Particulate Matter and Subclinical Atherosclerosis: Associations between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the SAPALDIA Study
Subclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources of exposure remains unclear. We investigated the association of long-term exposure to PM10 (≤ 10 μm), PM2.5 (≤ 2.5 μm: total mass, vehicular, and crustal...
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creator | Aguilera, Inmaculada Dratva, Julia Caviezel, Seraina Burdet, Luc de Groot, Eric Ducret-Stich, Regina E Eeftens, Marloes Keidel, Dirk Meier, Reto Perez, Laura Rothe, Thomas Schaffner, Emmanuel Schmit-Trucksäss, Arno Tsai, Ming-Yi Schindler, Christian Künzli, Nino Probst-Hensch, Nicole |
description | Subclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources of exposure remains unclear.
We investigated the association of long-term exposure to PM10 (≤ 10 μm), PM2.5 (≤ 2.5 μm: total mass, vehicular, and crustal sources), and ultrafine particles [UFP < 0.1 μm: particle number concentration (PNC) and lung-deposited surface area (LDSA)] with carotid intima-media thickness (CIMT).
We used data from 1,503 participants ≥ 50 years old who participated in the third examination of the Swiss SAPALDIA cohort. Exposures were obtained from dispersion models and land-use regression models. Covariate information, including previous cardiovascular risk factors, was obtained from the second and third SAPALDIA examinations.
The adjusted percent difference in CIMT associated with an exposure contrast between the 10th and 90th percentile was 1.58% (95% CI: -0.30, 3.47%) for PM10, 2.10% (95% CI: 0.04, 4.16%) for PM2.5, 1.67% (95% CI: -0.13, 3.48%) for the vehicular source of PM2.5, -0.58% (95% CI: -3.95, 2.79%) for the crustal source of PM2.5, 2.06% (95% CI: 0.03, 4.10%) for PNC, and 2.32% (95% CI: 0.23, 4.40%) for LDSA. Stronger associations were observed among diabetics, subjects with low-educational level, and those at higher cardiovascular risk.
CIMT was associated with exposure to PM10, PM2.5, and UFP. The PM2.5 source-specific analysis showed a positive association for the vehicular source but not for the crustal source. Although the effects of PNC and LDSA were similar in magnitude, two-pollutant and residual-based models suggested that LDSA may be a better marker for the health relevance of UFP. Citation: Aguilera I, Dratva J, Caviezel S, Burdet L, de Groot E, Ducret-Stich RE, Eeftens M, Keidel D, Meier R, Perez L, Rothe T, Schaffner E, Schmit-Trucksäss A, Tsai MY, Schindler C, Künzli N, Probst-Hensch N. 2016. Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study. Environ Health Perspect 124:1700-1706; http://dx.doi.org/10.1289/EHP161. |
doi_str_mv | 10.1289/EHP161 |
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We investigated the association of long-term exposure to PM10 (≤ 10 μm), PM2.5 (≤ 2.5 μm: total mass, vehicular, and crustal sources), and ultrafine particles [UFP < 0.1 μm: particle number concentration (PNC) and lung-deposited surface area (LDSA)] with carotid intima-media thickness (CIMT).
We used data from 1,503 participants ≥ 50 years old who participated in the third examination of the Swiss SAPALDIA cohort. Exposures were obtained from dispersion models and land-use regression models. Covariate information, including previous cardiovascular risk factors, was obtained from the second and third SAPALDIA examinations.
The adjusted percent difference in CIMT associated with an exposure contrast between the 10th and 90th percentile was 1.58% (95% CI: -0.30, 3.47%) for PM10, 2.10% (95% CI: 0.04, 4.16%) for PM2.5, 1.67% (95% CI: -0.13, 3.48%) for the vehicular source of PM2.5, -0.58% (95% CI: -3.95, 2.79%) for the crustal source of PM2.5, 2.06% (95% CI: 0.03, 4.10%) for PNC, and 2.32% (95% CI: 0.23, 4.40%) for LDSA. Stronger associations were observed among diabetics, subjects with low-educational level, and those at higher cardiovascular risk.
