Development of Novel Small Hairpin RNAs That do not Require Processing by Dicer or AGO2

The innate cytokine response to nucleic acid is the most challenging problem confronting the practical use of nucleic acid medicine. The degree of stimulation of the innate cytokine response strongly depends on the length of the nucleic acid. In this study, we developed a 30-nucleotide single-strand...

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Veröffentlicht in:	Molecular therapy 2016-08, Vol.24 (7), p.1278-1289
Hauptverfasser:	Ohno, Shin-ichiro, Itano, Karen, Harada, Yuichirou, Asada, Koutaro, Oikawa, Keiki, Kashiwazako, Mikie, Okuyama, Hikaru, Kumagai, Katsuyoshi, Takanashi, Masakatsu, Sudo, Katsuko, Ikeda, Norihiko, Kuroda, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Apoptosis Argonaute Proteins - genetics Argonaute Proteins - metabolism Base Pairing Base Sequence Cancer therapies Cell Line Cells CRISPR-Cas Systems Cytokines Disease Models, Animal Enzymes Gene Expression Gene Knockdown Techniques Genes Humans Kinases Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Mice MicroRNAs Nucleic Acid Conformation Original Physiology Protein Binding Protein expression Proteins Ribonuclease III - genetics Ribonuclease III - metabolism RNA, Guide, CRISPR-Cas Systems RNA, Messenger - genetics RNA, Small Interfering - chemistry RNA, Small Interfering - genetics RNA, Small Interfering - metabolism
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