A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma

Despite advances in clinical management, 5-year survival rate in patients with late-stage head and neck squamous cell carcinoma (HNSCC) has not improved significantly over the past decade. Targeted therapies have emerged as one of the most promising approaches to treat several malignancies. Though t...

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Veröffentlicht in:	Scientific reports 2016-10, Vol.6 (1), p.36132, Article 36132
Hauptverfasser:	Radhakrishnan, Aneesha, Nanjappa, Vishalakshi, Raja, Remya, Sathe, Gajanan, Puttamallesh, Vinuth N., Jain, Ankit P., Pinto, Sneha M., Balaji, Sai A., Chavan, Sandip, Sahasrabuddhe, Nandini A., Mathur, Premendu P., Kumar, Mahesh M., Prasad, T. S. Keshava, Santosh, Vani, Sukumar, Geethanjali, Califano, Joseph A., Rangarajan, Annapoorni, Sidransky, David, Pandey, Akhilesh, Gowda, Harsha, Chatterjee, Aditi
Format:	Artikel
Sprache:	eng
Schlagworte:	13 45 631/67/1665 692/53 82 96 Animals Apoptosis Apoptosis - drug effects bcl-X Protein - metabolism Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Caspase 9 - metabolism Cell Line Cell Movement - drug effects Dyrk Kinases Female Forkhead Box Protein O3 - metabolism Harmine - therapeutic use Harmine - toxicity Head & neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humanities and Social Sciences Humans Immunohistochemistry Mice Mice, Nude multidisciplinary Phosphorylation Phosphorylation - drug effects Phosphotyrosine Phosphotyrosine - analysis Phosphotyrosine - metabolism Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein-tyrosine kinase Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA Interference RNA, Small Interfering - metabolism Rodents Science Signal transduction Small Molecule Libraries - metabolism Small Molecule Libraries - therapeutic use Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Survival Tandem Mass Spectrometry Tissue Array Analysis Transplantation, Heterologous Tumors Xenografts
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