CIMT was associated with exposure to PM10, PM2.5, and UFP. The PM2.5 source-specific analysis showed a positive association for the vehicular source but not for the crustal source. Although the effects of PNC and LDSA were similar in magnitude, two-pollutant and residual-based models suggested that LDSA may be a better marker for the health relevance of UFP. Citation: Aguilera I, Dratva J, Caviezel S, Burdet L, de Groot E, Ducret-Stich RE, Eeftens M, Keidel D, Meier R, Perez L, Rothe T, Schaffner E, Schmit-Trucksäss A, Tsai MY, Schindler C, Künzli N, Probst-Hensch N. 2016. Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study. Environ Health Perspect 124:1700-1706; http://dx.doi.org/10.1289/EHP161.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/EHP161</identifier><identifier>PMID: 27258721</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Aged ; Aged, 80 and over ; Atherosclerosis ; Atherosclerosis - etiology ; Carotid artery ; Carotid Intima-Media Thickness ; Cohort Studies ; Educational Status ; Environmental Exposure ; Female ; Health aspects ; Humans ; Male ; Middle Aged ; Particle Size ; Particles ; Particulate Matter - analysis ; Particulate Matter - chemistry ; Particulate Matter - toxicity ; Switzerland</subject><ispartof>Environmental health perspectives, 2016-11, Vol.124 (11), p.1700-1706</ispartof><rights>COPYRIGHT 2016 National Institute of Environmental Health Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-e61b9d5645bc378bceecbaa4c46cfa5a7235e056ddf01351084318cbea8ba59a3</citedby><cites>FETCH-LOGICAL-c570t-e61b9d5645bc378bceecbaa4c46cfa5a7235e056ddf01351084318cbea8ba59a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089877/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089877/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27258721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aguilera, Inmaculada</creatorcontrib><creatorcontrib>Dratva, Julia</creatorcontrib><creatorcontrib>Caviezel, Seraina</creatorcontrib><creatorcontrib>Burdet, Luc</creatorcontrib><creatorcontrib>de Groot, Eric</creatorcontrib><creatorcontrib>Ducret-Stich, Regina E</creatorcontrib><creatorcontrib>Eeftens, Marloes</creatorcontrib><creatorcontrib>Keidel, Dirk</creatorcontrib><creatorcontrib>Meier, Reto</creatorcontrib><creatorcontrib>Perez, Laura</creatorcontrib><creatorcontrib>Rothe, Thomas</creatorcontrib><creatorcontrib>Schaffner, Emmanuel</creatorcontrib><creatorcontrib>Schmit-Trucksäss, Arno</creatorcontrib><creatorcontrib>Tsai, Ming-Yi</creatorcontrib><creatorcontrib>Schindler, Christian</creatorcontrib><creatorcontrib>Künzli, Nino</creatorcontrib><creatorcontrib>Probst-Hensch, Nicole</creatorcontrib><title>Particulate Matter and Subclinical Atherosclerosis: Associations between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the SAPALDIA Study</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Subclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources of exposure remains unclear.
We investigated the association of long-term exposure to PM10 (≤ 10 μm), PM2.5 (≤ 2.5 μm: total mass, vehicular, and crustal sources), and ultrafine particles [UFP < 0.1 μm: particle number concentration (PNC) and lung-deposited surface area (LDSA)] with carotid intima-media thickness (CIMT).
We used data from 1,503 participants ≥ 50 years old who participated in the third examination of the Swiss SAPALDIA cohort. Exposures were obtained from dispersion models and land-use regression models. Covariate information, including previous cardiovascular risk factors, was obtained from the second and third SAPALDIA examinations.
The adjusted percent difference in CIMT associated with an exposure contrast between the 10th and 90th percentile was 1.58% (95% CI: -0.30, 3.47%) for PM10, 2.10% (95% CI: 0.04, 4.16%) for PM2.5, 1.67% (95% CI: -0.13, 3.48%) for the vehicular source of PM2.5, -0.58% (95% CI: -3.95, 2.79%) for the crustal source of PM2.5, 2.06% (95% CI: 0.03, 4.10%) for PNC, and 2.32% (95% CI: 0.23, 4.40%) for LDSA. Stronger associations were observed among diabetics, subjects with low-educational level, and those at higher cardiovascular risk.
