Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients
The POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) was reported to be associated with tumor progression and metastasis. The purpose of this study was to evaluate the prognostic value of Pit-1 in breast cancer patients. The relative expression levels of Pit-1 in breast canc...
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| Veröffentlicht in: | Medical science monitor 2016-10, Vol.22, p.4121-4125 |
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| creator | Gao, Zhongcheng Xue, Kecheng Zhang, Lianfang Wei, Meng |
| description | The POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) was reported to be associated with tumor progression and metastasis. The purpose of this study was to evaluate the prognostic value of Pit-1 in breast cancer patients.
The relative expression levels of Pit-1 in breast cancer patients were detected by quantitative real-time PCR (qRT-PCR). Chi-square analysis was used to analyze the association between Pit-1 expression and clinical features. The Kaplan-Meier method was used to estimate the overall survival of the patients and Cox regression analysis was used to analyze the prognostic value of Pit-1.
Increased expression of Pit-1 was detected in the tumor tissues compared with the normal tissues (1.086 vs. 0.541) and the abnormal expression was associated with tumor size, clinical stage, tumor grade, and lymph node metastasis (P |
| doi_str_mv | 10.12659/MSM.896107 |
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The relative expression levels of Pit-1 in breast cancer patients were detected by quantitative real-time PCR (qRT-PCR). Chi-square analysis was used to analyze the association between Pit-1 expression and clinical features. The Kaplan-Meier method was used to estimate the overall survival of the patients and Cox regression analysis was used to analyze the prognostic value of Pit-1.
Increased expression of Pit-1 was detected in the tumor tissues compared with the normal tissues (1.086 vs. 0.541) and the abnormal expression was associated with tumor size, clinical stage, tumor grade, and lymph node metastasis (P<0.05). High expression level of Pit-1 was significantly associated with poor overall survival of the patients (P=0.001) and Cox regression analysis indicated that Pit-1 might be a prognostic factor for breast cancer prognosis (HR=1.955, 95% CI=1.295-3.035, P=0.003).
Pit-1 may be a potential prognostic biomarker for breast cancer patients and it is associated with tumor progression.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.896107</identifier><identifier>PMID: 27798557</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; China ; Clinical Research ; Disease-Free Survival ; Female ; Genes, Homeobox ; Humans ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Middle Aged ; Predictive Value of Tests ; Prognosis ; RNA, Messenger - metabolism ; Transcription Factor Pit-1 - biosynthesis ; Transcription Factor Pit-1 - genetics ; Transcription Factor Pit-1 - metabolism</subject><ispartof>Medical science monitor, 2016-10, Vol.22, p.4121-4125</ispartof><rights>Med Sci Monit, 2016 2016</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-181c0c80b932e1b72f54d655935b0790aa32ed7052f417d6533fd63bdbc6e2463</citedby><cites>FETCH-LOGICAL-c381t-181c0c80b932e1b72f54d655935b0790aa32ed7052f417d6533fd63bdbc6e2463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094475/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094475/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27798557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Zhongcheng</creatorcontrib><creatorcontrib>Xue, Kecheng</creatorcontrib><creatorcontrib>Zhang, Lianfang</creatorcontrib><creatorcontrib>Wei, Meng</creatorcontrib><title>Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>The POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) was reported to be associated with tumor progression and metastasis. The purpose of this study was to evaluate the prognostic value of Pit-1 in breast cancer patients.
The relative expression levels of Pit-1 in breast cancer patients were detected by quantitative real-time PCR (qRT-PCR). Chi-square analysis was used to analyze the association between Pit-1 expression and clinical features. The Kaplan-Meier method was used to estimate the overall survival of the patients and Cox regression analysis was used to analyze the prognostic value of Pit-1.
Increased expression of Pit-1 was detected in the tumor tissues compared with the normal tissues (1.086 vs. 0.541) and the abnormal expression was associated with tumor size, clinical stage, tumor grade, and lymph node metastasis (P<0.05). High expression level of Pit-1 was significantly associated with poor overall survival of the patients (P=0.001) and Cox regression analysis indicated that Pit-1 might be a prognostic factor for breast cancer prognosis (HR=1.955, 95% CI=1.295-3.035, P=0.003).
