Hydrogen Bonding of 1,2-Azaborines in the Binding Cavity of T4 Lysozyme Mutants: Structures and Thermodynamics

Protein crystallography and calorimetry were used to characterize the binding of 1,2-azaborines to model cavities in T4 lysozyme in direct comparison to their carbonaceous counterparts. In the apolar L99A cavity, affinity for Ab dropped only slightly versus benzene. In the cavity designed to accommo...

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Veröffentlicht in:	Journal of the American Chemical Society 2016-09, Vol.138 (37), p.12021-12024
Hauptverfasser:	Lee, Hyelee, Fischer, Marcus, Shoichet, Brian K, Liu, Shih-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Boron Compounds - chemistry Calorimetry Hydrogen Bonding Models, Molecular Molecular Structure Muramidase - chemistry Muramidase - metabolism Thermodynamics
Online-Zugang:	Volltext
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