Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease
Aims. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD). Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP, n=33), patients with acute coro...
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| creator | Huang, Bian Ge, Xuan Chang, Hao-Teng Lu, Ting-Ting Peng, Ji-Ren Li, Weimin |
| description | Aims. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD). Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP, n=33), patients with acute coronary syndrome (ACS, n=49), and controls (n=42). Protein quantification was done using ELISA. Results. The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis. Conclusions. Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD. |
| doi_str_mv | 10.1155/2016/3708905 |
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To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD). Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP, n=33), patients with acute coronary syndrome (ACS, n=49), and controls (n=42). Protein quantification was done using ELISA. Results. The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis. Conclusions. Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2016/3708905</identifier><identifier>PMID: 27830142</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acute coronary syndromes ; Adult ; Aged ; Aged, 80 and over ; Angina pectoris ; Atherosclerosis ; Biomarkers ; Biomarkers - blood ; Cardiac patients ; Cardiology ; Cardiovascular disease ; Care and treatment ; Cohort Studies ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - enzymology ; Coronary Artery Disease - epidemiology ; Coronary vessels ; Diabetes ; Enzymes ; Female ; Hospitals ; Humans ; Hypertension ; Male ; Medical imaging ; Middle Aged ; Mortality ; Oxidative stress ; Plasma ; Risk factors ; ROC Curve ; Science education ; Superoxide ; Superoxide Dismutase - blood</subject><ispartof>BioMed research international, 2016-01, Vol.2016 (2016), p.1-9</ispartof><rights>Copyright © 2016 Ji-Ren Peng et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Ji-Ren Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Ji-Ren Peng et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-4ec67939ca2983fdcc5e214ca219eda6944f45d89c60e3bdb0f900679a0e4ab93</citedby><cites>FETCH-LOGICAL-c532t-4ec67939ca2983fdcc5e214ca219eda6944f45d89c60e3bdb0f900679a0e4ab93</cites><orcidid>0000-0001-7158-7222 ; 0000-0002-9065-4432</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086506/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086506/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27830142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>de Franciscis, Stefano</contributor><creatorcontrib>Huang, Bian</creatorcontrib><creatorcontrib>Ge, Xuan</creatorcontrib><creatorcontrib>Chang, Hao-Teng</creatorcontrib><creatorcontrib>Lu, Ting-Ting</creatorcontrib><creatorcontrib>Peng, Ji-Ren</creatorcontrib><creatorcontrib>Li, Weimin</creatorcontrib><title>Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Aims. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD). Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP, n=33), patients with acute coronary syndrome (ACS, n=49), and controls (n=42). Protein quantification was done using ELISA. Results. The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis. Conclusions. Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD.</description><subject>Acute coronary syndromes</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angina pectoris</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cardiac patients</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Cohort Studies</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - enzymology</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Enzymes</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Oxidative stress</subject><subject>Plasma</subject><subject>Risk factors</subject><subject>ROC Curve</subject><subject>Science education</subject><subject>Superoxide</subject><subject>Superoxide Dismutase - blood</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNks1vEzEQxVcIRKvSG2dkiQsShPp77QtSFMqHFIlKwNk43tnG1e462Lsp_PdMSAiFU30ZW_7N0_P4VdVTRl8zptQFp0xfiJoaS9WD6pQLJmeaSfbwuBfipDov5YbiMkxTqx9XJ7w2gjLJT6tvlx1s_QgNWcIWukJSS646X3pPPk8byOlHbIC8jaWfRl-gEEb80BBO4kCu_BhhGAu5jeOaLFJOg88_yTyPgAV7ADueVI9a3xU4P9Sz6uu7yy-LD7Plp_cfF_PlLCjBx5mEoGsrbPDcGtE2ISjgTOKRWWi8tlK2UjXGBk1BrJoVbS2l2OIpSL-y4qx6s9fdTKsemoDGsu_cJsceTbnko_v3Zohrd522TlGjFdUo8OIgkNP3Ccro-lgCdJ0fIE3FMSO1sFyL-h6osIwaUzNEn_-H3qQpDziJ34IIMVP_pa59By4ObUKLYSfq5orTmknkkHq1p0JOpWRoj69j1O3i4HZxcIc4IP7s7kSO8J_PR-DlHljHofG38Z5ygAy0_g5ta4k5-wXGsMSA</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Huang, Bian</creator><creator>Ge, Xuan</creator><creator>Chang, Hao-Teng</creator><creator>Lu, Ting-Ting</creator><creator>Peng, Ji-Ren</creator><creator>Li, Weimin</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7158-7222</orcidid><orcidid>https://orcid.org/0000-0002-9065-4432</orcidid></search><sort><creationdate>20160101</creationdate><title>Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease</title><author>Huang, Bian ; Ge, Xuan ; Chang, Hao-Teng ; Lu, Ting-Ting ; Peng, Ji-Ren ; Li, Weimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-4ec67939ca2983fdcc5e214ca219eda6944f45d89c60e3bdb0f900679a0e4ab93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute coronary syndromes</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angina pectoris</topic><topic>Atherosclerosis</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Cardiac patients</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Cohort Studies</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - enzymology</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Enzymes</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Oxidative stress</topic><topic>Plasma</topic><topic>Risk factors</topic><topic>ROC Curve</topic><topic>Science education</topic><topic>Superoxide</topic><topic>Superoxide Dismutase - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Bian</creatorcontrib><creatorcontrib>Ge, Xuan</creatorcontrib><creatorcontrib>Chang, Hao-Teng</creatorcontrib><creatorcontrib>Lu, Ting-Ting</creatorcontrib><creatorcontrib>Peng, Ji-Ren</creatorcontrib><creatorcontrib>Li, Weimin</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Bian</au><au>Ge, Xuan</au><au>Chang, Hao-Teng</au><au>Lu, Ting-Ting</au><au>Peng, Ji-Ren</au><au>Li, Weimin</au><au>de Franciscis, Stefano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Aims. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD). Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP, n=33), patients with acute coronary syndrome (ACS, n=49), and controls (n=42). Protein quantification was done using ELISA. Results. The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis. Conclusions. Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>27830142</pmid><doi>10.1155/2016/3708905</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7158-7222</orcidid><orcidid>https://orcid.org/0000-0002-9065-4432</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute coronary syndromes Adult Aged Aged, 80 and over Angina pectoris Atherosclerosis Biomarkers Biomarkers - blood Cardiac patients Cardiology Cardiovascular disease Care and treatment Cohort Studies Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - enzymology Coronary Artery Disease - epidemiology Coronary vessels Diabetes Enzymes Female Hospitals Humans Hypertension Male Medical imaging Middle Aged Mortality Oxidative stress Plasma Risk factors ROC Curve Science education Superoxide Superoxide Dismutase - blood |
| title | Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease |
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