NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis
Cutaneous leishmaniasis (CL) is endemic in Campeche state, Mexico. Host and parasite factors are involved in the establishment and development of CL. Host factors include immune response and genetic background. NRAMP1 (Natural Resistance Associated Macrophage Protein 1) is important in innate immuni...
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| Veröffentlicht in: | BioMed research international 2016-01, Vol.2016 (2016), p.1-8 |
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| creator | Cancino-Díaz, Mario E. Monroy-Ostria, Amalia Chiñas-Pérez, Adelaido Ramírez-Ramírez, Alicia Hernández-Rivera, Mirsha Pamela Hernández-Montes, Omar |
| description | Cutaneous leishmaniasis (CL) is endemic in Campeche state, Mexico. Host and parasite factors are involved in the establishment and development of CL. Host factors include immune response and genetic background. NRAMP1 (Natural Resistance Associated Macrophage Protein 1) is important in innate immunity. Polymorphisms in NRAMP1 have been associated with susceptibility or resistance to infectious and autoimmune diseases. To study the association of NRAMP1 mutations with CL in patients from Calakmul, Campeche, samples from 115 CL patients and 69 samples of healthy people from the same area were evaluated. Five regions in NRAMP1 were amplified and digested, looking for mutations in the promoter region (−524G/C), exon 3 (274C/T), exon 8 (823 C7T), and exon 15 (G/A) and deletion of 4 bp in the 3′UTR region. We found a statistical association between polymorphisms in 3′UTR region and exon 8 and CL [χ2=13.26; p |
| doi_str_mv | 10.1155/2016/7951285 |
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Host and parasite factors are involved in the establishment and development of CL. Host factors include immune response and genetic background. NRAMP1 (Natural Resistance Associated Macrophage Protein 1) is important in innate immunity. Polymorphisms in NRAMP1 have been associated with susceptibility or resistance to infectious and autoimmune diseases. To study the association of NRAMP1 mutations with CL in patients from Calakmul, Campeche, samples from 115 CL patients and 69 samples of healthy people from the same area were evaluated. Five regions in NRAMP1 were amplified and digested, looking for mutations in the promoter region (−524G/C), exon 3 (274C/T), exon 8 (823 C7T), and exon 15 (G/A) and deletion of 4 bp in the 3′UTR region. We found a statistical association between polymorphisms in 3′UTR region and exon 8 and CL [χ2=13.26; p<0.05; OR = 17.00; IC of 95% (2.24–128.99)]. Some patients who needed more than 40 doses of Glucantime® to heal injuries presented mutations in exons 3, 8, and 15. Multiple or ear lesions were not associated with NRAMP1 polymorphism.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2016/7951285</identifier><identifier>PMID: 27830154</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomedical research ; Cation Transport Proteins - genetics ; Child ; Deoxyribonucleic acid ; DNA ; Drug dosages ; Female ; Genetic aspects ; Genetic Markers - genetics ; Genetic Predisposition to Disease - epidemiology ; Genetic Predisposition to Disease - genetics ; Humans ; Immune response ; Infections ; Leishmaniasis, Cutaneous ; Leishmaniasis, Cutaneous - diagnosis ; Leishmaniasis, Cutaneous - epidemiology ; Leishmaniasis, Cutaneous - genetics ; Male ; Medical research ; Medicine, Experimental ; Mexico - epidemiology ; Microorganisms ; Middle Aged ; Mutation ; Parasitic diseases ; Patients ; Polymorphism, Single Nucleotide - genetics ; Prevalence ; Proteins ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity ; Tropical diseases</subject><ispartof>BioMed research international, 2016-01, Vol.2016 (2016), p.1-8</ispartof><rights>Copyright © 2016 Mirsha Pamela Hernández-Rivera et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Mirsha Pamela Hernández-Rivera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Mirsha Pamela Hernández-Rivera et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-3f2e84f34cff777d338df051f817b13cf137df2bbd0fddff7e838b2604636c8f3</citedby><cites>FETCH-LOGICAL-c532t-3f2e84f34cff777d338df051f817b13cf137df2bbd0fddff7e838b2604636c8f3</cites><orcidid>0000-0001-9942-2737 ; 0000-0001-7455-0070</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088330/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088330/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27830154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Spencer, Charles</contributor><creatorcontrib>Cancino-Díaz, Mario E.