Grading Neoplasm Metastasis Neoplasm Staging Phenotype Point Mutation Population Surveillance Prognosis Proportional Hazards Models radiotherapy survival Treatment Outcome Young Adult
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