Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues

Imaging mass cytometry was used for direct visualization of platinum localization in tissue sections from tumor and normal tissues of cisplatin-treated mice bearing pancreas cancer patient-derived xenografts. This recently-developed technology enabled simultaneous detection of multiple markers to de...

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Veröffentlicht in:	Scientific reports 2016-11, Vol.6 (1), p.36641-36641, Article 36641
Hauptverfasser:	Chang, Qing, Ornatsky, Olga I., Siddiqui, Iram, Straus, Rita, Baranov, Vladimir I., Hedley, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/51 631/1647/245 692/308/575 Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Biodistribution Biological activity Cancer Cell lineage Cell proliferation Cisplatin Cisplatin - metabolism Cisplatin - pharmacokinetics Cisplatin - therapeutic use Collagen Collagen - metabolism Cytometry Dimensional analysis DNA damage Drug dosages Fibers Humanities and Social Sciences Humans Hypoxia Localization Mice Mice, SCID multidisciplinary Pancreas Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Platinum Science Small intestine Stroma Tissue Distribution Tissues Tumors Xenograft Model Antitumor Assays Xenografts
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