Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-β1/Smad3

The microRNA (miR)‐29 family is closely associated with fibrotic processes by virtue of its low expression in many tissues during organ fibrosis. The present study investigated whether miR‐29b overexpression suppressed hepatic stellate cell (HSC) activation and its interactions with transforming gro...

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Veröffentlicht in:	Cell biochemistry and function 2016-07, Vol.34 (5), p.326-333
Hauptverfasser:	Liang, Chunli, Bu, Shurui, Fan, Xiaoming
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Cell Proliferation Cells, Cultured Collagen Type I - metabolism crosstalk Gene Expression Regulation gene transfection hepatic stellate cell Hepatic Stellate Cells - cytology Hepatic Stellate Cells - metabolism Humans MicroRNAs - genetics MicroRNAs - metabolism miR-29b Signal Transduction Smad3 Protein - metabolism TGF-β1/Smad3 Transfection Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism
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