Down-Regulation of MicroRNA-133b Suppresses Apoptosis of Lens Epithelial Cell by Up-Regulating BCL2L2 in Age-Related Cataracts

BACKGROUND MicroRNA-133b (miR-133b) has been reported to be involved in many diseases, including ovarian cancer and osteosarcoma. Accumulating evidence suggests that miR-133b plays important roles in human disease. In this study, we aimed to investigate the molecular mechanism, including the potenti...

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Veröffentlicht in:	Medical science monitor 2016-11, Vol.22, p.4139-4145
Hauptverfasser:	Zhang, Feng, Meng, Weizhe, Tong, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Apoptosis - genetics Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Cataract - genetics Cataract - metabolism Cell Line, Tumor Cell Proliferation - genetics Down-Regulation Epithelial Cells - metabolism Female Humans Lab/In Vitro Research Lens, Crystalline - metabolism Male MicroRNAs - genetics MicroRNAs - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics Signal Transduction Up-Regulation
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