CIMT was associated with exposure to PM10, PM2.5, and UFP. The PM2.5 source-specific analysis showed a positive association for the vehicular source but not for the crustal source. Although the effects of PNC and LDSA were similar in magnitude, two-pollutant and residual-based models suggested that LDSA may be a better marker for the health relevance of UFP. Citation: Aguilera I, Dratva J, Caviezel S, Burdet L, de Groot E, Ducret-Stich RE, Eeftens M, Keidel D, Meier R, Perez L, Rothe T, Schaffner E, Schmit-Trucksäss A, Tsai MY, Schindler C, Künzli N, Probst-Hensch N. 2016. Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study. Environ Health Perspect 124:1700-1706; http://dx.doi.org/10.1289/EHP161.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - etiology</subject><subject>Carotid artery</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cohort Studies</subject><subject>Educational Status</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Particle Size</subject><subject>Particles</subject><subject>Particulate Matter - analysis</subject><subject>Particulate Matter - chemistry</subject><subject>Particulate Matter - toxicity</subject><subject>Switzerland</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt9qFDEUxgdR7Fr1ESQgCF5MTWYm88eLwrCtdmFLF7d6G85kzuxEs0mZZKz1hXxNs46WLuyFBE7Cye98Jzl8UfSS0ROWlNW784sVy9mjaMY4T-KqSrLH0YzSisV5kfOj6JlzXymlrMzzp9FRUiS8LBI2i36tYPBKjho8kkvwHgcCpiXrsZFaGSVBk9r3OFgn9S4q957UzlmpwCtrHGnQ3yIacqa6Dgc0nkySGsla_UQ3ydlxkOF8q3xP5jBYr1qyMF5tIb7EVgG57pX8ZtA5ogwJDcm6XtXLs0VN1n5s755HTzrQDl_83Y-jzx_Or-cX8fLq42JeL2PJC-pjzFlTtTzPeCPTomwkomwAMpnlsgMORZJypDxv246ylDNaZikrZYNQNsArSI-j00n3Zmy22MrwnwG0uBnCS4c7YUGJ_RujerGx3wWnZVUWRRB4PQlsQKNQprMBk1vlpKizXbeUsh0VH6A2aDBoWoOdCuk9_uQAH1aLWyUPFrzdKwiMxx9-A6NzYrH-9P_s1Zd99s0DtkfQvndWj3-8cBCUwTRuwO5-hoyKnWXFZNkAvno48Xvsn0fT34U95kc</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Aguilera, Inmaculada</creator><creator>Dratva, Julia</creator><creator>Caviezel, Seraina</creator><creator>Burdet, Luc</creator><creator>de Groot, Eric</creator><creator>Ducret-Stich, Regina E</creator><creator>Eeftens, Marloes</creator><creator>Keidel, Dirk</creator><creator>Meier, Reto</creator><creator>Perez, Laura</creator><creator>Rothe, Thomas</creator><creator>Schaffner, Emmanuel</creator><creator>Schmit-Trucksäss, Arno</creator><creator>Tsai, Ming-Yi</creator><creator>Schindler, Christian</creator><creator>Künzli, Nino</creator><creator>Probst-Hensch, Nicole</creator><general>National Institute of Environmental Health Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>5PM</scope></search><sort><creationdate>20161101</creationdate><title>Particulate Matter and Subclinical Atherosclerosis: Associations between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the SAPALDIA Study</title><author>Aguilera, Inmaculada ; Dratva, Julia ; Caviezel, Seraina ; Burdet, Luc ; de Groot, Eric ; Ducret-Stich, Regina E ; Eeftens, Marloes ; Keidel, Dirk ; Meier, Reto ; Perez, Laura ; Rothe, Thomas ; Schaffner, Emmanuel ; Schmit-Trucksäss, Arno ; Tsai, Ming-Yi ; Schindler, Christian ; Künzli, Nino ; Probst-Hensch, Nicole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-e61b9d5645bc378bceecbaa4c46cfa5a7235e056ddf01351084318cbea8ba59a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - etiology</topic><topic>Carotid artery</topic><topic>Carotid Intima-Media Thickness</topic><topic>Cohort Studies</topic><topic>Educational Status</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Particle Size</topic><topic>Particles</topic><topic>Particulate Matter - analysis</topic><topic>Particulate Matter - chemistry</topic><topic>Particulate Matter - toxicity</topic><topic>Switzerland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aguilera, Inmaculada</creatorcontrib><creatorcontrib>Dratva, Julia</creatorcontrib><creatorcontrib>Caviezel, Seraina</creatorcontrib><creatorcontrib>Burdet, Luc</creatorcontrib><creatorcontrib>de Groot, Eric</creatorcontrib><creatorcontrib>Ducret-Stich, Regina