Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors

Liver fibrosis results from the excessive secretion of matrix proteins by hepatic stellate cells (HSC), which proliferate during fibrotic liver injury. We have studied a model of spontaneous recovery from liver fibrosis to determine the biological mechanisms mediating resolution. Livers were harvest...

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Veröffentlicht in:	The Journal of clinical investigation 1998-08, Vol.102 (3), p.538-549
Hauptverfasser:	Iredale, J P, Benyon, R C, Pickering, J, McCullen, M, Northrop, M, Pawley, S, Hovell, C, Arthur, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Carbon Tetrachloride - toxicity Chemical and Drug Induced Liver Injury - complications Collagenases - biosynthesis Collagenases - genetics Gene Expression Regulation Hydroxyproline - analysis Liver Cirrhosis, Experimental - enzymology Liver Cirrhosis, Experimental - pathology Male Matrix Metalloproteinase 1 Matrix Metalloproteinase 13 Matrix Metalloproteinase Inhibitors Procollagen - biosynthesis Procollagen - genetics Rats Rats, Sprague-Dawley Remission, Spontaneous RNA, Messenger - biosynthesis Tissue Inhibitor of Metalloproteinase-1 - biosynthesis Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Tissue Inhibitor of Metalloproteinase-2 - genetics
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