Effects of Short-Term Exposure to Particulate Air Pollutants on the Inflammatory Response and Respiratory Symptoms: A Panel Study in Schoolchildren from Rural Areas of Japan
The relationship between particulate air pollutants and respiratory symptoms in children has not been consistent among studies, potentially owing to differences in the inflammatory response to different particulate air pollutants. This study aimed to investigate the effect of particulate air polluta...
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| Veröffentlicht in: | International journal of environmental research and public health 2016-09, Vol.13 (10), p.983 |
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| container_title | International journal of environmental research and public health |
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| creator | Watanabe, Masanari Noma, Hisashi Kurai, Jun Sano, Hiroyuki Hantan, Degejirihu Ueki, Masaru Kitano, Hiroya Shimizu, Eiji |
| description | The relationship between particulate air pollutants and respiratory symptoms in children has not been consistent among studies, potentially owing to differences in the inflammatory response to different particulate air pollutants. This study aimed to investigate the effect of particulate air pollutants on respiratory symptoms and the inflammatory response in schoolchildren. Three hundred-and-sixty children were included in the study. The children recorded daily respiratory symptom scores for October 2015. In addition, the daily amount of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α production was assessed in THP1 cells stimulated with suspended particulate matter (SPM), which was collected every day during the study period. Generalized estimating equation logistic regression analyses were used to estimate the associations among respiratory symptoms and the daily levels of SPM, IL-6, IL-8, and TNF-α. Daily SPM levels were not associated with respiratory symptoms or the daily IL-6, IL-8, and TNF-α levels. Conversely, there was a significant association between respiratory symptoms and the daily IL-6, IL-8, and TNF-α levels. These results suggested that the effects of particulate air pollutants on respiratory symptoms in schoolchildren might depend more on the pro-inflammatory response to them than on their mass concentration. |
| doi_str_mv | 10.3390/ijerph13100983 |
| format | Article |
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This study aimed to investigate the effect of particulate air pollutants on respiratory symptoms and the inflammatory response in schoolchildren. Three hundred-and-sixty children were included in the study. The children recorded daily respiratory symptom scores for October 2015. In addition, the daily amount of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α production was assessed in THP1 cells stimulated with suspended particulate matter (SPM), which was collected every day during the study period. Generalized estimating equation logistic regression analyses were used to estimate the associations among respiratory symptoms and the daily levels of SPM, IL-6, IL-8, and TNF-α. Daily SPM levels were not associated with respiratory symptoms or the daily IL-6, IL-8, and TNF-α levels. Conversely, there was a significant association between respiratory symptoms and the daily IL-6, IL-8, and TNF-α levels. These results suggested that the effects of particulate air pollutants on respiratory symptoms in schoolchildren might depend more on the pro-inflammatory response to them than on their mass concentration.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph13100983</identifier><identifier>PMID: 27706066</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Adolescent ; Air Pollutants - toxicity ; Child ; Female ; Humans ; Inflammation - chemically induced ; Inflammation - metabolism ; Interleukin-6 - genetics ; Interleukin-6 - metabolism ; Interleukin-8 - genetics ; Interleukin-8 - metabolism ; Japan ; Male ; Particulate Matter - toxicity ; Respiratory Tract Diseases - chemically induced ; Respiratory Tract Diseases - metabolism ; Time Factors ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>International journal of environmental research and public health, 2016-09, Vol.13 (10), p.983</ispartof><rights>2016 by the authors; licensee MDPI, Basel, Switzerland. