Na-K-2Cl cotransporter gene expression and function during enterocyte differentiation. Modulation of Cl- secretory capacity by butyrate

The basolateral Na-K-2Cl cotransporter (NKCC1) is a key component of the intestinal crypt cell secretory apparatus. Its fate during the transition to absorptive enterocyte and the potential impact of its altered expression on secretory output have not been addressed. In this report, NKCC1 mRNA was f...

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Veröffentlicht in:	The Journal of clinical investigation 1998-05, Vol.101 (10), p.2072-2079
Hauptverfasser:	Matthews, J B, Hassan, I, Meng, S, Archer, S Y, Hrnjez, B J, Hodin, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bumetanide - pharmacology Butyrates - pharmacology Butyric Acid Carrier Proteins - genetics Cell Differentiation - physiology Cell Line Chlorides - pharmacokinetics Colforsin - pharmacology Cyclic AMP - pharmacology Cystic Fibrosis Transmembrane Conductance Regulator - genetics Diarrhea - physiopathology Diarrhea - therapy Down-Regulation - drug effects Gene Expression Regulation, Developmental - genetics Humans Intestines - physiology Male Microvilli - physiology Potassium - pharmacokinetics Protein Synthesis Inhibitors - pharmacology Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Sodium-Potassium-Chloride Symporters
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