Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis

Objective Genetic variation in FOXO3 (tagged by rs12212067) has been associated with a milder course of rheumatoid arthritis (RA) and shown to limit monocyte‐driven inflammation through a transforming growth factor β1–dependent pathway. This genetic association, however, has not been consistently ob...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2016-11, Vol.68 (11), p.2629-2636
Hauptverfasser:	Viatte, Sebastien, Lee, James C., Fu, Bo, Espéli, Marion, Lunt, Mark, De Wolf, Jack N. E., Wheeler, Lily, Reynolds, John A., Castelino, Madhura, Symmons, Deborah P. M., Lyons, Paul A., Barton, Anne, Smith, Kenneth G. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Arthritis Arthritis - genetics Arthritis - immunology Arthritis - physiopathology Arthritis, Experimental - genetics Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Experimental - physiopathology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - physiopathology C-Reactive Protein - immunology Cohort Studies Female Forkhead Box Protein O3 - genetics Humans Inflammation Longitudinal Studies Male Mice Mice, Knockout Middle Aged Mutation Polymorphism, Single Nucleotide Prospective Studies Rheumatoid Arthritis Severity of Illness Index
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