Efficacy of naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy: study protocol for a double-blind, randomized, placebo-controlled trial

Generalized tonic-clonic seizures (GTCSs) are the main risk factor for sudden unexpected death in epilepsy (SUDEP). Experimental and clinical data strongly suggest that the majority of SUDEP results from a postictal respiratory dysfunction progressing to terminal apnea. Postictal apnea could partly...

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Veröffentlicht in:	Current controlled trials in cardiovascular medicine 2016-11, Vol.17 (1), p.529-529, Article 529
Hauptverfasser:	Rheims, Sylvain, Valton, Luc, Michel, Véronique, Maillard, Louis, Navarro, Vincent, Convers, Philippe, Bartolomei, Fabrice, Biraben, Arnaud, Crespel, Arielle, Derambure, Philippe, de Toffol, Bertrand, Hirsch, Edouard, Kahane, Philippe, Martin, Martine Lemesle, Tourniaire, Didier, Boulogne, Sébastien, Mercier, Catherine, Roy, Pascal, Ryvlin, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical Protocols Convulsions & seizures Double-Blind Method Double-blind studies Drug Administration Schedule Drug overdose Drug resistance Electroencephalography Electroencephalography - methods Epilepsy France Humans Hypotheses Hypoxemia Hypoxia - etiology Hypoxia - physiopathology Hypoxia - prevention & control Injections, Intravenous Life Sciences Medication Naloxone - administration & dosage Naloxone - adverse effects Narcotic Antagonists - administration & dosage Narcotic Antagonists - adverse effects Narcotics Neurobiology Neurons and Cognition Oxygen saturation Patients Pharmaceutical sciences Pharmaceuticals Pulse oximetry Research Design Respiratory Center - drug effects Respiratory Center - physiopathology Respiratory Insufficiency - diagnosis Respiratory Insufficiency - etiology Respiratory Insufficiency - physiopathology Respiratory Insufficiency - prevention & control Seizures - complications Seizures - diagnosis Seizures - drug therapy Seizures - physiopathology Severity of Illness Index Study Protocol Time Factors Treatment Outcome Young adults
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