Compact and Thermosensitive Nature-inspired Micropump
Liquid transportation without employing a bulky power source, often observed in nature, has been an essential prerequisite for smart applications of microfluidic devices. In this report, a leaf-inspired micropump (LIM) which is composed of thermo-responsive stomata-inspired membrane (SIM) and mesoph...
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| Veröffentlicht in: | Scientific reports 2016-10, Vol.6 (1), p.36085-36085, Article 36085 |
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| creator | Kim, Hyejeong Kim, Kiwoong Lee, Sang Joon |
| description | Liquid transportation without employing a bulky power source, often observed in nature, has been an essential prerequisite for smart applications of microfluidic devices. In this report, a leaf-inspired micropump (LIM) which is composed of thermo-responsive stomata-inspired membrane (SIM) and mesophyll-inspired agarose cryogel (MAC) is proposed. The LIM provides a durable flow rate of 30 μl/h ·
cm
2
for more than 30 h at room temperature without external mechanical power source. By adapting a thermo-responsive polymer, the LIM can smartly adjust the delivery rate of a therapeutic liquid in response to temperature changes. In addition, as the LIM is compact, portable, and easily integrated into any liquid, it might be utilized as an essential component in advanced hand-held drug delivery devices. |
| doi_str_mv | 10.1038/srep36085 |
| format | Article |
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cm
2
for more than 30 h at room temperature without external mechanical power source. By adapting a thermo-responsive polymer, the LIM can smartly adjust the delivery rate of a therapeutic liquid in response to temperature changes. In addition, as the LIM is compact, portable, and easily integrated into any liquid, it might be utilized as an essential component in advanced hand-held drug delivery devices.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep36085</identifier><identifier>PMID: 27796357</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/166/988 ; 692/700/155 ; Drug delivery ; Drug delivery systems ; Drug dosages ; Flow rates ; Humanities and Social Sciences ; Hydraulics ; Hydrogels ; Mesophyll ; Microfluidics ; multidisciplinary ; Ostomy ; Permeability ; Polymers ; Power ; Science ; Stomata ; Temperature effects</subject><ispartof>Scientific reports, 2016-10, Vol.6 (1), p.36085-36085, Article 36085</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Oct 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-83c14efea10ed42e6754bb3985b2424748f408ac4c1e56aae1bd25734f2bacd73</citedby><cites>FETCH-LOGICAL-c574t-83c14efea10ed42e6754bb3985b2424748f408ac4c1e56aae1bd25734f2bacd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086846/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086846/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,41125,42194,51581,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27796357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hyejeong</creatorcontrib><creatorcontrib>Kim, Kiwoong</creatorcontrib><creatorcontrib>Lee, Sang Joon</creatorcontrib><title>Compact and Thermosensitive Nature-inspired Micropump</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Liquid transportation without employing a bulky power source, often observed in nature, has been an essential prerequisite for smart applications of microfluidic devices. In this report, a leaf-inspired micropump (LIM) which is composed of thermo-responsive stomata-inspired membrane (SIM) and mesophyll-inspired agarose cryogel (MAC) is proposed. The LIM provides a durable flow rate of 30 μl/h ·
cm
2
for more than 30 h at room temperature without external mechanical power source. By adapting a thermo-responsive polymer, the LIM can smartly adjust the delivery rate of a therapeutic liquid in response to temperature changes. 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In this report, a leaf-inspired micropump (LIM) which is composed of thermo-responsive stomata-inspired membrane (SIM) and mesophyll-inspired agarose cryogel (MAC) is proposed. The LIM provides a durable flow rate of 30 μl/h ·
cm
2
for more than 30 h at room temperature without external mechanical power source. By adapting a thermo-responsive polymer, the LIM can smartly adjust the delivery rate of a therapeutic liquid in response to temperature changes. In addition, as the LIM is compact, portable, and easily integrated into any liquid, it might be utilized as an essential component in advanced hand-held drug delivery devices.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27796357</pmid><doi>10.1038/srep36085</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 639/166/988 692/700/155 Drug delivery Drug delivery systems Drug dosages Flow rates Humanities and Social Sciences Hydraulics Hydrogels Mesophyll Microfluidics multidisciplinary Ostomy Permeability Polymers Power Science Stomata Temperature effects |
| title | Compact and Thermosensitive Nature-inspired Micropump |
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