Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2

Thromboxane A2 (TXA2) is a labile metabolite of arachidonic acid that has potent biological effects. Its actions are mediated by G protein-coupled thromboxane-prostanoid (TP) receptors. TP receptors have been implicated in the pathogenesis of cardiovascular diseases. To investigate the physiological...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 1998-12, Vol.102 (11), p.1994-2001
Hauptverfasser:	Thomas, D W, Mannon, R B, Mannon, P J, Latour, A, Oliver, J A, Hoffman, M, Smithies, O, Koller, B H, Coffman, T M
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Adenosine Diphosphate - pharmacology Animals Arachidonic Acid - toxicity Bleeding Time Blood Coagulation Disorders - etiology Blood Coagulation Disorders - genetics Collagen - pharmacology Female Hemodynamics - physiology Male Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Receptors, Thromboxane - antagonists & inhibitors Receptors, Thromboxane - deficiency Receptors, Thromboxane - genetics Receptors, Thromboxane - physiology Shock - chemically induced Thromboxane A2 - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!