Association of LRRK2 R1628P variant with Parkinson’s disease in Ethnic Han-Chinese and subgroup population
Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). The R1628P variant of LRRK2 may be a specific risk factor for PD in ethnic Han-Chinese populations. This study is to elucidate the epidemiological featur...
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| Veröffentlicht in: | Scientific reports 2016-11, Vol.6 (1), p.35171-35171, Article 35171 |
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| description | Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). The R1628P variant of LRRK2 may be a specific risk factor for PD in ethnic Han-Chinese populations. This study is to elucidate the epidemiological feature of R1628P in ethnic Han-Chinese population with PD. A comprehensive meta-analysis was performed to evaluate the precise association between R1628P variant and the risk for PD in ethnic Han-Chinese and subgroups stratified by gender, onset age, or family history. The analysis assessing the role of R1628P on the risk of PD in ethnic Han-Chinese supported a significant association, and the odds ratio was 1.86. We further estimate the specific prevalence in relevant ethnic Han-Chinese subgroups. After stratifying the eligible data by gender, onset age, or family history, significant associations were found in all male, female, early-onset, late-onset, familial and sporadic subgroups, and the odds ratio were 1.90, 1.94, 2.12, 1.75, 6.71 and 1.81 respectively. In conclusion, our meta-analysis suggests that R1628P variant of LRRK2 has a significant association with the risk of PD in ethnic Han-Chinese and subgroup population. |
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The R1628P variant of LRRK2 may be a specific risk factor for PD in ethnic Han-Chinese populations. This study is to elucidate the epidemiological feature of R1628P in ethnic Han-Chinese population with PD. A comprehensive meta-analysis was performed to evaluate the precise association between R1628P variant and the risk for PD in ethnic Han-Chinese and subgroups stratified by gender, onset age, or family history. The analysis assessing the role of R1628P on the risk of PD in ethnic Han-Chinese supported a significant association, and the odds ratio was 1.86. We further estimate the specific prevalence in relevant ethnic Han-Chinese subgroups. After stratifying the eligible data by gender, onset age, or family history, significant associations were found in all male, female, early-onset, late-onset, familial and sporadic subgroups, and the odds ratio were 1.90, 1.94, 2.12, 1.75, 6.71 and 1.81 respectively. In conclusion, our meta-analysis suggests that R1628P variant of LRRK2 has a significant association with the risk of PD in ethnic Han-Chinese and subgroup population.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep35171</identifier><identifier>PMID: 27812003</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/77 ; 631/378/1689 ; 631/378/2583 ; Age ; Family medical history ; Humanities and Social Sciences ; Kinases ; Leucine ; LRRK2 protein ; Movement disorders ; multidisciplinary ; Neurodegenerative diseases ; Parkinson's disease ; Population studies ; Science ; Single-nucleotide polymorphism</subject><ispartof>Scientific reports, 2016-11, Vol.6 (1), p.35171-35171, Article 35171</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Nov 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-29a97505f088bf73f548741b3ceb44befff53d517e2dc408b3bbac91c7b950c23</citedby><cites>FETCH-LOGICAL-c438t-29a97505f088bf73f548741b3ceb44befff53d517e2dc408b3bbac91c7b950c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095708/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095708/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27812003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Pei</creatorcontrib><creatorcontrib>Wang, Qingzhi</creatorcontrib><creatorcontrib>Jiao, Fengjuan</creatorcontrib><creatorcontrib>Yan, Jianguo</creatorcontrib><creatorcontrib>Chen, Lijun</creatorcontrib><creatorcontrib>He, Feng</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Tian, Bo</creatorcontrib><title>Association of LRRK2 R1628P variant with Parkinson’s disease in Ethnic Han-Chinese and subgroup population</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). The R1628P variant of LRRK2 may be a specific risk factor for PD in ethnic Han-Chinese populations. This study is to elucidate the epidemiological feature of R1628P in ethnic Han-Chinese population with PD. A comprehensive meta-analysis was performed to evaluate the precise association between R1628P variant and the risk for PD in ethnic Han-Chinese and subgroups stratified by gender, onset age, or family history. The analysis assessing the role of R1628P on the risk of PD in ethnic Han-Chinese supported a significant association, and the odds ratio was 1.86. We further estimate the specific prevalence in relevant ethnic Han-Chinese subgroups. After stratifying the eligible data by gender, onset age, or family history, significant associations were found in all male, female, early-onset, late-onset, familial and sporadic subgroups, and the odds ratio were 1.90, 1.94, 2.12, 1.75, 6.71 and 1.81 respectively. In conclusion, our meta-analysis suggests that R1628P variant of LRRK2 has a significant association with the risk of PD in ethnic Han-Chinese and subgroup population.