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-f27c62bb651dd179b547cbbf25e1dd15755b8434ba49668b299dd029f9d9416b3</citedby><cites>FETCH-LOGICAL-c456t-f27c62bb651dd179b547cbbf25e1dd15755b8434ba49668b299dd029f9d9416b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086722/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086722/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27706066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, Masanari</creatorcontrib><creatorcontrib>Noma, Hisashi</creatorcontrib><creatorcontrib>Kurai, Jun</creatorcontrib><creatorcontrib>Sano, Hiroyuki</creatorcontrib><creatorcontrib>Hantan, Degejirihu</creatorcontrib><creatorcontrib>Ueki, Masaru</creatorcontrib><creatorcontrib>Kitano, Hiroya</creatorcontrib><creatorcontrib>Shimizu, Eiji</creatorcontrib><title>Effects of Short-Term Exposure to Particulate Air Pollutants on the Inflammatory Response and Respiratory Symptoms: A Panel Study in Schoolchildren from Rural Areas of Japan</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>The relationship between particulate air pollutants and respiratory symptoms in children has not been consistent among studies, potentially owing to differences in the inflammatory response to different particulate air pollutants. This study aimed to investigate the effect of particulate air pollutants on respiratory symptoms and the inflammatory response in schoolchildren. Three hundred-and-sixty children were included in the study. The children recorded daily respiratory symptom scores for October 2015. In addition, the daily amount of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α production was assessed in THP1 cells stimulated with suspended particulate matter (SPM), which was collected every day during the study period. Generalized estimating equation logistic regression analyses were used to estimate the associations among respiratory symptoms and the daily levels of SPM, IL-6, IL-8, and TNF-α. Daily SPM levels were not associated with respiratory symptoms or the daily IL-6, IL-8, and TNF-α levels. Conversely, there was a significant association between respiratory symptoms and the daily IL-6, IL-8, and TNF-α levels. These results suggested that the effects of particulate air pollutants on respiratory symptoms in schoolchildren might depend more on the pro-inflammatory response to them than on their mass concentration.</description><subject>Adolescent</subject><subject>Air Pollutants - toxicity</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - metabolism</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - metabolism</subject><subject>Interleukin-8 - genetics</subject><subject>Interleukin-8 - metabolism</subject><subject>Japan</subject><subject>Male</subject><subject>Particulate Matter - toxicity</subject><subject>Respiratory Tract Diseases - chemically induced</subject><subject>Respiratory Tract Diseases - metabolism</subject><subject>Time Factors</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1P3DAUtKpWhUKvPVY-9hJqx7Ed91BphRZKhQRi6TmyHbsxcuzUdqruj-I_kmUpgtP7mjdvngaATxidECLQV3dn0jRgghESLXkDDjFjqGoYwm9f5AfgQ853CJG2YeI9OKg5Rwwxdgju19YaXTKMFm6GmEp1a9II1_-mmOdkYInwWqbi9OxlMXDlEryO3s9Fht1SgGUw8CJYL8dRlpi28MbkKYZsoAz9Y-HSfrDZjlOJY_4GVwtnMB5uytxvoQtwo4cYvR6c75MJ0KY4wps5SQ9XychHcT_lJMMxeGelz-bjUzwCv87Wt6c_qsur84vT1WWlG8pKZWuuWa0Uo7jvMReKNlwrZWtqdg3KKVVtQxolG8FYq2oh-h7VwopeNJgpcgS-73mnWY2m1yaURUw3JTfKtO2idN3rSXBD9zv-7ShqGa_rheDLE0GKf2aTSze6rI33y99xzh1uCSUcI44W6MkeqlPMORn7fAajbudx99rjZeHzS3HP8P-mkge1nqfI</recordid><startdate>20160930</startdate><enddate>20160930</enddate><creator>Watanabe, Masanari</creator><creator>Noma, Hisashi</creator><creator>Kurai, Jun</creator><creator>Sano, Hiroyuki</creator><creator>Hantan, Degejirihu</creator><creator>Ueki, Masaru</creator><creator>Kitano, Hiroya</creator><creator>Shimizu, Eiji</creator><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160930</creationdate><title>Effects of Short-Term Exposure to Particulate Air Pollutants on the Inflammatory Response and Respiratory Symptoms: A Panel Study in Schoolchildren from Rural Areas of Japan</title><author>Watanabe, Masanari ; 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This study aimed to investigate the effect of particulate air pollutants on respiratory symptoms and the inflammatory response in schoolchildren. Three hundred-and-sixty children were included in the study. The children recorded daily respiratory symptom scores for October 2015. In addition, the daily amount of interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α production was assessed in THP1 cells stimulated with suspended particulate matter (SPM), which was collected every day during the study period. Generalized estimating equation logistic regression analyses were used to estimate the associations among respiratory symptoms and the daily levels of SPM, IL-6, IL-8, and TNF-α. Daily SPM levels were not associated with respiratory symptoms or the daily IL-6, IL-8, and TNF-α levels. Conversely, there was a significant association between respiratory symptoms and the daily IL-6, IL-8, and TNF-α levels. 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| subjects | Adolescent Air Pollutants - toxicity Child Female Humans Inflammation - chemically induced Inflammation - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Interleukin-8 - genetics Interleukin-8 - metabolism Japan Male Particulate Matter - toxicity Respiratory Tract Diseases - chemically induced Respiratory Tract Diseases - metabolism Time Factors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism |
| title | Effects of Short-Term Exposure to Particulate Air Pollutants on the Inflammatory Response and Respiratory Symptoms: A Panel Study in Schoolchildren from Rural Areas of Japan |
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