Regulation of acetylcholine receptor gene expression in human myasthenia gravis muscles. Evidences for a compensatory mechanism triggered by receptor loss

Myasthenia gravis (MG) is a neuromuscular disorder mediated by antibodies directed against the acetylcholine receptor (nAChR) resulting in a functional nAChR loss. To analyze the molecular mechanisms involved at the muscular target site, we studied the expression of nAChR subunits in muscle biopsy s...

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Veröffentlicht in:	The Journal of clinical investigation 1998-07, Vol.102 (1), p.249-263
Hauptverfasser:	Guyon, T, Wakkach, A, Poea, S, Mouly, V, Klingel-Schmitt, I, Levasseur, P, Beeson, D, Asher, O, Tzartos, S, Berrih-Aknin, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Cell Line Disease Models, Animal Female Gene Expression Regulation Humans Male Middle Aged Muscles - metabolism Myasthenia Gravis - metabolism Receptors, Nicotinic - genetics RNA, Messenger - analysis Transcription, Genetic
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