E</creatorcontrib><creatorcontrib>Eeftens, Marloes</creatorcontrib><creatorcontrib>Keidel, Dirk</creatorcontrib><creatorcontrib>Meier, Reto</creatorcontrib><creatorcontrib>Perez, Laura</creatorcontrib><creatorcontrib>Rothe, Thomas</creatorcontrib><creatorcontrib>Schaffner, Emmanuel</creatorcontrib><creatorcontrib>Schmit-Trucksäss, Arno</creatorcontrib><creatorcontrib>Tsai, Ming-Yi</creatorcontrib><creatorcontrib>Schindler, Christian</creatorcontrib><creatorcontrib>Künzli, Nino</creatorcontrib><creatorcontrib>Probst-Hensch, Nicole</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aguilera, Inmaculada</au><au>Dratva, Julia</au><au>Caviezel, Seraina</au><au>Burdet, Luc</au><au>de Groot, Eric</au><au>Ducret-Stich, Regina E</au><au>Eeftens, Marloes</au><au>Keidel, Dirk</au><au>Meier, Reto</au><au>Perez, Laura</au><au>Rothe, Thomas</au><au>Schaffner, Emmanuel</au><au>Schmit-Trucksäss, Arno</au><au>Tsai, Ming-Yi</au><au>Schindler, Christian</au><au>Künzli, Nino</au><au>Probst-Hensch, Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Particulate Matter and Subclinical Atherosclerosis: Associations between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the SAPALDIA Study</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>124</volume><issue>11</issue><spage>1700</spage><epage>1706</epage><pages>1700-1706</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Subclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources of exposure remains unclear.
We investigated the association of long-term exposure to PM10 (≤ 10 μm), PM2.5 (≤ 2.5 μm: total mass, vehicular, and crustal sources), and ultrafine particles [UFP < 0.1 μm: particle number concentration (PNC) and lung-deposited surface area (LDSA)] with carotid intima-media thickness (CIMT).
We used data from 1,503 participants ≥ 50 years old who participated in the third examination of the Swiss SAPALDIA cohort. Exposures were obtained from dispersion models and land-use regression models. Covariate information, including previous cardiovascular risk factors, was obtained from the second and third SAPALDIA examinations.
The adjusted percent difference in CIMT associated with an exposure contrast between the 10th and 90th percentile was 1.58% (95% CI: -0.30, 3.47%) for PM10, 2.10% (95% CI: 0.04, 4.16%) for PM2.5, 1.67% (95% CI: -0.13, 3.48%) for the vehicular source of PM2.5, -0.58% (95% CI: -3.95, 2.79%) for the crustal source of PM2.5, 2.06% (95% CI: 0.03, 4.10%) for PNC, and 2.32% (95% CI: 0.23, 4.40%) for LDSA. Stronger associations were observed among diabetics, subjects with low-educational level, and those at higher cardiovascular risk.
CIMT was associated with exposure to PM10, PM2.5, and UFP. The PM2.5 source-specific analysis showed a positive association for the vehicular source but not for the crustal source. Although the effects of PNC and LDSA were similar in magnitude, two-pollutant and residual-based models suggested that LDSA may be a better marker for the health relevance of UFP. Citation: Aguilera I, Dratva J, Caviezel S, Burdet L, de Groot E, Ducret-Stich RE, Eeftens M, Keidel D, Meier R, Perez L, Rothe T, Schaffner E, Schmit-Trucksäss A, Tsai MY, Schindler C, Künzli N, Probst-Hensch N. 2016. Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study. Environ Health Perspect 124:1700-1706; http://dx.doi.org/10.1289/EHP161.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>27258721</pmid><doi>10.1289/EHP161</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aged, 80 and over Atherosclerosis Atherosclerosis - etiology Carotid artery Carotid Intima-Media Thickness Cohort Studies Educational Status Environmental Exposure Female Health aspects Humans Male Middle Aged Particle Size Particles Particulate Matter - analysis Particulate Matter - chemistry Particulate Matter - toxicity Switzerland |
title | Particulate Matter and Subclinical Atherosclerosis: Associations between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the SAPALDIA Study |
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