</creatorcontrib><creatorcontrib>Monroy-Ostria, Amalia</creatorcontrib><creatorcontrib>Chiñas-Pérez, Adelaido</creatorcontrib><creatorcontrib>Ramírez-Ramírez, Alicia</creatorcontrib><creatorcontrib>Hernández-Rivera, Mirsha Pamela</creatorcontrib><creatorcontrib>Hernández-Montes, Omar</creatorcontrib><title>NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Cutaneous leishmaniasis (CL) is endemic in Campeche state, Mexico. Host and parasite factors are involved in the establishment and development of CL. Host factors include immune response and genetic background. NRAMP1 (Natural Resistance Associated Macrophage Protein 1) is important in innate immunity. Polymorphisms in NRAMP1 have been associated with susceptibility or resistance to infectious and autoimmune diseases. To study the association of NRAMP1 mutations with CL in patients from Calakmul, Campeche, samples from 115 CL patients and 69 samples of healthy people from the same area were evaluated. Five regions in NRAMP1 were amplified and digested, looking for mutations in the promoter region (−524G/C), exon 3 (274C/T), exon 8 (823 C7T), and exon 15 (G/A) and deletion of 4 bp in the 3′UTR region. We found a statistical association between polymorphisms in 3′UTR region and exon 8 and CL [χ2=13.26; p<0.05; OR = 17.00; IC of 95% (2.24–128.99)]. Some patients who needed more than 40 doses of Glucantime® to heal injuries presented mutations in exons 3, 8, and 15. Multiple or ear lesions were not associated with NRAMP1 polymorphism.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical research</subject><subject>Cation Transport Proteins - genetics</subject><subject>Child</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic Markers - genetics</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Humans</subject><subject>Immune response</subject><subject>Infections</subject><subject>Leishmaniasis, Cutaneous</subject><subject>Leishmaniasis, Cutaneous - diagnosis</subject><subject>Leishmaniasis, Cutaneous - epidemiology</subject><subject>Leishmaniasis, Cutaneous - genetics</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mexico - epidemiology</subject><subject>Microorganisms</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Parasitic diseases</subject><subject>Patients</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Reproducibility of Results</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Tropical diseases</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks9v0zAUxyPExKZtN84oEhckKPPzi2PnglRVjE1qYeLHiYPlOPbqLYk7OwH63-PSUhVO88W2_NH3ve_zN8ueA3kLwNgFJVBe8IoBFexJdkIRikkJBTzdnxGPs_MY70haAkpSlc-yY8oFEmDFSfb94-fp4gbyG9-uOx9WSxe7mLfu3uRfxqjNanC1a92wzhcq3JuQuz5fmF9Oqz6_9HqMubf5bBxUb3y6zI2Ly071TkUXz7Ijq9poznf7afbt8v3X2dVk_unD9Ww6n2iGdJigpUYUFgttLee8QRSNJQysAF4DagvIG0vruiG2aRJjBIqalqQosdTC4mn2bqu7GuvONNr0Q1CtXAXXqbCWXjn570vvlvLW_5CMCIFIksCrnUDwD6OJg-xc8t62W1cSRFEWhGNVPALFCoioSp7Ql_-hd34MfZrEH8FUmx5St6o10vXWpxb1RlROGSUcGKebsm-2lA4-xmDs3h0QuUmC3CRB7pKQ8BeHE9nDf_89Aa-3wNL1jfrpHilnEmOsOqArISrE33EYw9c</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Cancino-Díaz, Mario E.