Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease

Reduced smooth muscle (SM)‐specific α2 Na+ pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst SM‐α2 overexpression lowers basal BP and decreases Ang II/salt sensitivity. Prolonged ouabain infusion induces hypertension i...

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Veröffentlicht in:	The Journal of physiology 2016-11, Vol.594 (21), p.6079-6103
Hauptverfasser:	Blaustein, Mordecai P., Chen, Ling, Hamlyn, John M., Leenen, Frans H. H., Lingrel, Jerry B., Wier, W. Gil, Zhang, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensins - metabolism Animals artery Binding Sites cardiac hypertrophy Cardiotonic Agents - pharmacology Cardiovascular Conditions, Disorders and Treatments Cardiovascular Physiology Cardiovascular System - drug effects Cardiovascular System - metabolism heart failure Humans hypertension Hypertension - metabolism Hypertension - physiopathology Ouabain - pharmacology Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - chemistry Sodium-Potassium-Exchanging ATPase - metabolism Sympathetic Nervous System - metabolism Sympathetic Nervous System - physiology Topical Review
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