Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle

Control of myocardial energetics by Ca2+ signal propagation to the mitochondrial matrix includes local Ca2+ delivery from sarcoplasmic reticulum (SR) ryanodine receptors (RyR2) to the inner mitochondrial membrane (IMM) Ca2+ uniporter (mtCU). mtCU activity in cardiac mitochondria is relatively low, w...

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Veröffentlicht in:	The Journal of biological chemistry 2016-10, Vol.291 (44), p.23343-23362
Hauptverfasser:	De La Fuente, Sergio, Fernandez-Sanz, Celia, Vail, Caitlin, Agra, Elorm J., Holmstrom, Kira, Sun, Junhui, Mishra, Jyotsna, Williams, Dewight, Finkel, Toren, Murphy, Elizabeth, Joseph, Suresh K., Sheu, Shey-Shing, Csordás, György
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism calcium channel Calcium Channels - genetics Calcium Channels - metabolism Calcium Signaling calcium transport Cell Biology Male Mice Mice, Inbred C57BL microscopic imaging Mitochondria, Heart - metabolism Mitochondrial Membranes - metabolism mitochondrial transport Myocardium - metabolism Myocytes, Cardiac - metabolism Rats Rats, Sprague-Dawley Sarcoplasmic Reticulum - genetics Sarcoplasmic Reticulum - metabolism signaling
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