</creator><creator>Monroy-Ostria, Amalia</creator><creator>Chiñas-Pérez, Adelaido</creator><creator>Ramírez-Ramírez, Alicia</creator><creator>Hernández-Rivera, Mirsha Pamela</creator><creator>Hernández-Montes, Omar</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9942-2737</orcidid><orcidid>https://orcid.org/0000-0001-7455-0070</orcidid></search><sort><creationdate>20160101</creationdate><title>NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis</title><author>Cancino-Díaz, Mario E. ; Monroy-Ostria, Amalia ; Chiñas-Pérez, Adelaido ; Ramírez-Ramírez, Alicia ; Hernández-Rivera, Mirsha Pamela ; Hernández-Montes, Omar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-3f2e84f34cff777d338df051f817b13cf137df2bbd0fddff7e838b2604636c8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical research</topic><topic>Cation Transport Proteins - genetics</topic><topic>Child</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genetic Markers - genetics</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Humans</topic><topic>Immune response</topic><topic>Infections</topic><topic>Leishmaniasis, Cutaneous</topic><topic>Leishmaniasis, Cutaneous - diagnosis</topic><topic>Leishmaniasis, Cutaneous - epidemiology</topic><topic>Leishmaniasis, Cutaneous - genetics</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mexico - epidemiology</topic><topic>Microorganisms</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Parasitic diseases</topic><topic>Patients</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Prevalence</topic><topic>Proteins</topic><topic>Reproducibility of Results</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Tropical diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cancino-Díaz, Mario E.</creatorcontrib><creatorcontrib>Monroy-Ostria, Amalia</creatorcontrib><creatorcontrib>Chiñas-Pérez, Adelaido</creatorcontrib><creatorcontrib>Ramírez-Ramírez, Alicia</creatorcontrib><creatorcontrib>Hernández-Rivera, Mirsha Pamela</creatorcontrib><creatorcontrib>Hernández-Montes, Omar</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cancino-Díaz, Mario E.</au><au>Monroy-Ostria, Amalia</au><au>Chiñas-Pérez, Adelaido</au><au>Ramírez-Ramírez, Alicia</au><au>Hernández-Rivera, Mirsha Pamela</au><au>Hernández-Montes, Omar</au><au>Spencer, Charles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Cutaneous leishmaniasis (CL) is endemic in Campeche state, Mexico. Host and parasite factors are involved in the establishment and development of CL. Host factors include immune response and genetic background. NRAMP1 (Natural Resistance Associated Macrophage Protein 1) is important in innate immunity. Polymorphisms in NRAMP1 have been associated with susceptibility or resistance to infectious and autoimmune diseases. To study the association of NRAMP1 mutations with CL in patients from Calakmul, Campeche, samples from 115 CL patients and 69 samples of healthy people from the same area were evaluated. Five regions in NRAMP1 were amplified and digested, looking for mutations in the promoter region (−524G/C), exon 3 (274C/T), exon 8 (823 C7T), and exon 15 (G/A) and deletion of 4 bp in the 3′UTR region. We found a statistical association between polymorphisms in 3′UTR region and exon 8 and CL [χ2=13.26; p<0.05; OR = 17.00; IC of 95% (2.24–128.99)]. Some patients who needed more than 40 doses of Glucantime® to heal injuries presented mutations in exons 3, 8, and 15. Multiple or ear lesions were not associated with NRAMP1 polymorphism.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>27830154</pmid><doi>10.1155/2016/7951285</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9942-2737</orcidid><orcidid>https://orcid.org/0000-0001-7455-0070</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biomedical research Cation Transport Proteins - genetics Child Deoxyribonucleic acid DNA Drug dosages Female Genetic aspects Genetic Markers - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Humans Immune response Infections Leishmaniasis, Cutaneous Leishmaniasis, Cutaneous - diagnosis Leishmaniasis, Cutaneous - epidemiology Leishmaniasis, Cutaneous - genetics Male Medical research Medicine, Experimental Mexico - epidemiology Microorganisms Middle Aged Mutation Parasitic diseases Patients Polymorphism, Single Nucleotide - genetics Prevalence Proteins Reproducibility of Results Risk Factors Sensitivity and Specificity Tropical diseases |
| title | NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis |
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