</description><subject>45/77</subject><subject>631/378/1689</subject><subject>631/378/2583</subject><subject>Age</subject><subject>Family medical history</subject><subject>Humanities and Social Sciences</subject><subject>Kinases</subject><subject>Leucine</subject><subject>LRRK2 protein</subject><subject>Movement disorders</subject><subject>multidisciplinary</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson's disease</subject><subject>Population studies</subject><subject>Science</subject><subject>Single-nucleotide polymorphism</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNplkd9qFDEUxkNR2lJ74QuUQG9UGM2fSZPcCGWpVlywLHodkkyym3Y2GZOZine-Rl-vT2Lq1mWr5yaHnB_f-Q4fAC8xeosRFe9KdgNlmOM9cEhQyxpCCXm20x-A41KuUS1GZIvlPjggXGCCED0E_XkpyQY9hhRh8nC-WHwmcIHPiLiCtzoHHUf4I4wreKXzTYglxftfdwV2oThdHAwRXoyrGCy81LGZrUJ09VfHDpbJLHOaBjikYer_LHgBnnvdF3f8-B6Bbx8uvs4um_mXj59m5_PGtlSMDZFacoaYR0IYz6lnreAtNtQ607bGee8Z7erJjnS2RcJQY7SV2HIjGbKEHoH3G91hMmvXWRfHrHs15LDW-adKOqinkxhWapluFUOScSSqwKtHgZy-T66Mah2KdX2vo0tTUVjQM06xIKyip_-g12nKsZ5XKSkpRZQ_OHq9oWxOpSbmt2YwUg8xqm2MlT3Zdb8l_4ZWgTcboNRRXLq8s_I_td_g8afL</recordid><startdate>20161104</startdate><enddate>20161104</enddate><creator>Zhang, Pei</creator><creator>Wang, Qingzhi</creator><creator>Jiao, Fengjuan</creator><creator>Yan, Jianguo</creator><creator>Chen, Lijun</creator><creator>He, Feng</creator><creator>Zhang, Qian</creator><creator>Tian, Bo</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161104</creationdate><title>Association of LRRK2 R1628P variant with Parkinson’s disease in Ethnic Han-Chinese and subgroup population</title><author>Zhang, Pei ; Wang, Qingzhi ; Jiao, Fengjuan ; Yan, Jianguo ; Chen, Lijun ; He, Feng ; Zhang, Qian ; Tian, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-29a97505f088bf73f548741b3ceb44befff53d517e2dc408b3bbac91c7b950c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>45/77</topic><topic>631/378/1689</topic><topic>631/378/2583</topic><topic>Age</topic><topic>Family medical history</topic><topic>Humanities and Social Sciences</topic><topic>Kinases</topic><topic>Leucine</topic><topic>LRRK2 protein</topic><topic>Movement disorders</topic><topic>multidisciplinary</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson's disease</topic><topic>Population studies</topic><topic>Science</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Pei</creatorcontrib><creatorcontrib>Wang, Qingzhi</creatorcontrib><creatorcontrib>Jiao, Fengjuan</creatorcontrib><creatorcontrib>Yan, Jianguo</creatorcontrib><creatorcontrib>Chen, Lijun</creatorcontrib><creatorcontrib>He, Feng</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Tian, Bo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Pei</au><au>Wang, Qingzhi</au><au>Jiao, Fengjuan</au><au>Yan, Jianguo</au><au>Chen, Lijun</au><au>He, Feng</au><au>Zhang, Qian</au><au>Tian, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of LRRK2 R1628P variant with Parkinson’s disease in Ethnic Han-Chinese and subgroup population</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-11-04</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>35171</spage><epage>35171</epage><pages>35171-35171</pages><artnum>35171</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). The R1628P variant of LRRK2 may be a specific risk factor for PD in ethnic Han-Chinese populations. This study is to elucidate the epidemiological feature of R1628P in ethnic Han-Chinese population with PD. A comprehensive meta-analysis was performed to evaluate the precise association between R1628P variant and the risk for PD in ethnic Han-Chinese and subgroups stratified by gender, onset age, or family history. The analysis assessing the role of R1628P on the risk of PD in ethnic Han-Chinese supported a significant association, and the odds ratio was 1.86. We further estimate the specific prevalence in relevant ethnic Han-Chinese subgroups. After stratifying the eligible data by gender, onset age, or family history, significant associations were found in all male, female, early-onset, late-onset, familial and sporadic subgroups, and the odds ratio were 1.90, 1.94, 2.12, 1.75, 6.71 and 1.81 respectively. In conclusion, our meta-analysis suggests that R1628P variant of LRRK2 has a significant association with the risk of PD in ethnic Han-Chinese and subgroup population.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27812003</pmid><doi>10.1038/srep35171</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 45/77 631/378/1689 631/378/2583 Age Family medical history Humanities and Social Sciences Kinases Leucine LRRK2 protein Movement disorders multidisciplinary Neurodegenerative diseases Parkinson's disease Population studies Science Single-nucleotide polymorphism |
| title | Association of LRRK2 R1628P variant with Parkinson’s disease in Ethnic Han-Chinese and subgroup population |
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