Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice

Graft-versus-host disease (GVHD), in which immunocompetent donor cells attack the host, remains a major cause of morbidity after allogeneic bone marrow transplantation (BMT). To understand the role of cytokines in the pathobiology of GVHD, we used cytokine knockout (KO) mice as a source of donor T c...

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Veröffentlicht in:	The Journal of clinical investigation 1998-11, Vol.102 (9), p.1742-1748
Hauptverfasser:	Murphy, W J, Welniak, L A, Taub, D D, Wiltrout, R H, Taylor, P A, Vallera, D A, Kopf, M, Young, H, Longo, D L, Blazar, B R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Transplantation - immunology Cell Division Concanavalin A - pharmacology Graft vs Host Disease - immunology Interferon-gamma - immunology Interleukin-2 - biosynthesis Interleukin-4 - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mitogens - pharmacology Spleen - cytology Transplantation, Homologous
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