Immunomodulation by mucosal gene transfer using TGF-beta DNA

This report evaluates the efficacy of DNA encoding TGF-beta administered mucosally to suppress immunity and modulate the immunoinflammatory response to herpes simplex virus (HSV) infection. A single intranasal administration of an eukaryotic expression vector encoding TGF-beta1 led to expression in...

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Veröffentlicht in:	The Journal of clinical investigation 1998-07, Vol.102 (2), p.438-444
Hauptverfasser:	Kuklin, N A, Daheshia, M, Chun, S, Rouse, B T
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Cercopithecus aethiops Disease Models, Animal DNA - immunology Female Gene Expression Gene Transfer Techniques Herpes Simplex - immunology Herpes Simplex - pathology Herpes Simplex - prevention & control Humans Mice Mice, Inbred BALB C Nasal Mucosa Plasmids Transforming Growth Factor beta - genetics Transforming Growth Factor beta - pharmacology Vero Cells
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