Pit-1 may be a potential prognostic biomarker for breast cancer patients and it is associated with tumor progression.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>China</subject><subject>Clinical Research</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Genes, Homeobox</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphatic Metastasis</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription Factor Pit-1 - biosynthesis</subject><subject>Transcription Factor Pit-1 - genetics</subject><subject>Transcription Factor Pit-1 - metabolism</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkcFLwzAUxoMoTqcn75KjItWkaZr2IujYnKCsoDuHNE1npGtmXje2_97oVOYpL-_78b3H-xA6o-SaxinPb55fnq-zPKVE7KEjmiYsYoKT_Z26h44B3gmJs5TwQ9SLhcgzzsUR2kxWxkfD9cIbAOta7GpcTKZ40CgATPHYzY0r3TqUr161oL1ddF_cSOnOeXxR2C6il7jwprK6A1y40C28m7UOLOA6_O69UdDhgWq1CZrqrGk7OEEHtWrAnP68fTQdDV8H4-hp8vA4uHuKNMto8M6oJjojZc5iQ0sR1zypUs5zxksicqJU6FeC8LhOqAgKY3WVsrIqdWriJGV9dLv1XSzLual0mO1VIxfezpXfSKes_K-09k3O3EpykieJ4MHg4sfAu4-lgU7OLWjTNKo1bgmSZizJwzlFFtCrLaq9A_Cm_htDifwOS4aw5DasQJ_vbvbH_qbDPgEGNI_C</recordid><startdate>20161031</startdate><enddate>20161031</enddate><creator>Gao, Zhongcheng</creator><creator>Xue, Kecheng</creator><creator>Zhang, Lianfang</creator><creator>Wei, Meng</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161031</creationdate><title>Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients</title><author>Gao, Zhongcheng ; Xue, Kecheng ; Zhang, Lianfang ; Wei, Meng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-181c0c80b932e1b72f54d655935b0790aa32ed7052f417d6533fd63bdbc6e2463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>China</topic><topic>Clinical Research</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Genes, Homeobox</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphatic Metastasis</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription Factor Pit-1 - biosynthesis</topic><topic>Transcription Factor Pit-1 - genetics</topic><topic>Transcription Factor Pit-1 - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Gao, Zhongcheng</creatorcontrib><creatorcontrib>Xue, Kecheng</creatorcontrib><creatorcontrib>Zhang, Lianfang</creatorcontrib><creatorcontrib>Wei, Meng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Zhongcheng</au><au>Xue, Kecheng</au><au>Zhang, Lianfang</au><au>Wei, Meng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2016-10-31</date><risdate>2016</risdate><volume>22</volume><spage>4121</spage><epage>4125</epage><pages>4121-4125</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>The POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) was reported to be associated with tumor progression and metastasis. The purpose of this study was to evaluate the prognostic value of Pit-1 in breast cancer patients.
The relative expression levels of Pit-1 in breast cancer patients were detected by quantitative real-time PCR (qRT-PCR). Chi-square analysis was used to analyze the association between Pit-1 expression and clinical features. The Kaplan-Meier method was used to estimate the overall survival of the patients and Cox regression analysis was used to analyze the prognostic value of Pit-1.
Increased expression of Pit-1 was detected in the tumor tissues compared with the normal tissues (1.086 vs. 0.541) and the abnormal expression was associated with tumor size, clinical stage, tumor grade, and lymph node metastasis (P<0.05). High expression level of Pit-1 was significantly associated with poor overall survival of the patients (P=0.001) and Cox regression analysis indicated that Pit-1 might be a prognostic factor for breast cancer prognosis (HR=1.955, 95% CI=1.295-3.035, P=0.003).
Pit-1 may be a potential prognostic biomarker for breast cancer patients and it is associated with tumor progression.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>27798557</pmid><doi>10.12659/MSM.896107</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology China Clinical Research Disease-Free Survival Female Genes, Homeobox Humans Kaplan-Meier Estimate Lymphatic Metastasis Middle Aged Predictive Value of Tests Prognosis RNA, Messenger - metabolism Transcription Factor Pit-1 - biosynthesis Transcription Factor Pit-1 - genetics Transcription Factor Pit-1 - metabolism |
| title | Over-Expression of POU Class 1 Homeobox 1 Transcription Factor (Pit-1) Predicts Poor Prognosis for Breast Cancer Patients |
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